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Jokar A, Babaei M, Pourmatin S, et al. Effects of Intravenous and Inhaled Nebulized Lignocaine on the Hemodynamic Response of Endotracheal Intubation Patients: A Randomized Clinical Trial. Anesth Essays Res. 2018;12(1):159-164doi: 10.4103/aer.AER_75_17.
Jokar, A., Babaei, M., Pourmatin, S., Taheri, M., Almasi-Hashiani, A., & Yazdanbakhsh, A. (2018). Effects of Intravenous and Inhaled Nebulized Lignocaine on the Hemodynamic Response of Endotracheal Intubation Patients: A Randomized Clinical Trial. Anesthesia, essays and researches, 12(1), 159-164. https://doi.org/10.4103/aer.AER_75_17
Jokar, Abolfazl, et al. "Effects of Intravenous and Inhaled Nebulized Lignocaine on the Hemodynamic Response of Endotracheal Intubation Patients: A Randomized Clinical Trial." Anesthesia, essays and researches vol. 12,1 (2018): 159-164. doi: https://doi.org/10.4103/aer.AER_75_17
Jokar A, Babaei M, Pourmatin S, Taheri M, Almasi-Hashiani A, Yazdanbakhsh A. Effects of Intravenous and Inhaled Nebulized Lignocaine on the Hemodynamic Response of Endotracheal Intubation Patients: A Randomized Clinical Trial. Anesth Essays Res. 2018 Jan-Mar;12(1):159-164. doi: 10.4103/aer.AER_75_17. PMID: 29628574; PMCID: PMC5872855.
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Anesth Essays Res. 2018 Jan-Mar;12(1):159-164. doi: 10.4103/aer.AER_75_17.

Effects of Intravenous and Inhaled Nebulized Lignocaine on the Hemodynamic Response of Endotracheal Intubation Patients: A Randomized Clinical Trial.

Anesthesia, essays and researches

Abolfazl Jokar, Maryam Babaei, Sahar Pourmatin, Majid Taheri, Amir Almasi-Hashiani, Arash Yazdanbakhsh

Affiliations

  1. Department of Medical Emergency, Arak University of Medical Sciences, Arak, Iran.
  2. Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  3. Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

PMID: 29628574 PMCID: PMC5872855 DOI: 10.4103/aer.AER_75_17

Abstract

BACKGROUND: Endotracheal intubation is one of the most common measures in the Intensive Care Unit (ICU) which plays an important role in airway management of the critically ill patients.

AIMS: The study aimed to evaluate the effects of lignocaine spray on hemodynamic response of endotracheal intubation patients.

SETTINGS AND DESIGN: This study is a randomized clinical trial on a study population comprising patients admitted to the ICU.

SUBJECTS AND METHODS: The patients were divided into three groups using a permuted block randomization. In Group 1, inhaled nebulized lignocaine 4% (75.0 mg/kg) was sprayed around the patients' epiglottis and larynx. In Group 2, intravenous (IV) lignocaine 2% (75.0/mg/kg) was injected. No lignocaine was prescribed for or administered to the control group. One and four minutes after intubation, the patients' hemodynamic and vital signs were measured.

STATISTICAL ANALYSIS USED: Data analysis was run using Stata 13 software through repeated measure ANOVA tests.

RESULTS: Although the mean arterial blood pressure (MAP) of Group 1 (inhaled nebulized lignocaine) was smaller than that of Group 2 (IV lignocaine), there was no significant difference between the two groups. Both groups' MAPs were significantly different from that of the control group. As for the average number of pulses, a significant difference was observed between the inhaled and IV lignocaine groups; hence, the average number of pulses in Group 1 (inhalation) was lower than that of Group 2 (IV injection).

CONCLUSION: As blood pressure is considered to be normal under 140/90 and may not entail any hemodynamic complications, it can be concluded that inhaled nebulized lignocaine can control the hemodynamic changes of intubation more effectively than IV lignocaine.

Keywords: Endotracheal intubation; hemodynamics; lignocaine

Conflict of interest statement

There are no conflicts of interest.

References

  1. J Anesth. 2014 Oct;28(5):668-75 - PubMed
  2. J Indian Med Assoc. 2013 Oct;111(10):692-6 - PubMed
  3. Emerg Med J. 2004 May;21(3):296-301 - PubMed
  4. Korean J Anesthesiol. 2011 Jun;60(6):422-7 - PubMed
  5. Anesthesiol Res Pract. 2014;2014:170247 - PubMed
  6. Braz J Anesthesiol. 2013 May-Jun;63(3):235-44 - PubMed
  7. Can J Anaesth. 1989 Jul;36(4):370-6 - PubMed
  8. Chest. 2007 Nov;132(5):1714; author reply 1714-5 - PubMed
  9. Acta Anaesthesiol Sin. 1996 Jun;34(2):61-7 - PubMed
  10. Crit Care Med. 1984 Apr;12(4):391-4 - PubMed
  11. Braz J Anesthesiol. 2014 Jul-Aug;64(4):247-52 - PubMed
  12. Clin Drug Investig. 2007;27(4):269-77 - PubMed

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