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Fouad H, AlFotawi R, Alothman OY, et al. Porous Polyethylene Coated with Functionalized Hydroxyapatite Particles as a Bone Reconstruction Material. Materials (Basel). 2018;11(4)doi: 10.3390/ma11040521.
Fouad, H., AlFotawi, R., Alothman, O. Y., Alshammari, B. A., Alfayez, M., Hashem, M., & Mahmood, A. (2018). Porous Polyethylene Coated with Functionalized Hydroxyapatite Particles as a Bone Reconstruction Material. Materials (Basel, Switzerland), 11(4), . https://doi.org/10.3390/ma11040521
Fouad, H, et al. "Porous Polyethylene Coated with Functionalized Hydroxyapatite Particles as a Bone Reconstruction Material." Materials (Basel, Switzerland) vol. 11,4 (2018). doi: https://doi.org/10.3390/ma11040521
Fouad H, AlFotawi R, Alothman OY, Alshammari BA, Alfayez M, Hashem M, Mahmood A. Porous Polyethylene Coated with Functionalized Hydroxyapatite Particles as a Bone Reconstruction Material. Materials (Basel). 2018 Mar 29;11(4). doi: 10.3390/ma11040521. PMID: 29596358; PMCID: PMC5951367.
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Materials (Basel). 2018 Mar 29;11(4). doi: 10.3390/ma11040521.

Porous Polyethylene Coated with Functionalized Hydroxyapatite Particles as a Bone Reconstruction Material.

Materials (Basel, Switzerland)

H Fouad, Randa AlFotawi, Othman Y Alothman, Basheer A Alshammari, Musaad Alfayez, Mohamed Hashem, Amer Mahmood

Affiliations

  1. Applied Medical Science Department, Community College, King Saud University, Riyadh 11437, Saudi Arabia. [email protected].
  2. Department of Biomedical Engineering, Faculty of Engineering, Helwan University, Helwan 11792, Egypt. [email protected].
  3. Maxillofacial Surgery Department, Dental Faculty, King Saud University, Riyadh 11545, Saudi Arabia. [email protected].
  4. Chemical Engineering Department, King Saud University, Riyadh 11421, Saudi Arabia. [email protected].
  5. Deanship of Graduate Studies, Saudi Electronic University, Riyadh 11637, Saudi Arabia. [email protected].
  6. Material Science Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi Arabia. [email protected].
  7. Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia. [email protected].
  8. Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh 11437, Saudi Arabia. [email protected].
  9. Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia. [email protected].

PMID: 29596358 PMCID: PMC5951367 DOI: 10.3390/ma11040521

Abstract

In this study, porous polyethylene scaffolds were examined as bone substitutes in vitro and in vivo in critical-sized calvarial bone defects in transgenic Sprague-Dawley rats. A microscopic examination revealed that the pores appeared to be interconnected across the material, making them suitable for cell growth. The creep recovery behavior of porous polyethylene at different loads indicated that the creep strain had two main portions. In both portions, strain increased with increased applied load and temperature. In terms of the thermographic behavior of the material, remarkable changes in melting temperature and heat fusion were revealed with increased the heating rates. The tensile strength results showed that the material was sensitive to the strain rate and that there was adequate mechanical strength to support cell growth. The in vitro cell culture results showed that human bone marrow mesenchymal stem cells attached to the porous polyethylene scaffold. Calcium sulfate-hydroxyapatite (CS-HA) coating of the scaffold not only improved attachment but also increased the proliferation of human bone marrow mesenchymal stem cells. In vivo, histological analysis showed that the study groups had active bone remodeling at the border of the defect. Bone regeneration at the border was also evident, which confirmed that the polyethylene acted as an osteoconductive bone graft. Furthermore, bone formation inside the pores of the coated polyethylene was also noted, which would enhance the process of osteointegration.

Keywords: hydroxyapatite; mesenchymal stem cells; porous polyethylene

Conflict of interest statement

The authors declare that there are no conflicts of interest or state among all the contributors.

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