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J Magn Reson Imaging. 2018 Mar 23; doi: 10.1002/jmri.26011. Epub 2018 Mar 23.

Repeatability, reproducibility, and accuracy of quantitative mri of the breast in the community radiology setting.

Journal of magnetic resonance imaging : JMRI

Anna G Sorace, Chengyue Wu, Stephanie L Barnes, Angela M Jarrett, Sarah Avery, Debra Patt, Boone Goodgame, Jeffery J Luci, Hakmook Kang, Richard G Abramson, Thomas E Yankeelov, John Virostko

Affiliations

  1. Department of Diagnostic Medicine, University of Texas at Austin, Austin, Texas, USA.
  2. Livestrong Cancer Institutes, University of Texas at Austin, Austin, Texas, USA.
  3. Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas, USA.
  4. Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin, Texas, USA.
  5. Austin Radiological Association, Austin, Texas, USA.
  6. Texas Oncology, Austin, Texas, USA.
  7. Seton Hospital, Austin, Texas, USA.
  8. Department of Internal Medicine, University of Texas at Austin, Austin, Texas, USA.
  9. Department of Neuroscience, University of Texas at Austin, Austin, Texas, USA.
  10. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  11. Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

PMID: 29570895 PMCID: PMC6151298 DOI: 10.1002/jmri.26011

Abstract

BACKGROUND: Quantitative diffusion-weighted MRI (DW-MRI) and dynamic contrast-enhanced MRI (DCE-MRI) have the potential to impact patient care by providing noninvasive biological information in breast cancer.

PURPOSE/HYPOTHESIS: To quantify the repeatability, reproducibility, and accuracy of apparent diffusion coefficient (ADC) and T

STUDY TYPE: Prospective.

SUBJECTS/PHANTOM: Ice-water DW-MRI and T

FIELD STRENGTH/SEQUENCE: 3T Siemens Skyra MRI quantitative DW-MRI and T

ASSESSMENT: Quantitative DW-MRI and T

STATISTICAL TESTS: Average values of breast tissue were quantified and Bland-Altman analysis was performed to assess the repeatability of the MRI techniques, while the Friedman test assessed reproducibility.

RESULTS: ADC measurements were reproducible across sites, with an average difference of 1.6% in an ice-water phantom and 7.0% in breast fibroglandular tissue. T

DATA CONCLUSION: Community radiology practices can perform repeatable, reproducible, and accurate quantitative T

LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.

© 2018 International Society for Magnetic Resonance in Medicine.

Keywords: T1-mapping; breast cancer; diffusion-weighted MRI; dynamic contrast-enhanced MRI

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