Display options
Cite
Patlolla AK, Rondalph J, Tchounwou PB. Biochemical and Histopathological Evaluation of Graphene Oxide in Sprague-Dawley Rats. Austin J Environ Toxicol. 2017;3(1)
Patlolla, A. K., Rondalph, J., & Tchounwou, P. B. (2017). Biochemical and Histopathological Evaluation of Graphene Oxide in Sprague-Dawley Rats. Austin journal of environmental toxicology, 3(1), .
Patlolla, A K, et al. "Biochemical and Histopathological Evaluation of Graphene Oxide in Sprague-Dawley Rats." Austin journal of environmental toxicology vol. 3,1 (2017).
Patlolla AK, Rondalph J, Tchounwou PB. Biochemical and Histopathological Evaluation of Graphene Oxide in Sprague-Dawley Rats. Austin J Environ Toxicol. 2017;3(1). Epub 2017 Dec 07. PMID: 29503980; PMCID: PMC5831506.
Copy Download .nbib Format: NLM
Share it on

Austin J Environ Toxicol. 2017;3(1). Epub 2017 Dec 07.

Biochemical and Histopathological Evaluation of Graphene Oxide in Sprague-Dawley Rats.

Austin journal of environmental toxicology

A K Patlolla, J Rondalph, P B Tchounwou

Affiliations

  1. NIH-RCMI Center for Environmental Health, College of Science Engineering and Technology, Jackson State University, USA.
  2. Department of Biology CSET, Jackson State University, USA.
  3. Jackson Public School, USA.

PMID: 29503980 PMCID: PMC5831506

Abstract

Graphene and its derivatives are promising material for important biomedical applications due to their versatility. A detailed comprehensive study of the toxicity of these materials is required in context with the prospective use in biological setting. We investigated toxicity of Graphene Oxide (GO) in rats following exposure with respect to hepatotoxicity and oxidative stress biomarkers. Four groups of five male rats were orally administered GOs, once a day for five days, with doses of 10, 20 and 40mg/Kg GO. A control group consisted of five rats. Blood and liver were collected 24h after the last treatment following standard protocols. GO's exposure increased induction of Reactive Oxygen Species (ROS), activities of liver enzymes (Alanine ALT, Aspartate AST, Alkaline Phosphates ALP), concentration of Lipid Hydro Peroxide (LHP) and morphological alterations of liver tissue in exposed groups compared to control. The highest two doses, 20 and 40mg/kg, showed statistically significant (

Keywords: Alanine Aminotransferases; Aspartate Aminotransferases; Graphene Oxide; Lipid Hydroperoxide; Reactive Oxygen Species; Sprague-Dawley Rats

References

  1. Small. 2010 Feb 22;6(4):537-44 - PubMed
  2. Environ Health Perspect. 2005 Jul;113(7):823-39 - PubMed
  3. ACS Nano. 2010 Oct 26;4(10):5731-6 - PubMed
  4. J Appl Biochem. 1983 Aug-Oct;5(4-5):293-9 - PubMed
  5. Science. 2006 Feb 3;311(5761):622-7 - PubMed
  6. J Am Chem Soc. 2008 Aug 20;130(33):10876-7 - PubMed
  7. Part Fibre Toxicol. 2005 Oct 06;2:8 - PubMed
  8. Toxicol Sci. 2007 Mar;96(1):2-15 - PubMed
  9. Thromb Haemost. 1987 Dec 18;58(4):1078-84 - PubMed
  10. Nat Commun. 2012 Mar 27;3:763 - PubMed
  11. Science. 2005 May 6;308(5723):804-6 - PubMed
  12. Free Radic Res. 2010 Jan;44(1):1-46 - PubMed
  13. Med Biol. 1984;62(2):71-7 - PubMed
  14. Free Radic Biol Med. 1999 Jan;26(1-2):202-26 - PubMed
  15. Environ Int. 2012 Apr;40:244-55 - PubMed
  16. ACS Nano. 2010 Jul 27;4(7):4317-23 - PubMed
  17. Nano Lett. 2011 Dec 14;11(12):5201-7 - PubMed
  18. Free Radic Biol Med. 2003 Jul 1;35(1):9-16 - PubMed
  19. Arch Toxicol. 2014 Nov;88(11):1987-2012 - PubMed
  20. Chem Res Toxicol. 2014 Feb 17;27(2):159-68 - PubMed
  21. Mol Cell Biochem. 2011 Dec;358(1-2):189-99 - PubMed
  22. Nanoscale Res Lett. 2011 Dec;6(1):8 - PubMed
  23. Environ Health Perspect. 2003 Apr;111(4):455-60 - PubMed
  24. Nano Res. 2008;1(3):203-212 - PubMed
  25. J Appl Toxicol. 2011 Jan;31(1):75-83 - PubMed
  26. ACS Nano. 2012 Jan 24;6(1):736-46 - PubMed
  27. ACS Nano. 2010 Jun 22;4(6):3181-6 - PubMed
  28. Am J Clin Pathol. 1957 Jul;28(1):56-63 - PubMed
  29. Nat Nanotechnol. 2008 Apr;3(4):216-21 - PubMed
  30. World J Surg. 2004 Jul;28(7):671-4 - PubMed

Publication Types

Grant support