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Miniaci MC, De Leonibus E. Missing the egocentric spatial reference: a blank on the map. F1000Res. 2018;7:168doi: 10.12688/f1000research.13675.1.
Miniaci, M. C., & De Leonibus, E. (2018). Missing the egocentric spatial reference: a blank on the map. F1000Research, 7168. https://doi.org/10.12688/f1000research.13675.1
Miniaci, Maria Concetta, and De Leonibus, Elvira. "Missing the egocentric spatial reference: a blank on the map." F1000Research vol. 7 (2018): 168. doi: https://doi.org/10.12688/f1000research.13675.1
Miniaci MC, De Leonibus E. Missing the egocentric spatial reference: a blank on the map. F1000Res. 2018 Feb 09;7:168. doi: 10.12688/f1000research.13675.1. eCollection 2018. PMID: 29568496; PMCID: PMC5840622.
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F1000Res. 2018 Feb 09;7:168. doi: 10.12688/f1000research.13675.1. eCollection 2018.

Missing the egocentric spatial reference: a blank on the map.

F1000Research

Maria Concetta Miniaci, Elvira De Leonibus

Affiliations

  1. Department of Pharmacy , School of Medicine, University of Naples Federico II, Naples, Italy.
  2. Institute of Genetics and Biophysics (IGB) , National Research Council, Naples, Italy.
  3. Telethon Institute of Genetics and Medicine, Telethon Foundation, Pozzuoli, Italy.

PMID: 29568496 PMCID: PMC5840622 DOI: 10.12688/f1000research.13675.1

Abstract

Egocentric (self-centered) and allocentric (viewpoint independent) representations of space are essential for spatial navigation and wayfinding. Deficits in spatial memory come with age-related cognitive decline, are marked in mild cognitive impairment (MCI) and Alzheimer's disease (AD), and are associated with cognitive deficits in autism. In most of these disorders, a change in the brain areas engaged in the spatial reference system processing has been documented. However, the spatial memory deficits observed during physiological and pathological aging are quite different. While patients with AD and MCI have a general spatial navigation impairment in both allocentric and egocentric strategies, healthy older adults are particularly limited in the allocentric navigation, but they can still count on egocentric navigation strategy to solve spatial tasks. Therefore, specific navigational tests should be considered for differential diagnosis between healthy and pathological aging conditions. Finally, more research is still needed to better understand the spatial abilities of autistic individuals.

Keywords: Alzheimer’s disease; aging; autism.; egocentric navigation; posterior parietal cortex; striatum

Conflict of interest statement

No competing interests were disclosed.

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