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Namlı Kalem M, Kalem Z, Bakırarar B, et al. The effect of progesterone use in the first trimester on fetal nuchal translucency. J Turk Ger Gynecol Assoc. 2018;19(1):29-33doi: 10.4274/jtgga.2017.0056.
Namlı Kalem, M., Kalem, Z., Bakırarar, B., Ergün, A., & Gürgan, T. (2018). The effect of progesterone use in the first trimester on fetal nuchal translucency. Journal of the Turkish German Gynecological Association, 19(1), 29-33. https://doi.org/10.4274/jtgga.2017.0056
Namlı Kalem, Müberra, et al. "The effect of progesterone use in the first trimester on fetal nuchal translucency." Journal of the Turkish German Gynecological Association vol. 19,1 (2018): 29-33. doi: https://doi.org/10.4274/jtgga.2017.0056
Namlı Kalem M, Kalem Z, Bakırarar B, Ergün A, Gürgan T. The effect of progesterone use in the first trimester on fetal nuchal translucency. J Turk Ger Gynecol Assoc. 2018 Mar 01;19(1):29-33. doi: 10.4274/jtgga.2017.0056. PMID: 29503259; PMCID: PMC5838775.
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J Turk Ger Gynecol Assoc. 2018 Mar 01;19(1):29-33. doi: 10.4274/jtgga.2017.0056.

The effect of progesterone use in the first trimester on fetal nuchal translucency.

Journal of the Turkish German Gynecological Association

Müberra Namlı Kalem, Ziya Kalem, Batuhan Bakırarar, Ali Ergün, Timur Gürgan

Affiliations

  1. Clinic of Obstetrics and Gynecology, Liv Hospital, Ankara, Turkey.
  2. Gürgan Clinic IVF and Women Health Center, Ankara, Turkey.
  3. Department of Biostatistic, Ankara University School of Medicine, Ankara, Turkey.

PMID: 29503259 PMCID: PMC5838775 DOI: 10.4274/jtgga.2017.0056

Abstract

OBJECTIVE: To evaluate the possible association between progesterone use in the first trimester of pregnancy and fetal nuchal translucency (NT).

MATERIAL AND METHODS: This is an observational case-control study, which was conducted with patients who underwent nuchal scans between March 2015 and February 2016 and consequently delivered live and healthy babies. The study group was composed of assisted reproductive technology pregnancies and used intravaginal progesterone 180 mg/day until gestational week 12. The control group comprised pregnant women who became pregnant spontaneously without using any progesterone preparation in the first trimester.

RESULTS: One hundred sixty-four (57.5%) of 285 patients were in the control group and 121 (42.5%) were in the progesterone group. Age, bodyweight, gravidity, and parity number of previous births and abortus, gestational week, crown-rump lengths, free β-human chorionic gonadotropin, pregnancy-associated plasma protein A, and NT values of the progesterone and control groups were recorded and we investigated whether there was a statistically significant difference between the two groups in terms of these parameters; maternal weight was found to be higher in the progesterone group than in the control group and the difference between the groups was statistically significant (p=0.019 and p=0.025). Whether the difference in NT was caused by the effect of maternal weight was investigated using the covariance analysis test and maternal weight was not found to be statistically significant in the model (p=0.284).

CONCLUSION: Fetal NT was increased in the progesterone group compared with the untreated group in healthy pregnancies.

Keywords: Progesterone; assisted reproductive technology pregnancies prenatal screening test.; maternal weight; nuchal translucency

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