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Witzenburg CM, Holmes JW. A Comparison of Phenomenologic Growth Laws for Myocardial Hypertrophy. J Elast. 2017;129(1):257-281doi: 10.1007/s10659-017-9631-8.
Witzenburg, C. M., & Holmes, J. W. (2017). A Comparison of Phenomenologic Growth Laws for Myocardial Hypertrophy. Journal Of Elasticity, 129(1), 257-281. https://doi.org/10.1007/s10659-017-9631-8
Witzenburg, Colleen M, and Holmes, Jeffrey W. "A Comparison of Phenomenologic Growth Laws for Myocardial Hypertrophy." Journal Of Elasticity vol. 129,1 (2017): 257-281. doi: https://doi.org/10.1007/s10659-017-9631-8
Witzenburg CM, Holmes JW. A Comparison of Phenomenologic Growth Laws for Myocardial Hypertrophy. J Elast. 2017 Dec;129(1):257-281. doi: 10.1007/s10659-017-9631-8. Epub 2017 Mar 01. PMID: 29632418; PMCID: PMC5889094.
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J Elast. 2017 Dec;129(1):257-281. doi: 10.1007/s10659-017-9631-8. Epub 2017 Mar 01.

A Comparison of Phenomenologic Growth Laws for Myocardial Hypertrophy.

Journal Of Elasticity

Colleen M Witzenburg, Jeffrey W Holmes

Affiliations

  1. Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
  2. Department of Medicine, University of Virginia, Charlottesville, VA, USA.
  3. Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA.

PMID: 29632418 PMCID: PMC5889094 DOI: 10.1007/s10659-017-9631-8

Abstract

The heart grows in response to changes in hemodynamic loading during normal development and in response to valve disease, hypertension, and other pathologies. In general, a left ventricle subjected to increased afterload (pressure overloading) exhibits concentric growth characterized by thickening of individual myocytes and the heart wall, while one experiencing increased preload (volume overloading) exhibits eccentric growth characterized by lengthening of myocytes and dilation of the cavity. Predictive models of cardiac growth could be important tools in evaluating treatments, guiding clinical decision making, and designing novel therapies for a range of diseases. Thus, in the past 20 years there has been considerable effort to simulate growth within the left ventricle. While a number of published equations or systems of equations (often termed "growth laws") can capture some aspects of experimentally observed growth patterns, no direct comparisons of the various published models have been performed. Here we examine eight of these laws and compare them in a simple test-bed in which we imposed stretches measured during

Keywords: adaptation; cardiac mechanics; computer model; overload; remodeling; ventricle

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