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Sata Y, Head GA, Denton K, et al. Role of the Sympathetic Nervous System and Its Modulation in Renal Hypertension. Front Med (Lausanne). 2018;5:82doi: 10.3389/fmed.2018.00082.
Sata, Y., Head, G. A., Denton, K., May, C. N., & Schlaich, M. P. (2018). Role of the Sympathetic Nervous System and Its Modulation in Renal Hypertension. Frontiers in medicine, 582. https://doi.org/10.3389/fmed.2018.00082
Sata, Yusuke, et al. "Role of the Sympathetic Nervous System and Its Modulation in Renal Hypertension." Frontiers in medicine vol. 5 (2018): 82. doi: https://doi.org/10.3389/fmed.2018.00082
Sata Y, Head GA, Denton K, May CN, Schlaich MP. Role of the Sympathetic Nervous System and Its Modulation in Renal Hypertension. Front Med (Lausanne). 2018 Mar 29;5:82. doi: 10.3389/fmed.2018.00082. eCollection 2018. PMID: 29651418; PMCID: PMC5884873.
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Front Med (Lausanne). 2018 Mar 29;5:82. doi: 10.3389/fmed.2018.00082. eCollection 2018.

Role of the Sympathetic Nervous System and Its Modulation in Renal Hypertension.

Frontiers in medicine

Yusuke Sata, Geoffrey A Head, Kate Denton, Clive N May, Markus P Schlaich

Affiliations

  1. Neurovascular Hypertension and Kidney Disease Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
  2. Faculty of Medicine, Nursing and Health Sciences, Central Clinical School, Monash University, Melbourne, VIC, Australia.
  3. Neuropharmacology Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
  4. Cardiovascular Program, Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.
  5. Preclinical Critical Care Unit, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
  6. Dobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit, University of Western Australia, Perth, WA, Australia.

PMID: 29651418 PMCID: PMC5884873 DOI: 10.3389/fmed.2018.00082

Abstract

The kidneys are densely innervated with renal efferent and afferent nerves to communicate with the central nervous system. Innervation of major structural components of the kidneys, such as blood vessels, tubules, the pelvis, and glomeruli, forms a bidirectional neural network to relay sensory and sympathetic signals to and from the brain. Renal efferent nerves regulate renal blood flow, glomerular filtration rate, tubular reabsorption of sodium and water, as well as release of renin and prostaglandins, all of which contribute to cardiovascular and renal regulation. Renal afferent nerves complete the feedback loop

Keywords: afferent; central nervous system; hypertension; renal; renal nerve activity; sympathetic nervous system

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