Display options
Cite
Kohe SE, Bennett CD, Gill SK, et al. Metabolic profiling of the three neural derived embryonal pediatric tumors retinoblastoma, neuroblastoma and medulloblastoma, identifies distinct metabolic profiles. Oncotarget. 2018;9(13):11336-11351doi: 10.18632/oncotarget.24168.
Kohe, S. E., Bennett, C. D., Gill, S. K., Wilson, M., McConville, C., & Peet, A. C. (2018). Metabolic profiling of the three neural derived embryonal pediatric tumors retinoblastoma, neuroblastoma and medulloblastoma, identifies distinct metabolic profiles. Oncotarget, 9(13), 11336-11351. https://doi.org/10.18632/oncotarget.24168
Kohe, Sarah E, et al. "Metabolic profiling of the three neural derived embryonal pediatric tumors retinoblastoma, neuroblastoma and medulloblastoma, identifies distinct metabolic profiles." Oncotarget vol. 9,13 (2018): 11336-11351. doi: https://doi.org/10.18632/oncotarget.24168
Kohe SE, Bennett CD, Gill SK, Wilson M, McConville C, Peet AC. Metabolic profiling of the three neural derived embryonal pediatric tumors retinoblastoma, neuroblastoma and medulloblastoma, identifies distinct metabolic profiles. Oncotarget. 2018 Jan 11;9(13):11336-11351. doi: 10.18632/oncotarget.24168. eCollection 2018 Feb 16. PMID: 29541417; PMCID: PMC5834290.
Copy Download .nbib Format: NLM
Share it on

Oncotarget. 2018 Jan 11;9(13):11336-11351. doi: 10.18632/oncotarget.24168. eCollection 2018 Feb 16.

Metabolic profiling of the three neural derived embryonal pediatric tumors retinoblastoma, neuroblastoma and medulloblastoma, identifies distinct metabolic profiles.

Oncotarget

Sarah E Kohe, Christopher D Bennett, Simrandip K Gill, Martin Wilson, Carmel McConville, Andrew C Peet

Affiliations

  1. Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.
  2. Birmingham Children's Hospital, NHS Foundation Trust, Birmingham, United Kingdom.
  3. Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, United Kingdom.

PMID: 29541417 PMCID: PMC5834290 DOI: 10.18632/oncotarget.24168

Abstract

The rare pediatric embryonal tumors retinoblastoma, medulloblastoma and neuroblastoma derive from neuroectodermal tissue and share similar histopathological features despite different anatomical locations and diverse clinical outcomes. As metabolism can reflect genetic and histological features, we investigated whether the metabolism of embryonal tumors reflects their similar histology, shared developmental and neural origins, or tumor location. We undertook metabolic profiling on 50 retinoblastoma, 39 medulloblastoma and 70 neuroblastoma using high resolution magic angle spinning magnetic resonance spectroscopy (1H-MRS). Mean metabolite concentrations identified several metabolites that were significantly different between the tumor groups including taurine, hypotaurine, glutamate, glutamine, GABA, phosphocholine, N-acetylaspartate, creatine, glycine and myoinositol,

Keywords: high resolution magnetic resonance spectroscopy; medulloblastoma; neuroblastoma; retinoblastoma; tumor metabolites

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that they have no competing or conflicting interests.

References

  1. Nucleic Acids Res. 2015 Jul 1;43(W1):W251-7 - PubMed
  2. Invest Ophthalmol Vis Sci. 2004 Apr;45(4):1272-80 - PubMed
  3. Cell Metab. 2012 Feb 8;15(2):157-70 - PubMed
  4. Neuro Oncol. 2014 Aug;16(8):1137-45 - PubMed
  5. Neurochem Res. 2010 Dec;35(12):1939-43 - PubMed
  6. Eur J Cancer. 2013 Jan;49(2):457-64 - PubMed
  7. BBA Clin. 2016 Apr 12;5:170-8 - PubMed
  8. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10450-5 - PubMed
  9. NMR Biomed. 1997 Jan;10(1):2-12 - PubMed
  10. Stem Cell Res. 2012 Jul;9(1):24-34 - PubMed
  11. Nat Rev Cancer. 2011 Nov 17;11(12):835-48 - PubMed
  12. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6408-13 - PubMed
  13. ScientificWorldJournal. 2014;2014:546192 - PubMed
  14. PLoS One. 2014 May 23;9(5):e97285 - PubMed
  15. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6181-6 - PubMed
  16. Metabolites. 2016 Mar 22;6(1):null - PubMed
  17. Cancer Res. 2016 Aug 15;76(16):4608-18 - PubMed
  18. Breast Cancer Res. 2014 Jan 21;16(1):R5 - PubMed
  19. AJNR Am J Neuroradiol. 2006 Mar;27(3):488-92 - PubMed
  20. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10258-63 - PubMed
  21. Cancer. 1999 Jul 15;86(2):364-72 - PubMed
  22. Neural Dev. 2013 Jun 18;8:12 - PubMed
  23. Nat Protoc. 2011 Jun;6(6):743-60 - PubMed
  24. PLoS One. 2013 Apr 17;8(4):e61578 - PubMed
  25. J Clin Invest. 2013 Sep;123(9):3678-84 - PubMed
  26. J Gen Physiol. 1981 Jun;77(6):667-92 - PubMed
  27. Nucleic Acids Res. 2013 Jan;41(Database issue):D801-7 - PubMed
  28. Science. 2012 May 25;336(6084):1040-4 - PubMed
  29. Physiology (Bethesda). 2009 Jun;24:171-85 - PubMed
  30. Clin Cancer Res. 2014 Sep 1;20(17 ):4532-9 - PubMed
  31. Clin Cancer Res. 2012 Aug 15;18(16):4240-6 - PubMed
  32. Curr Top Dev Biol. 2011;94:77-127 - PubMed
  33. CA Cancer J Clin. 2014 Mar-Apr;64(2):83-103 - PubMed
  34. Oncogene. 2015 Oct 8;34(41):5207-15 - PubMed
  35. NMR Biomed. 2007 Nov;20(7):692-700 - PubMed
  36. Pediatr Res. 1999 Oct;46(4):474-85 - PubMed
  37. Int J Mol Med. 2010 Dec;26(6):941-8 - PubMed
  38. Endocr Relat Cancer. 2013 Aug 28;20(5):705-16 - PubMed
  39. Neoplasia. 2015 Jan;17(1):55-65 - PubMed
  40. J Natl Cancer Inst. 2016 Jan 26;108(6):djv426 - PubMed
  41. J Clin Pathol. 2004 Jun;57(6):561-76 - PubMed
  42. Magn Reson Med. 2005 May;53(5):1018-24 - PubMed
  43. Oncogene. 2006 Aug 28;25(38):5341-9 - PubMed
  44. NMR Biomed. 2010 Jan;23(1):80-7 - PubMed
  45. Pediatr Blood Cancer. 2011 Jan;56(1):24-34 - PubMed
  46. Front Endocrinol (Lausanne). 2012 Feb 16;3:22 - PubMed
  47. Curr Top Med Chem. 2011;11(1):2-26 - PubMed
  48. Science. 2013 Aug 23;341(6148):860-3 - PubMed
  49. Radiother Oncol. 2016 Feb;118(2):393-8 - PubMed
  50. Eye (Lond). 2016 Jun;30(6):773-83 - PubMed
  51. Mol Cancer. 2009 Feb 10;8:6 - PubMed
  52. Nat Rev Cancer. 2005 Jun;5(6):481-8 - PubMed
  53. NMR Biomed. 2000 May;13(3):129-53 - PubMed
  54. Acta Neuropathol. 2012 Apr;123(4):473-84 - PubMed
  55. Br J Cancer. 2015 Oct 20;113(8):1216-24 - PubMed
  56. J Neurochem. 2002 Aug;82(4):736-54 - PubMed
  57. Prog Neurobiol. 2007 Feb;81(2):89-131 - PubMed

Publication Types