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Moslehi A, Farahabadi M, Chavoshzadeh SA, et al. The Effect of Amygdalin on Endoplasmic Reticulum (ER) Stress Induced Hepatic Steatosis in Mice. Malays J Med Sci. 2018;25(1):16-23doi: 10.21315/mjms2018.25.1.3.
Moslehi, A., Farahabadi, M., Chavoshzadeh, S. A., Barati, A., Ababzadeh, S., & Mohammadbeigi, A. (2018). The Effect of Amygdalin on Endoplasmic Reticulum (ER) Stress Induced Hepatic Steatosis in Mice. The Malaysian journal of medical sciences : MJMS, 25(1), 16-23. https://doi.org/10.21315/mjms2018.25.1.3
Moslehi, Azam, et al. "The Effect of Amygdalin on Endoplasmic Reticulum (ER) Stress Induced Hepatic Steatosis in Mice." The Malaysian journal of medical sciences : MJMS vol. 25,1 (2018): 16-23. doi: https://doi.org/10.21315/mjms2018.25.1.3
Moslehi A, Farahabadi M, Chavoshzadeh SA, Barati A, Ababzadeh S, Mohammadbeigi A. The Effect of Amygdalin on Endoplasmic Reticulum (ER) Stress Induced Hepatic Steatosis in Mice. Malays J Med Sci. 2018 Feb;25(1):16-23. doi: 10.21315/mjms2018.25.1.3. Epub 2018 Feb 28. PMID: 29599631; PMCID: PMC5862047.
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Malays J Med Sci. 2018 Feb;25(1):16-23. doi: 10.21315/mjms2018.25.1.3. Epub 2018 Feb 28.

The Effect of Amygdalin on Endoplasmic Reticulum (ER) Stress Induced Hepatic Steatosis in Mice.

The Malaysian journal of medical sciences : MJMS

Azam Moslehi, Mohsen Farahabadi, Sayyed Abdollah Chavoshzadeh, Akram Barati, Shima Ababzadeh, Abolfazl Mohammadbeigi

Affiliations

  1. Cellular& Molecular Research Center, Qom University of Medical Sciences, Qom, Iran.
  2. BSC of Operating Room, Qom University of Medical Sciences, Qom, Iran.
  3. BSC of Nursing, Qom University of Medical Sciences, Qom, Iran.
  4. Research Center for Environmental Pollutants, Qom University of Medical Sciences, Qom, Iran.

PMID: 29599631 PMCID: PMC5862047 DOI: 10.21315/mjms2018.25.1.3

Abstract

BACKGROUND: Endoplasmic reticulum (ER) stress creates abnormalities in the insulin action, inflammatory responses, lipoprotein B100 degradation, and hepatic lipogenesis. Hepatic steatosis leads to a broad spectrum of hepatic disorders such as nonalcoholic fatty liver disease (NAFLD) and NASH. Amygdalin has beneficial effects on asthma, bronchitis, diabetes, and atherosclerosis. We designed this study to evaluate the effect of amygdalin on the ER stress induced hepatic steatosis.

METHODS: Inbred mice received saline, DMSO and amygdalin, as control groups. ER stress was induced by tunicamycin (TM) injection. Amygdalin was administered 1 h before the TM challenge (Amy + TM group). Mice body and liver weights were measured. Hematoxylin and eosin (H&E) and oil red O staining from liver tissue, were performed. Alanin aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride and cholesterol levels were measured.

RESULTS: Histological evaluation revealed that amygdalin was unable to decrease the TM induced liver steatosis; however, ALT and AST levels decreased [ALT: 35.33(2.15) U/L versus 92.33(6.66) U/L; (57.000, (50.63, 63.36),

CONCLUSION: Amygdalin improved the ALT, AST, and lipid serum levels after the TM challenge; however, it could not attenuate hepatic steatosis.

Keywords: ER stress; amygdalin; liver; steatosis; tunicamycin

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