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Spaulding CN, Klein RD, Schreiber HL, et al. Precision antimicrobial therapeutics: the path of least resistance?. NPJ Biofilms Microbiomes. 2018;4:4doi: 10.1038/s41522-018-0048-3.
Spaulding, C. N., Klein, R. D., Schreiber, H. L., Janetka, J. W., & Hultgren, S. J. (2018). Precision antimicrobial therapeutics: the path of least resistance?. NPJ biofilms and microbiomes, 44. https://doi.org/10.1038/s41522-018-0048-3
Spaulding, Caitlin N, et al. "Precision antimicrobial therapeutics: the path of least resistance?." NPJ biofilms and microbiomes vol. 4 (2018): 4. doi: https://doi.org/10.1038/s41522-018-0048-3
Spaulding CN, Klein RD, Schreiber HL, Janetka JW, Hultgren SJ. Precision antimicrobial therapeutics: the path of least resistance?. NPJ Biofilms Microbiomes. 2018 Feb 27;4:4. doi: 10.1038/s41522-018-0048-3. eCollection 2018. PMID: 29507749; PMCID: PMC5829159.
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NPJ Biofilms Microbiomes. 2018 Feb 27;4:4. doi: 10.1038/s41522-018-0048-3. eCollection 2018.

Precision antimicrobial therapeutics: the path of least resistance?.

NPJ biofilms and microbiomes

Caitlin N Spaulding, Roger D Klein, Henry L Schreiber, James W Janetka, Scott J Hultgren

Affiliations

  1. 1Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, MA 02115 USA.
  2. 2Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110 USA.
  3. 3Center for Women's Infectious Disease Research (CWIDR), Washington University School of Medicine, St. Louis, MO 63110 USA.
  4. 4Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110 USA.

PMID: 29507749 PMCID: PMC5829159 DOI: 10.1038/s41522-018-0048-3

Abstract

The emergence of drug-resistant pathogens has led to a decline in the efficacy of traditional antimicrobial therapy. The rise in resistance has been driven by widespread use, and in some cases misuse, of antibacterial agents in treating a variety of infections. A growing body of research has begun to elucidate the harmful effects of broad-spectrum antibiotic therapy on the beneficial host microbiota. To combat these threats, increasing effort is being directed toward the development of precision antimicrobial therapeutics that target key virulence determinants of specific pathogens while leaving the remainder of the host microbiota undisturbed. This includes the recent development of small molecules termed "mannosides" that specifically target uropathogenic

Conflict of interest statement

S.J.H. and J.W.J. have ownership interest in Fimbrion Therapeutics, and may benefit if the company is successful in marketing mannosides. The remaining authors declare no competing interests.

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