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Garrido-Gil P, Dominguez-Meijide A, Moratalla R, et al. Aging-related dysregulation in enteric dopamine and angiotensin system interactions: implications for gastrointestinal dysfunction in the elderly. Oncotarget. 2018;9(13):10834-10846doi: 10.18632/oncotarget.24330.
Garrido-Gil, P., Dominguez-Meijide, A., Moratalla, R., Guerra, M. J., & Labandeira-Garcia, J. L. (2018). Aging-related dysregulation in enteric dopamine and angiotensin system interactions: implications for gastrointestinal dysfunction in the elderly. Oncotarget, 9(13), 10834-10846. https://doi.org/10.18632/oncotarget.24330
Garrido-Gil, Pablo, et al. "Aging-related dysregulation in enteric dopamine and angiotensin system interactions: implications for gastrointestinal dysfunction in the elderly." Oncotarget vol. 9,13 (2018): 10834-10846. doi: https://doi.org/10.18632/oncotarget.24330
Garrido-Gil P, Dominguez-Meijide A, Moratalla R, Guerra MJ, Labandeira-Garcia JL. Aging-related dysregulation in enteric dopamine and angiotensin system interactions: implications for gastrointestinal dysfunction in the elderly. Oncotarget. 2018 Jan 29;9(13):10834-10846. doi: 10.18632/oncotarget.24330. eCollection 2018 Feb 16. PMID: 29541380; PMCID: PMC5834264.
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Oncotarget. 2018 Jan 29;9(13):10834-10846. doi: 10.18632/oncotarget.24330. eCollection 2018 Feb 16.

Aging-related dysregulation in enteric dopamine and angiotensin system interactions: implications for gastrointestinal dysfunction in the elderly.

Oncotarget

Pablo Garrido-Gil, Antonio Dominguez-Meijide, Rosario Moratalla, Maria J Guerra, Jose L Labandeira-Garcia

Affiliations

  1. Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Research Center for Molecular Medicine and Chronic Diseases, University of Santiago de Compostela, Santiago de Compostela, Spain.
  2. Networking Research Centre on Neurodegenerative Diseases, Madrid, Spain.
  3. Instituto Cajal, Madrid, Spain.

PMID: 29541380 PMCID: PMC5834264 DOI: 10.18632/oncotarget.24330

Abstract

Gastrointestinal dysfunction is a common problem in the elderly. Aging-related changes in interactions between local dopaminergic and renin-angiotensin systems (RAS) have been observed in the brain, renal and vascular tissues. However, it is not known if these interactions also occur in the gut, and are dysregulated with aging. We showed a mutual regulation between the colonic dopaminergic system and RAS using young and aged mice deficient for major angiotensin and dopamine receptors. Aged rats showed a marked decrease in colonic dopamine D2 receptor expression, together with an increase in angiotensin type 1 (AT1) receptor expression, a decrease in angiotensin type 2 (AT2) receptor expression (i.e. an increase in the RAS pro-inflammatory arm activity), and increased levels of inflammatory and oxidative markers. Aged rats also showed increased levels of colonic dopamine and noradrenalin, and a marked decrease in acetylcholine and serotonin levels. The present observations contribute to explain an aging-related pro-inflammatory state and dysregulation in gastrointestinal function, which may be counteracted by treatment of aged animals with the AT1 receptor blocker candesartan.

Keywords: Gerotarget; aged; colon; gut; inflammation; neurotransmitters

Conflict of interest statement

CONFLICTS OF INTEREST The authors have no actual or potential conflicts of interest to declare.

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