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Mori H, Cardiff RD, Borowsky AD. Aging Mouse Models Reveal Complex Tumor-Microenvironment Interactions in Cancer Progression. Front Cell Dev Biol. 2018;6:35doi: 10.3389/fcell.2018.00035.
Mori, H., Cardiff, R. D., & Borowsky, A. D. (2018). Aging Mouse Models Reveal Complex Tumor-Microenvironment Interactions in Cancer Progression. Frontiers in cell and developmental biology, 635. https://doi.org/10.3389/fcell.2018.00035
Mori, Hidetoshi, et al. "Aging Mouse Models Reveal Complex Tumor-Microenvironment Interactions in Cancer Progression." Frontiers in cell and developmental biology vol. 6 (2018): 35. doi: https://doi.org/10.3389/fcell.2018.00035
Mori H, Cardiff RD, Borowsky AD. Aging Mouse Models Reveal Complex Tumor-Microenvironment Interactions in Cancer Progression. Front Cell Dev Biol. 2018 Mar 29;6:35. doi: 10.3389/fcell.2018.00035. eCollection 2018. PMID: 29651417; PMCID: PMC5884881.
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Front Cell Dev Biol. 2018 Mar 29;6:35. doi: 10.3389/fcell.2018.00035. eCollection 2018.

Aging Mouse Models Reveal Complex Tumor-Microenvironment Interactions in Cancer Progression.

Frontiers in cell and developmental biology

Hidetoshi Mori, Robert D Cardiff, Alexander D Borowsky

Affiliations

  1. Center for Comparative Medicine, University of California, Davis, Davis, CA, United States.
  2. Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Davis, CA, United States.

PMID: 29651417 PMCID: PMC5884881 DOI: 10.3389/fcell.2018.00035

Abstract

Mouse models and genetically engineered mouse models (GEMM) are essential experimental tools for the understanding molecular mechanisms within complex biological systems. GEMM are especially useful for inferencing phenocopy information to genetic human diseases such as breast cancer. Human breast cancer modeling in mice most commonly employs mammary epithelial-specific promoters to investigate gene function(s) and, in particular, putative oncogenes. Models are specifically useful in the mammary epithelial cell in the context of the complete mammary gland environment. Gene targeted knockout mice including conditional targeting to specific mammary cells can reveal developmental defects in mammary organogenesis and demonstrate the importance of putative tumor suppressor genes. Some of these models demonstrate a non-traditional type of tumor suppression which involves interplay between the tumor susceptible cell and its host/environment. These GEMM help to reveal the processes of cancer progression beyond those intrinsic to cancer cells. Furthermore, the, analysis of mouse models requires appropriate consideration of mouse strain, background, and environmental factors. In this review, we compare aging-related factors in mouse models for breast cancer. We introduce databases of GEMM attributes and colony functional variations.

Keywords: aging; gene knockout mice; genetically engineered mouse models (GEMMs); mammary tumorigenesis; mouse strain

References

  1. EMBO J. 2008 Mar 19;27(6):910-20 - PubMed
  2. Int J Cancer. 1998 Aug 12;77(4):640-4 - PubMed
  3. Immunity. 2001 Oct;15(4):521-31 - PubMed
  4. Exp Toxicol Pathol. 2001 Sep;53(4):247-55 - PubMed
  5. Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8551-6 - PubMed
  6. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7400-5 - PubMed
  7. Am J Pathol. 2000 Dec;157(6):2151-9 - PubMed
  8. J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9 - PubMed
  9. J Toxicol Environ Health Suppl. 1976;1:117-29 - PubMed
  10. Cell Death Differ. 2014 Feb;21(2):234-46 - PubMed
  11. J Cell Biol. 1994 May;125(3):681-93 - PubMed
  12. Oncogene. 2001 Apr 26;20(18):2325-32 - PubMed
  13. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7779-83 - PubMed
  14. Int Immunopharmacol. 2010 Jan;10 (1):140-5 - PubMed
  15. Oncogene. 2006 Nov 16;25(54):7148-58 - PubMed
  16. Genome Biol. 2011 Nov 11;12(11):233 - PubMed
  17. Dev Biol. 2007 Jun 1;306(1):193-207 - PubMed
  18. Cell Cycle. 2011 Mar 1;10(5):794-804 - PubMed
  19. J Clin Invest. 2015 Sep;125(9):3356-64 - PubMed
  20. Neurobiol Aging. 2013 Jun;34(6):1610-20 - PubMed
  21. Development. 2013 Jan 15;140(2):343-52 - PubMed
  22. Breast Cancer Res. 2015 Mar 14;17:38 - PubMed
  23. Nucleic Acids Res. 2017 Jan 4;45(D1):D730-D736 - PubMed
  24. J Leukoc Biol. 2013 Apr;93(4):633-7 - PubMed
  25. Oncogene. 2006 Sep 25;25(43):5885-97 - PubMed
  26. Nature. 2015 Sep 3;525(7567):114-8 - PubMed
  27. Physiology (Bethesda). 2016 Jul;31(4):250-7 - PubMed
  28. Mech Ageing Dev. 1983 Nov-Dec;23(3-4):259-64 - PubMed
  29. Oncogene. 2017 May 11;36(19):2693-2703 - PubMed
  30. Breast Cancer Res. 2008;10(1):203 - PubMed
  31. Breast Cancer (Auckl). 2015 Sep 15;9(Suppl 2):7-15 - PubMed
  32. PLoS One. 2015 Jun 15;10(6):e0129895 - PubMed
  33. Mol Cancer Res. 2011 Nov;9(11):1449-61 - PubMed
  34. Nature. 1994 Jun 23;369(6482):669-71 - PubMed
  35. Genesis. 2016 May;54(5):277-85 - PubMed
  36. Clin Exp Metastasis. 2005;22(1):47-59 - PubMed
  37. Dev Biol. 2014 Jun 15;390(2):181-90 - PubMed
  38. J Clin Invest. 2016 Oct 3;126(10 ):3942-3960 - PubMed
  39. Cancer Res. 1959 Jun;19(5):515-20 - PubMed
  40. Virchows Arch A Pathol Anat Histol. 1977 Mar 11;373(2):119-32 - PubMed
  41. Mol Biol Cell. 1998 Feb;9(2):421-35 - PubMed
  42. Cancer Res. 2007 Mar 15;67(6):2420-4 - PubMed
  43. Oncotarget. 2011 Dec;2(12):1043-54 - PubMed
  44. Immunol Cell Biol. 2012 Aug;90(7):722-32 - PubMed
  45. J Biol Chem. 1999 Jul 30;274(31):21491-4 - PubMed
  46. Cancer Res. 2004 Jan 1;64(1):169-79 - PubMed
  47. Nat Rev Drug Discov. 2013 May;12(5):347-57 - PubMed
  48. Proc Natl Acad Sci U S A. 1987 Mar;84(5):1299-303 - PubMed
  49. Clin Cancer Res. 2016 Apr 15;22(8):1865-74 - PubMed
  50. Am J Pathol. 1991 Sep;139(3):495-501 - PubMed
  51. Nucleic Acids Res. 2017 Jan 4;45(D1):D723-D729 - PubMed
  52. Cancer Res. 2003 May 15;63(10):2425-33 - PubMed
  53. Mech Ageing Dev. 2009 Jun;130(6):384-92 - PubMed
  54. Virchows Arch A Pathol Anat Histopathol. 1984;402(3):319-29 - PubMed
  55. Exp Gerontol. 2015 Jan;61:84-91 - PubMed
  56. Endocr Rev. 1984 Fall;5(4):467-97 - PubMed
  57. Cancer Res. 2006 Jan 15;66(2):1123-31 - PubMed
  58. Mol Cell Biol. 2001 Mar;21(5):1540-51 - PubMed
  59. Nat Immunol. 2007 Feb;8(2):191-7 - PubMed
  60. Toxicol Pathol. 2015 Aug;43(6):883-9 - PubMed
  61. Science. 2011 Mar 25;331(6024):1565-70 - PubMed
  62. Nat Rev Cancer. 2012 May 04;12(6):381-5 - PubMed
  63. Nucleic Acids Res. 1997 Nov 1;25(21):4323-30 - PubMed
  64. Biochem Soc Symp. 2003;(70):253-62 - PubMed
  65. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15807-12 - PubMed
  66. Cancer Res. 2005 Feb 1;65(3):879-86 - PubMed
  67. Vet Pathol. 2012 Jan;49(1):85-105 - PubMed
  68. Cell Growth Differ. 1998 Mar;9(3):229-38 - PubMed
  69. J Immunol. 2013 Dec 15;191(12):5793-6 - PubMed
  70. Breast Cancer Res. 2005;7(6):R881-9 - PubMed
  71. Am J Pathol. 2011 Dec;179(6):3075-85 - PubMed
  72. Cancer Res. 2012 Apr 15;72(8):2089-99 - PubMed
  73. Semin Cell Dev Biol. 2009 Apr;20(2):126-37 - PubMed
  74. J Ultrastruct Res. 1967 Nov;21(1):9-25 - PubMed
  75. Am J Pathol. 2002 Jul;161(1):337-44 - PubMed
  76. Int Immunol. 1996 Apr;8(4):509-18 - PubMed
  77. Exp Gerontol. 2010 Feb;45(2):163-9 - PubMed
  78. Clin Exp Immunol. 2017 Jan;187(1):53-63 - PubMed
  79. Exp Gerontol. 1971 Feb 1;6(1):49-56 - PubMed
  80. J Mammary Gland Biol Neoplasia. 1999 Jan;4(1):105-22 - PubMed
  81. Trends Cancer. 2016 Nov;2(11):676-687 - PubMed
  82. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7849-53 - PubMed
  83. Nat Immunol. 2011 Jun;12(6):478-84 - PubMed
  84. Clin Exp Immunol. 2008 Jun;152(3):448-55 - PubMed
  85. Biochim Biophys Acta. 2010 Jan;1803(1):55-71 - PubMed
  86. Aging Cell. 2017 Jun;16(3):480-487 - PubMed
  87. Endocr Relat Cancer. 2014 May 06;21(3):R195-208 - PubMed
  88. Cell Mol Immunol. 2016 Sep;13(5):628-39 - PubMed
  89. Bull World Health Organ. 1970;43(2):209-21 - PubMed
  90. Mol Cancer Ther. 2004 Aug;3(8):941-53 - PubMed
  91. Br J Cancer. 2005 Jan 17;92(1):167-75 - PubMed
  92. Physiol Genomics. 2008 Aug 15;34(3):304-14 - PubMed
  93. Mol Endocrinol. 1988 Nov;2(11):1027-32 - PubMed
  94. J Immunol. 2005 Oct 1;175(7):4583-92 - PubMed
  95. Mol Endocrinol. 1988 Feb;2(2):143-7 - PubMed
  96. EMBO J. 1988 Jan;7(1):169-75 - PubMed
  97. Curr Pharm Des. 2013;19(9):1675-9 - PubMed
  98. Nat Rev Cancer. 2006 Apr;6(4):281-91 - PubMed
  99. Neoplasia. 2012 Aug;14(8):678-89 - PubMed
  100. Fed Proc. 1975 Jan;34(1):64-7 - PubMed
  101. Sci Adv. 2016 Mar 18;2(3):e1501473 - PubMed
  102. Nucleic Acids Res. 2015 Jan;43(Database issue):D818-24 - PubMed
  103. Am J Pathol. 2004 Aug;165(2):695-705 - PubMed
  104. Front Immunol. 2013 Oct 07;4:316 - PubMed
  105. Int Immunol. 2005 Apr;17(4):383-90 - PubMed
  106. Breast Cancer Res. 2017 Sep 2;19(1):102 - PubMed
  107. Biosci Rep. 2012 Apr 1;32(2):113-30 - PubMed
  108. Cancer Res. 2007 Jul 1;67(13):6442-50 - PubMed
  109. J Exp Med. 2012 Mar 12;209(3):495-506 - PubMed
  110. Am J Pathol. 2005 Aug;167(2):585-97 - PubMed
  111. Cell. 1996 Feb 9;84(3):443-50 - PubMed
  112. Eur J Immunol. 2016 Dec;46(12 ):2835-2841 - PubMed
  113. Mol Cancer Res. 2004 Aug;2(8):453-63 - PubMed
  114. Breast Cancer Res. 2014 Mar 28;16(2):R31 - PubMed
  115. Oncogene. 1993 Jul;8(7):1965-71 - PubMed
  116. Cancer Res. 1991 Jul 15;51(14):3762-7 - PubMed
  117. Vet Pathol. 2009 Jul;46(4):736-45 - PubMed
  118. Biol Reprod. 1982 Sep;27(2):327-39 - PubMed
  119. J Clin Invest. 2011 Jan;121(1):226-37 - PubMed
  120. Oncogene. 2014 Nov 27;33(48):5511-5522 - PubMed
  121. Transgenic Res. 2007 Apr;16(2):193-201 - PubMed
  122. J Pathol. 2015 May;236(1):90-102 - PubMed
  123. J Cell Biol. 2001 Apr 30;153(3):555-68 - PubMed
  124. Nat Rev Cancer. 2004 Sep;4(9):665-76 - PubMed
  125. Dev Biol. 2012 Dec 1;372(1):28-44 - PubMed
  126. J Exp Med. 2013 Oct 21;210(11):2435-66 - PubMed
  127. Neoplasia. 2010 Nov;12(11):899-905 - PubMed
  128. J Immunol. 2017 Jul 1;199(1):138-148 - PubMed
  129. Aging Cell. 2009 Jun;8(3):277-87 - PubMed
  130. Nat Cell Biol. 2008 Jun;10(6):716-22 - PubMed
  131. Aging Cell. 2013 Oct;12 (5):794-801 - PubMed
  132. Cold Spring Harb Perspect Biol. 2011 Sep 01;3(9):a009670 - PubMed
  133. Dis Model Mech. 2011 May;4(3):347-58 - PubMed
  134. Proc Natl Acad Sci U S A. 1968 Sep;61(1):53-60 - PubMed
  135. Blood. 1993 Nov 1;82(9):2767-73 - PubMed
  136. Mol Cell Biol. 2000 Jun;20(12):4462-73 - PubMed
  137. PLoS Biol. 2004 Feb;2(2):E22 - PubMed
  138. Trends Endocrinol Metab. 2017 Mar;28(3):199-212 - PubMed
  139. Cancer. 2004 Jul 15;101(2):353-62 - PubMed
  140. J Immunol. 2002 Sep 1;169(5):2756-61 - PubMed
  141. Clin Immunol Immunopathol. 1991 May;59(2):301-13 - PubMed
  142. Mech Ageing Dev. 2007 Nov-Dec;128(11-12):672-80 - PubMed
  143. Transgenic Res. 2001 Dec;10(6):545-53 - PubMed
  144. J Immunol. 2006 Dec 15;177(12):8348-55 - PubMed
  145. J Mammary Gland Biol Neoplasia. 1999 Jan;4(1):35-52 - PubMed
  146. Toxicol Pathol. 1995 May-Jun;23(3):241-7 - PubMed
  147. Cell. 2013 Apr 11;153(2):449-60 - PubMed
  148. Cancer Res. 1996 Apr 15;56(8):1775-85 - PubMed
  149. Mech Ageing Dev. 2011 Apr;132(4):187-94 - PubMed
  150. J Biol Chem. 2001 May 25;276(21):18563-9 - PubMed
  151. Nat Immunol. 2004 Feb;5(2):133-9 - PubMed
  152. Cell Rep. 2016 Sep 27;17 (1):249-260 - PubMed
  153. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16387-92 - PubMed
  154. Genes Dev. 2011 Nov 1;25(21):2227-41 - PubMed
  155. J Immunol. 2013 Mar 1;190(5):2424-36 - PubMed
  156. Trends Immunol. 2016 Dec;37(12 ):855-865 - PubMed
  157. Virchows Arch A Pathol Anat Histol. 1976 Dec 27;372(3):205-26 - PubMed
  158. Cancer Cell. 2006 Nov;10(5):437-49 - PubMed
  159. Pathobiol Aging Age Relat Dis. 2011;1:null - PubMed
  160. Curr Opin Immunol. 2014 Apr;27:16-25 - PubMed
  161. Cell. 1984 Oct;38(3):627-37 - PubMed
  162. Cell. 1996 Feb 9;84(3):431-42 - PubMed
  163. Breast Cancer Res. 2012 Jan 20;14(1):R16 - PubMed
  164. J Immunol. 2015 Jun 15;194(12):5725-35 - PubMed
  165. Oncogene. 2008 May 22;27(23):3274-81 - PubMed
  166. J Immunol. 2000 Oct 1;165(7):3571-7 - PubMed
  167. Semin Cancer Biol. 1996 Oct;7(5):269-78 - PubMed
  168. Longev Healthspan. 2013 May 02;2(1):8 - PubMed
  169. JAKSTAT. 2012 Jul 1;1(3):197-9 - PubMed
  170. Trends Mol Med. 2014 Mar;20(3):143-53 - PubMed
  171. Nat Genet. 1999 May;22(1):37-43 - PubMed
  172. J Cell Sci. 1988 May;90 ( Pt 1):173-83 - PubMed
  173. Mol Cell Biol. 2001 Mar;21(6):2203-12 - PubMed
  174. Nat Rev Mol Cell Biol. 2005 Oct;6(10):801-11 - PubMed
  175. J Natl Cancer Inst. 1975 May;54(5):1215-21 - PubMed
  176. J Cell Biol. 1995 Oct;131(2):275-8 - PubMed
  177. J Immunol. 2011 Jan 15;186(2):697-707 - PubMed
  178. PLoS One. 2015 Mar 25;10(3):e0120107 - PubMed

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