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Perazella MA. Pharmacology behind Common Drug Nephrotoxicities. Clin J Am Soc Nephrol. 2018;13(12):1897-1908doi: 10.2215/CJN.00150118.
Perazella, M. A. (2018). Pharmacology behind Common Drug Nephrotoxicities. Clinical journal of the American Society of Nephrology : CJASN, 13(12), 1897-1908. https://doi.org/10.2215/CJN.00150118
Perazella, Mark A. "Pharmacology behind Common Drug Nephrotoxicities." Clinical journal of the American Society of Nephrology : CJASN vol. 13,12 (2018): 1897-1908. doi: https://doi.org/10.2215/CJN.00150118
Perazella MA. Pharmacology behind Common Drug Nephrotoxicities. Clin J Am Soc Nephrol. 2018 Dec 07;13(12):1897-1908. doi: 10.2215/CJN.00150118. Epub 2018 Apr 05. PMID: 29622670; PMCID: PMC6302342.
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Clin J Am Soc Nephrol. 2018 Dec 07;13(12):1897-1908. doi: 10.2215/CJN.00150118. Epub 2018 Apr 05.

Pharmacology behind Common Drug Nephrotoxicities.

Clinical journal of the American Society of Nephrology : CJASN

Mark A Perazella

Affiliations

  1. Section of Nephrology, Department of Medicine, Yale University, New Haven, Connecticut and Veterans Affairs Medical Center, West Haven, Connecticut [email protected].

PMID: 29622670 PMCID: PMC6302342 DOI: 10.2215/CJN.00150118

Abstract

Patients are exposed to numerous prescribed and over-the-counter medications. Unfortunately, drugs remain a relatively common cause of acute and chronic kidney injury. A combination of factors including the innate nephrotoxicity of drugs, underlying patient characteristics that increase their risk for kidney injury, and the metabolism and pathway of excretion by the kidneys of the various agents administered enhance risk for drug-induced nephrotoxicity. This paper will review these clinically relevant aspects of drug-induced nephrotoxicity for the clinical nephrologist.

Copyright © 2018 by the American Society of Nephrology.

Keywords: Acute Kidney Injury; Drug Transporters; Humans; Nephrologists; Nonprescription Drugs; Pharmacology; Proximal Tubulopathy; Renal Elimination; Risk; acute renal failure; drug nephrotoxicity; kidney; metabolism

References

  1. Clin Chim Acta. 2005 Jan;351(1-2):31-47 - PubMed
  2. Clin J Am Soc Nephrol. 2017 Dec 7;12(12):2046-2049 - PubMed
  3. N Engl J Med. 2008 Mar 13;358(11):1129-36 - PubMed
  4. Am J Kidney Dis. 2005 May;45(5):804-17 - PubMed
  5. Kidney Int. 2010 Dec;78(11):1060-3 - PubMed
  6. Clin J Am Soc Nephrol. 2012 Oct;7(10):1713-21 - PubMed
  7. Trends Biotechnol. 2016 Feb;34(2):156-170 - PubMed
  8. J Clin Pharmacol. 2016 Jul;56 Suppl 7:S157-72 - PubMed
  9. Clin J Am Soc Nephrol. 2011 Apr;6(4):856-63 - PubMed
  10. JAMA. 2005 Aug 17;294(7):813-8 - PubMed
  11. Int Urol Nephrol. 2001;32(4):539-47 - PubMed
  12. J Chemother. 2001 Oct;13(5):461-72 - PubMed
  13. J Am Soc Nephrol. 2016 Oct;27(10):2926-2928 - PubMed
  14. J Am Soc Nephrol. 2005 Jun;16(6):1535-6 - PubMed
  15. J Clin Pharmacol. 2006 Apr;46(4):405-7 - PubMed
  16. Curr Med Res Opin. 2007 Aug;23(8):1765-73 - PubMed
  17. Clin Cancer Res. 2005 Feb 15;11(4):1534-8 - PubMed
  18. Am J Kidney Dis. 2007 Aug;50(2):330-5 - PubMed
  19. Kidney Int. 2012 Jun;81(12):1172-8 - PubMed
  20. Am J Med. 1999 Apr;106(4):459-65 - PubMed
  21. J Clin Oncol. 2005 Sep 1;23(25):6117-25 - PubMed
  22. Clin J Am Soc Nephrol. 2009 Jul;4(7):1275-83 - PubMed
  23. Iran J Kidney Dis. 2015 Jan;9(1):3-13 - PubMed
  24. Nat Rev Nephrol. 2010 Aug;6(8):461-70 - PubMed
  25. Am J Kidney Dis. 2016 Aug;68(2):287-291 - PubMed
  26. Expert Opin Drug Saf. 2007 Sep;6(5):547-57 - PubMed
  27. Crit Care Med. 2018 Jan;46(1):12-20 - PubMed
  28. Nat Rev Cancer. 2006 Feb;6(2):130-40 - PubMed
  29. Kidney Int. 2004 Oct;66(4):1613-21 - PubMed
  30. Crit Care. 2006 Feb;10(1):R27 - PubMed
  31. Cleve Clin J Med. 2002 Apr;69(4):289-90, 293-4, 296-7 passim - PubMed
  32. J Assoc Physicians India. 2003 Oct;51:970-9 - PubMed
  33. Kidney Int. 2009 Nov;76(10):1027-34 - PubMed
  34. Clin Infect Dis. 2005 May 1;40 Suppl 6:S414-21 - PubMed
  35. Intensive Care Med. 2015 Aug;41(8):1411-23 - PubMed
  36. J Clin Invest. 2017 Jan 3;127(1):199-214 - PubMed
  37. Am J Kidney Dis. 2008 Mar;51(3):491-503 - PubMed
  38. Expert Opin Drug Saf. 2005 Jul;4(4):689-706 - PubMed
  39. J Intern Med. 2003 Jun;253(6):643-52 - PubMed
  40. J Am Soc Nephrol. 2005 Jun;16(6):1562-70 - PubMed
  41. J Hepatol. 1995 Feb;22(2):189-96 - PubMed
  42. Pediatr Nephrol. 2005 Jul;20(7):872-85 - PubMed
  43. Am J Med Sci. 2001 Mar;321(3):181-90 - PubMed
  44. Am J Kidney Dis. 2015 Nov;66(5):748-55 - PubMed
  45. Kidney Int Rep. 2016 Aug 24;1(4):288-298 - PubMed
  46. Best Pract Res Clin Anaesthesiol. 2004 Mar;18(1):37-52 - PubMed
  47. Kidney Int. 2008 Dec;74(11):1385-93 - PubMed
  48. Semin Nephrol. 2010 Nov;30(6):570-81 - PubMed
  49. N Engl J Med. 2003 Jul 31;349(5):427-34 - PubMed
  50. Am J Pathol. 2005 Dec;167(6):1477-84 - PubMed
  51. Drug Saf. 2015 Jan;38(1):55-64 - PubMed
  52. Nat Rev Nephrol. 2009 Oct;5(10):563-73 - PubMed
  53. Clin Pharmacokinet. 2003;42(5):493-500 - PubMed
  54. Am J Kidney Dis. 2004 Jul;44(1):1-11 - PubMed
  55. Pharmacogenomics. 2010 Apr;11(4):573-85 - PubMed
  56. Semin Arthritis Rheum. 2004 Dec;34(3):593-601 - PubMed
  57. Integr Biol (Camb). 2013 Sep;5(9):1119-29 - PubMed
  58. Micromachines (Basel). 2016 Jul 20;7(7): - PubMed
  59. Medicine (Baltimore). 2014 Nov;93(24):333-9 - PubMed
  60. Kidney Int. 2016 Sep;90(3):638-47 - PubMed
  61. Nat Rev Nephrol. 2014 Jun;10(6):314-24 - PubMed
  62. Clin Exp Nephrol. 2005 Sep;9(3):195-205 - PubMed
  63. J Am Soc Nephrol. 2017 Jun;28(6):1723-1728 - PubMed
  64. N Engl J Med. 2009 Mar 12;360(11):1157-8 - PubMed
  65. J Biol Chem. 2003 Apr 11;278(15):12605-8 - PubMed
  66. Kidney Int. 2016 Sep;90(3):474-6 - PubMed
  67. J Am Soc Nephrol. 2006 Oct;17(10):2919-27 - PubMed
  68. Adolesc Med Clin. 2005 Feb;16(1):31-43, x - PubMed
  69. Kidney Int. 2015 May;87(5):909-17 - PubMed
  70. Kidney Int. 2003 Jul;64(1):281-9 - PubMed
  71. Am J Med Sci. 2003 Jun;325(6):349-62 - PubMed
  72. AIDS. 2006 Feb 28;20(4):561-5 - PubMed
  73. Minerva Urol Nefrol. 2009 Sep;61(3):215-33 - PubMed
  74. Nat Biotechnol. 2010 May;28(5):436-40 - PubMed
  75. Drug Metab Pharmacokinet. 2004 Jun;19(3):159-70 - PubMed
  76. J Infect Dis. 2006 Dec 1;194(11):1481-91 - PubMed
  77. Am J Med. 2009 Apr;122(4):322-8 - PubMed
  78. Clin Cancer Res. 2014 Aug 1;20(15):4026-35 - PubMed
  79. Am J Med Sci. 2011 Mar;341(3):215-21 - PubMed

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