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Garces de Los Fayos Alonso I, Liang HC, Turner SD, et al. The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas. Cancers (Basel). 2018;10(4)doi: 10.3390/cancers10040093.
Garces de Los Fayos Alonso, I., Liang, H. C., Turner, S. D., Lagger, S., Merkel, O., & Kenner, L. (2018). The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas. Cancers, 10(4), . https://doi.org/10.3390/cancers10040093
Garces de Los Fayos Alonso, Ines, et al. "The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas." Cancers vol. 10,4 (2018). doi: https://doi.org/10.3390/cancers10040093
Garces de Los Fayos Alonso I, Liang HC, Turner SD, Lagger S, Merkel O, Kenner L. The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas. Cancers (Basel). 2018 Mar 28;10(4). doi: 10.3390/cancers10040093. PMID: 29597249; PMCID: PMC5923348.
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Cancers (Basel). 2018 Mar 28;10(4). doi: 10.3390/cancers10040093.

The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas.

Cancers

Ines Garces de Los Fayos Alonso, Huan-Chang Liang, Suzanne D Turner, Sabine Lagger, Olaf Merkel, Lukas Kenner

Affiliations

  1. Ludwig Boltzmann Institute for Cancer Research, 1090 Vienna, Austria. [email protected].
  2. Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria. [email protected].
  3. Clinical Institute of Pathology, Medical University of Vienna, 1090 Vienna, Austria. [email protected].
  4. Clinical Institute of Pathology, Medical University of Vienna, 1090 Vienna, Austria. [email protected].
  5. Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB21QP, UK. [email protected].
  6. Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria. [email protected].
  7. Clinical Institute of Pathology, Medical University of Vienna, 1090 Vienna, Austria. [email protected].
  8. Ludwig Boltzmann Institute for Cancer Research, 1090 Vienna, Austria. [email protected].
  9. Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria. [email protected].
  10. Clinical Institute of Pathology, Medical University of Vienna, 1090 Vienna, Austria. [email protected].

PMID: 29597249 PMCID: PMC5923348 DOI: 10.3390/cancers10040093

Abstract

The Activator Protein-1 (AP-1) transcription factor (TF) family, composed of a variety of members including c-JUN, c-FOS and ATF, is involved in mediating many biological processes such as proliferation, differentiation and cell death. Since their discovery, the role of AP-1 TFs in cancer development has been extensively analysed. Multiple in vitro and in vivo studies have highlighted the complexity of these TFs, mainly due to their cell-type specific homo- or hetero-dimerization resulting in diverse transcriptional response profiles. However, as a result of the increasing knowledge of the role of AP-1 TFs in disease, these TFs are being recognized as promising therapeutic targets for various malignancies. In this review, we focus on the impact of deregulated expression of AP-1 TFs in CD30-positive lymphomas including Classical Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma.

Keywords: Activator Protein-1 (AP-1); Anaplastic Large Cell Lymphoma (ALCL); CD-30; Classical Hodgkin Lymphoma (CHL); Peripheral T-cell Lymphoma (PTCL); Transcription Factors (TFs)

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