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J Clin Med Res. 2018 Apr;10(4):351-357. doi: 10.14740/jocmr3106w. Epub 2018 Feb 18.

Cardiorespiratory Failure in Thyroid Storm: Case Report and Literature Review.

Journal of clinical medicine research

Qiang Nai, Mohammad Ansari, Stella Pak, Yufei Tian, Mohammed Amzad-Hossain, Yanhong Zhang, Yali Lou, Shuvendu Sen, Mohammed Islam

Affiliations

  1. Department of Medicine, University of Toledo Medical Center, Toledo, OH 43614, USA.
  2. These authors contributed equally.
  3. Internal Medicine, Raritan Bay Medical Center, Perth Amboy, NJ 08861, USA.
  4. Department of Nephrology, New York Presbyterian Queens, 56-45 Main Street, Flushing, NY 11355, USA.
  5. Department of Pulmonary and Critical Care, Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, USA.
  6. Department of Neurology, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA.

PMID: 29511425 PMCID: PMC5827921 DOI: 10.14740/jocmr3106w

Abstract

Thyroid storm is a potentially fatal manifestation of thyrotoxicosis. Cardiopulmonary failure is the most common cause of death in thyroid storm. Clinicians should keep in mind that thyroid storm complicated with cardiopulmonary failure can be the first presentation of thyrotoxicosis. As early intervention is associated with improved patient outcome, prompt diagnosis based on clinical grounds is of paramount importance in the management of thyrotoxicosis. A high index of suspicion and the ability of early recognition of impending thyroid storm depends on a thorough knowledge of both the typical and atypical clinical features of this illness. Herein, we report a case of thyroid storm presenting as cardiopulmonary failure in a 51-year-old woman with undiagnosed Grave's disease. Additionally, we review the pathophysiology of cardiopulmonary failure associated with thyrotoxicosis and various treatment modalities for thyroid storm.

Keywords: Cardiopulmonary failure; Grave’s disease; Thyroid storm; Thyrotoxicosis

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