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Margaryan A, Hansen HB, Rasmussen S, et al. Ancient pathogen DNA in human teeth and petrous bones. Ecol Evol. 2018;8(6):3534-3542doi: 10.1002/ece3.3924.
Margaryan, A., Hansen, H. B., Rasmussen, S., Sikora, M., Moiseyev, V., Khoklov, A., Epimakhov, A., Yepiskoposyan, L., Kriiska, A., Varul, L., Saag, L., Lynnerup, N., Willerslev, E., & Allentoft, M. E. (2018). Ancient pathogen DNA in human teeth and petrous bones. Ecology and evolution, 8(6), 3534-3542. https://doi.org/10.1002/ece3.3924
Margaryan, Ashot, et al. "Ancient pathogen DNA in human teeth and petrous bones." Ecology and evolution vol. 8,6 (2018): 3534-3542. doi: https://doi.org/10.1002/ece3.3924
Margaryan A, Hansen HB, Rasmussen S, Sikora M, Moiseyev V, Khoklov A, Epimakhov A, Yepiskoposyan L, Kriiska A, Varul L, Saag L, Lynnerup N, Willerslev E, Allentoft ME. Ancient pathogen DNA in human teeth and petrous bones. Ecol Evol. 2018 Feb 26;8(6):3534-3542. doi: 10.1002/ece3.3924. eCollection 2018 Mar. PMID: 29607044; PMCID: PMC5869295.
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Ecol Evol. 2018 Feb 26;8(6):3534-3542. doi: 10.1002/ece3.3924. eCollection 2018 Mar.

Ancient pathogen DNA in human teeth and petrous bones.

Ecology and evolution

Ashot Margaryan, Henrik B Hansen, Simon Rasmussen, Martin Sikora, Vyacheslav Moiseyev, Alexandr Khoklov, Andrey Epimakhov, Levon Yepiskoposyan, Aivar Kriiska, Liivi Varul, Lehti Saag, Niels Lynnerup, Eske Willerslev, Morten E Allentoft

Affiliations

  1. Centre for GeoGenetics Natural History Museum of Denmark University of Copenhagen Copenhagen Denmark.
  2. Institute of Molecular Biology National Academy of Sciences Yerevan Armenia.
  3. Department of Bio and Health Informatics Technical University of Denmark Kongens Lyngby Denmark.
  4. Peter the Great Museum of Anthropology and Ethnography (Kunstkamera) RASSt Petersburg Russia.
  5. Samara State University of Social Sciences and Education Samara Russia.
  6. Institute of History and Archaeology RAS (South Ural Department) South Ural State University Chelyabinsk Russia.
  7. Russian-Armenian University Yerevan Armenia.
  8. School of Humanities Tallinn University Tallinn Estonia.
  9. Department of Evolutionary Biology Institute of Molecular and Cell Biology University of Tartu Tartu Estonia.
  10. Estonian Biocentre Institute of Genomics University of Tartu Tartu Estonia.
  11. Department of Forensic Medicine Section of Forensic Pathology University of Copenhagen Copenhagen East Denmark.
  12. Department of Zoology University of Cambridge Cambridge UK.
  13. Wellcome Trust Sanger Institute Hinxton Cambridgeshire CB10 1SA UK.

PMID: 29607044 PMCID: PMC5869295 DOI: 10.1002/ece3.3924

Abstract

Recent ancient DNA (aDNA) studies of human pathogens have provided invaluable insights into their evolutionary history and prevalence in space and time. Most of these studies were based on DNA extracted from teeth or postcranial bones. In contrast, no pathogen DNA has been reported from the petrous bone which has become the most desired skeletal element in ancient DNA research due to its high endogenous DNA content. To compare the potential for pathogenic aDNA retrieval from teeth and petrous bones, we sampled these elements from five ancient skeletons, previously shown to be carrying

Keywords: Yersinia pestis; ancient DNA; ancient pathogens; metagenomics; petrous bone; plague

References

  1. Nucleic Acids Res. 2016 Jul 8;44(W1):W58-63 - PubMed
  2. PLoS One. 2015 Jun 18;10(6):e0129102 - PubMed
  3. N Engl J Med. 2014 Jan 23;370(4):334-40 - PubMed
  4. Ann Otol Rhinol Laryngol. 1966 Dec;75(4):921-44 - PubMed
  5. Genome Res. 2014 Sep;24(9):1543-9 - PubMed
  6. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18511-6 - PubMed
  7. Cell. 2015 Oct 22;163(3):571-82 - PubMed
  8. Science. 2016 Jan 8;351(6269):162-165 - PubMed
  9. Nature. 2014 Oct 23;514(7523):494-7 - PubMed
  10. Curr Biol. 2014 Nov 3;24(21):R1035-7 - PubMed
  11. Proc Biol Sci. 2005 Jan 7;272(1558):3-16 - PubMed
  12. Nature. 2015 Jun 11;522(7555):167-72 - PubMed
  13. Sci Rep. 2015 Jun 17;5:11184 - PubMed
  14. BMC Res Notes. 2012 Jul 02;5:337 - PubMed
  15. PLoS Pathog. 2013;9(5):e1003349 - PubMed
  16. Am J Phys Anthropol. 2009 Feb;138(2):199-209 - PubMed
  17. Hum Mutat. 2011 Jan;32(1):25-32 - PubMed
  18. BMC Genomics. 2012 May 10;13:178 - PubMed
  19. BMC Bioinformatics. 2011 Sep 30;12:385 - PubMed
  20. PLoS One. 2017 Jan 27;12 (1):e0170940 - PubMed
  21. Nat Commun. 2014 Oct 21;5:5257 - PubMed
  22. Bioinformatics. 2009 Jul 15;25(14):1754-60 - PubMed
  23. Bone. 1998 Jun;22(6):677-82 - PubMed
  24. Genome Biol. 2014 Mar 03;15(3):R46 - PubMed
  25. Biotechniques. 2015 Aug 01;59(2):87-93 - PubMed
  26. Trends Microbiol. 2016 Dec;24(12 ):978-990 - PubMed
  27. Science. 2013 Jul 12;341(6142):179-83 - PubMed

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