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Messina A, Monda V, Sessa F, et al. Sympathetic, Metabolic Adaptations, and Oxidative Stress in Autism Spectrum Disorders: How Far From Physiology?. Front Physiol. 2018;9:261doi: 10.3389/fphys.2018.00261.
Messina, A., Monda, V., Sessa, F., Valenzano, A., Salerno, M., Bitetti, I., Precenzano, F., Marotta, R., Lavano, F., Lavano, S. M., Salerno, M., Maltese, A., Roccella, M., Parisi, L., Ferrentino, R. I., Tripi, G., Gallai, B., Cibelli, G., Monda, M., Messina, G., & Carotenuto, M. (2018). Sympathetic, Metabolic Adaptations, and Oxidative Stress in Autism Spectrum Disorders: How Far From Physiology?. Frontiers in physiology, 9261. https://doi.org/10.3389/fphys.2018.00261
Messina, Antonietta, et al. "Sympathetic, Metabolic Adaptations, and Oxidative Stress in Autism Spectrum Disorders: How Far From Physiology?." Frontiers in physiology vol. 9 (2018): 261. doi: https://doi.org/10.3389/fphys.2018.00261
Messina A, Monda V, Sessa F, Valenzano A, Salerno M, Bitetti I, Precenzano F, Marotta R, Lavano F, Lavano SM, Salerno M, Maltese A, Roccella M, Parisi L, Ferrentino RI, Tripi G, Gallai B, Cibelli G, Monda M, Messina G, Carotenuto M. Sympathetic, Metabolic Adaptations, and Oxidative Stress in Autism Spectrum Disorders: How Far From Physiology?. Front Physiol. 2018 Mar 22;9:261. doi: 10.3389/fphys.2018.00261. eCollection 2018. PMID: 29623047; PMCID: PMC5874307.
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Front Physiol. 2018 Mar 22;9:261. doi: 10.3389/fphys.2018.00261. eCollection 2018.

Sympathetic, Metabolic Adaptations, and Oxidative Stress in Autism Spectrum Disorders: How Far From Physiology?.

Frontiers in physiology

Antonietta Messina, Vincenzo Monda, Francesco Sessa, Anna Valenzano, Monica Salerno, Ilaria Bitetti, Francesco Precenzano, Rosa Marotta, Francesco Lavano, Serena M Lavano, Margherita Salerno, Agata Maltese, Michele Roccella, Lucia Parisi, Roberta I Ferrentino, Gabriele Tripi, Beatrice Gallai, Giuseppe Cibelli, Marcellino Monda, Giovanni Messina, Marco Carotenuto

Affiliations

  1. Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.
  2. Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
  3. Clinic of Child and Adolescent Neuropsychiatry, Department of Mental Health, Physical and Preventive Medicine, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.
  4. Department of Health Sciences, University "Magna Graecia", Catanzaro, Italy.
  5. Child Neuropsychiatry, Department of Psychology and Pedagogical Sciences, University of Palermo, Palermo, Italy.
  6. Childhood Psychiatric Service for Neurodevelopmentals Disorders, Chinon, France.
  7. Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy.

PMID: 29623047 PMCID: PMC5874307 DOI: 10.3389/fphys.2018.00261

Abstract

Autism spectrum disorders (ASD) is a complex and multifaceted neurobehavioral syndrome with no specific cause still identified, despite the worldwide increasing (prevalence for 1,000 children from 6.7 to 14.6, between 2000 and 2012). Many biological and instrumental markers have been suggested as potential predictive factors for the precocious diagnosis during infancy and/or pediatric age. Many studies reported structural and functional abnormalities in the autonomic system in subjects with ASD. Sleep problems in ASD are a prominent feature, having an impact on the social interaction of the patient. Considering the role of orexins (A and B) in wake-sleep circadian rhythm, we could speculate that ASD subjects may present a dysregulation in orexinergic neurotransmission. Conversely, oxidative stress is implicated in the pathophysiology of many neurological disorders. Nonetheless, little is known about the linkage between oxidative stress and the occurrence or the progress of autism and autonomic functioning; some markers, such as heart rate (HR), heart rate variability (HRV), body temperature, and galvanic skin response (GSR), may be altered in the patient with this so complex disorder. In the present paper, we analyzed an autism case report, focusing on the rule of the sympathetic activity with the aim to suggest that it may be considered an important tool in ASD evaluation. The results of this case confirm our hypothesis even if further studies needed.

Keywords: Orexin-A; autism spectrum disorders (ASD); heart rate (HR); heart rate variability (HRV); oxidative stress

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