Radiat Oncol J. 2018 Mar;36(1):45-53. doi: 10.3857/roj.2017.00332. Epub 2018 Mar 05.
Prognostic significance of adjuvant radiation therapy in adenocarcinoma of the cecum.
Radiation oncology journal
Sare Hosseini, Ali Mohammad Bananzadeh, Mohammad Mohammadianpanah, Roham Salek, Ali Taghizadeh-Kermani
Affiliations
Affiliations
- Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
- Colorectal Research Center, Department of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran.
PMID: 29506326
PMCID: PMC5903363 DOI: 10.3857/roj.2017.00332
Abstract
PURPOSE: Local recurrence is a common failure pattern in adenocarcinoma of the cecum. This study aimed to investigate the potential role of adjuvant radiation therapy on oncologic outcomes of patients with adenocarcinoma of the cecum.
MATERIALS AND METHODS: This retrospective study was carried out at three large tertiary university hospitals. We analyzed the characteristics, prognostic factors, and survival of 162 patients with adenocarcinoma of the cecum that were treated and followed up between 2000 and 2013. All the patients had undergone a right hemicolectomy and received chemotherapy with (n = 48) or without (n = 114) adjuvant radiation therapy.
RESULTS: The subjects were 65 females and 97 males with a median age of 56 years (range, 17 to 90 years) at diagnosis. The 5-year local control (LC), disease free survival (DFS), and overall survival (OS) rates were 72.7%, 57.2%, and 62.6% respectively. In a multivariate analysis, age, tumor stage, node stage, and adjuvant radiation therapy were determined to be independent prognostic factors. Age more than 55 years (hazard ratio [HR] = 1.0; 95% confidence interval [CI], 0.06-0.32; p = 0.003], T4 stage (HR = 6.8; 95% CI, 3.07-15.36; p < 0.001), node positive disease (HR = 4.2; 95% CI, 1.94-9.13; p < 0.001), and the absence of adjuvant radiation therapy (HR = 3.0; 95% CI, 1.39-6.46; p = 0.005) had a negative influence on OS.
CONCLUSION: Adjuvant radiation therapy significantly improves DFS and OS in patients with adenocarcinoma of the cecum.
Keywords: Adenocarcinoma; Adjuvant radiation therapy; Cecum; Colon; Prognosis
References
- Int J Cancer. 2015 Mar 1;136(5):E359-86 - PubMed
- J Surg Oncol. 2002 Feb;79(2):107-17; discussion 118 - PubMed
- Int J Cancer. 2002 Oct 10;101(5):403-8 - PubMed
- Indian J Cancer. 2005 Jul-Sep;42(3):133-7 - PubMed
- Dis Colon Rectum. 1995 Oct;38(10):1088-92 - PubMed
- Cancer. 1983 Aug 15;52(4):633-6 - PubMed
- Radiother Oncol. 1984 Oct;2(3):209-14 - PubMed
- Ann Surg Oncol. 1996 Sep;3(5):431-6 - PubMed
- Cancer. 1997 Jul 15;80(2):193-7 - PubMed
- Cancer. 1996 Oct 15;78(8):1666-70 - PubMed
- J Clin Oncol. 2009 Jul 1;27(19):3109-16 - PubMed
- Dis Colon Rectum. 1973 Sep-Oct;16(5):371-7 - PubMed
- J Clin Oncol. 2004 Aug 15;22(16):3277-83 - PubMed
- Int J Radiat Oncol Biol Phys. 1983 Mar;9(3):357-60 - PubMed
- J Gastroenterol Hepatol. 2008 Mar;23(3):418-23 - PubMed
- Int J Radiat Oncol Biol Phys. 1984 May;10(5):645-51 - PubMed
- J Clin Oncol. 1993 Jun;11(6):1112-7 - PubMed
- J Clin Oncol. 2007 Jun 1;25(16):2198-204 - PubMed
- Int J Radiat Oncol Biol Phys. 1987 Jun;13(6):843-6 - PubMed
- Int J Radiat Oncol Biol Phys. 1985 Dec;11(12):2067-71 - PubMed
- Ann Surg Oncol. 2016 Mar;23 (3):856-62 - PubMed
- Ann Surg Oncol. 2010 Jun;17(6):1471-4 - PubMed
- Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S101-7 - PubMed
- Am J Clin Oncol. 2009 Dec;32(6):629-38 - PubMed
- Asian Pac J Cancer Prev. 2014;15(20):8951-5 - PubMed
- Int J Radiat Oncol Biol Phys. 1995 May 15;32(2):457-64 - PubMed
- Dis Colon Rectum. 2001 Feb;44(2):251-8 - PubMed
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