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Sejbæk T, Blaabjerg M, Sprogøe P, et al. Reliability and Validity of a Danish Version of the Multiple Sclerosis Neuropsychological Screening Questionnaire. Int J MS Care. 2018;20(1):49-54doi: 10.7224/1537-2073.2017-011.
Sejbæk, T., Blaabjerg, M., Sprogøe, P., & Ravnborg, M. (2018). Reliability and Validity of a Danish Version of the Multiple Sclerosis Neuropsychological Screening Questionnaire. International journal of MS care, 20(1), 49-54. https://doi.org/10.7224/1537-2073.2017-011
Sejbæk, Tobias, et al. "Reliability and Validity of a Danish Version of the Multiple Sclerosis Neuropsychological Screening Questionnaire." International journal of MS care vol. 20,1 (2018): 49-54. doi: https://doi.org/10.7224/1537-2073.2017-011
Sejbæk T, Blaabjerg M, Sprogøe P, Ravnborg M. Reliability and Validity of a Danish Version of the Multiple Sclerosis Neuropsychological Screening Questionnaire. Int J MS Care. 2018 Jan-Feb;20(1):49-54. doi: 10.7224/1537-2073.2017-011. PMID: 29507543; PMCID: PMC5825986.
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Int J MS Care. 2018 Jan-Feb;20(1):49-54. doi: 10.7224/1537-2073.2017-011.

Reliability and Validity of a Danish Version of the Multiple Sclerosis Neuropsychological Screening Questionnaire.

International journal of MS care

Tobias Sejbæk, Morten Blaabjerg, Pippi Sprogøe, Mads Ravnborg

PMID: 29507543 PMCID: PMC5825986 DOI: 10.7224/1537-2073.2017-011

Abstract

BACKGROUND: More than half of all patients with multiple sclerosis (MS) acquire cognitive impairment as part of their disease progression. Because cognitive dysfunction adds substantially to disability and coping strategies, a cost-effective screening tool is needed for cognitive impairment. The Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ) has previously shown good validity in American, Argentinean, and Dutch MS cohorts. We sought to test reliability and validity of a Danish translation of the MSNQ compared with formal neuropsychological testing, and measures of depression and disability, and to compare self-reported cognition with Symbol Digit Modalities Test (SDMT) results.

METHODS: Of 126 patients with MS and their informants tested with the MSNQ, 77 also underwent formal neuropsychological testing. All patients were tested with the SDMT and assessed clinically using the Expanded Disability Status Scale and MS Impairment Scale.

RESULTS: The test-retest reliability of the MSNQ-P was significant (R

CONCLUSIONS: This study does not support use of the MSNQ as a sensitive or valid screening tool for cognitive impairment in Danish patients with MS.

Conflict of interest statement

Dr. Sejbæk served on the scientific advisory boards of Novartis, Biogen, Teva, Merck, and Roche; received travel funding or speaker honoraria from Biogen, Teva, and Novartis; received honoraria from l

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