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Paik J, Treuting PM, Haenisch M, et al. Can inhibition of retinoic acid biosynthesis function as a non-hormonal female contraceptive?. Contraception. 2018;doi: 10.1016/j.contraception.2018.03.035.
Paik, J., Treuting, P. M., Haenisch, M., & Amory, J. K. (2018). Can inhibition of retinoic acid biosynthesis function as a non-hormonal female contraceptive?. Contraception, . https://doi.org/10.1016/j.contraception.2018.03.035
Paik, Jisun, et al. "Can inhibition of retinoic acid biosynthesis function as a non-hormonal female contraceptive?." Contraception vol. (2018). doi: https://doi.org/10.1016/j.contraception.2018.03.035
Paik J, Treuting PM, Haenisch M, Amory JK. Can inhibition of retinoic acid biosynthesis function as a non-hormonal female contraceptive?. Contraception. 2018 Apr 07; doi: 10.1016/j.contraception.2018.03.035. Epub 2018 Apr 07. PMID: 29630869; PMCID: PMC6174106.
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Contraception. 2018 Apr 07; doi: 10.1016/j.contraception.2018.03.035. Epub 2018 Apr 07.

Can inhibition of retinoic acid biosynthesis function as a non-hormonal female contraceptive?.

Contraception

Jisun Paik, Piper M Treuting, Michael Haenisch, John K Amory

Affiliations

  1. Department of Comparative Medicine, University of Washington, Seattle, WA, USA. Electronic address: [email protected].
  2. Department of Comparative Medicine, University of Washington, Seattle, WA, USA.
  3. Department of Medicine, University of Washington, Seattle, WA, USA.

PMID: 29630869 PMCID: PMC6174106 DOI: 10.1016/j.contraception.2018.03.035

Abstract

OBJECTIVE: Vitamin A deficient females have reduced fertility due to decreased retinoic acid production. WIN 18,446 inhibits retinoic acid biosynthesis and functions as a contraceptive in males. We tested whether WIN 18,446 treatment would suppress fertility in female mice.

STUDY DESIGN: Female mice were treated with WIN 18,446 and mated. Pregnancy rates were compared using Fisher's exact test.

RESULTS: WIN 18,446 reduced pregnancy compared with control (p=.03). However, one animal became pregnant with malformed embryos.

CONCLUSIONS: WIN 18,446 treatment significantly reduces fecundity, but teratogenicity in the setting of contraceptive failure limits the appeal of this approach to female contraception.

Copyright © 2018 Elsevier Inc. All rights reserved.

Keywords: aldehyde dehydrogenase 1A; enzyme inhibitor; pregnancy; retinoic acid

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