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Miller C, Emanuelli M, Fink E, et al. FIV vaccine with receptor epitopes results in neutralizing antibodies but does not confer resistance to challenge. NPJ Vaccines. 2018;3:16doi: 10.1038/s41541-018-0051-y.
Miller, C., Emanuelli, M., Fink, E., Musselman, E., Mackie, R., Troyer, R., Elder, J., & VandeWoude, S. (2018). FIV vaccine with receptor epitopes results in neutralizing antibodies but does not confer resistance to challenge. NPJ vaccines, 316. https://doi.org/10.1038/s41541-018-0051-y
Miller, Craig, et al. "FIV vaccine with receptor epitopes results in neutralizing antibodies but does not confer resistance to challenge." NPJ vaccines vol. 3 (2018): 16. doi: https://doi.org/10.1038/s41541-018-0051-y
Miller C, Emanuelli M, Fink E, Musselman E, Mackie R, Troyer R, Elder J, VandeWoude S. FIV vaccine with receptor epitopes results in neutralizing antibodies but does not confer resistance to challenge. NPJ Vaccines. 2018 Apr 30;3:16. doi: 10.1038/s41541-018-0051-y. eCollection 2018. PMID: 29736270; PMCID: PMC5928050.
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NPJ Vaccines. 2018 Apr 30;3:16. doi: 10.1038/s41541-018-0051-y. eCollection 2018.

FIV vaccine with receptor epitopes results in neutralizing antibodies but does not confer resistance to challenge.

NPJ vaccines

Craig Miller, Mauren Emanuelli, Elizabeth Fink, Esther Musselman, Ryan Mackie, Ryan Troyer, John Elder, Sue VandeWoude

Affiliations

  1. 1Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO USA.
  2. 2Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA USA.

PMID: 29736270 PMCID: PMC5928050 DOI: 10.1038/s41541-018-0051-y

Abstract

Feline immunodeficiency virus (FIV) is the feline analogue to human immunodeficiency virus (HIV) and utilizes parallel modes of receptor-mediated entry. The FIV surface glycoprotein (SU) is an important target for induction of neutralizing antibodies, and autoantibodies to the FIV binding receptor (CD134) block infection ex vivo; thus highlighting the potential for immunotherapies which utilize anti-receptor antibodies to block viral infection. To determine whether vaccination with CD134-SU complexes could induce protection against FIV infection, cats (

Conflict of interest statement

The authors declare no competing interests.

References

  1. Lancet. 1988 Apr 9;1(8589):790-4 - PubMed
  2. J Feline Med Surg. 2005 Feb;7(1):65-70 - PubMed
  3. AIDS Res Hum Retroviruses. 1995 Aug;11(8):963-70 - PubMed
  4. J Virol. 1999 Apr;73(4):2596-603 - PubMed
  5. J Gen Virol. 2004 Jul;85(Pt 7):1955-63 - PubMed
  6. J Virol. 2003 Oct;77(19):10557-65 - PubMed
  7. Viruses. 2011 Nov;3(11):2192-213 - PubMed
  8. AIDS. 2007 Mar 12;21(5):547-63 - PubMed
  9. J Virol. 1991 Aug;65(8):4169-76 - PubMed
  10. J Biol Chem. 2002 Sep 20;277(38):35019-24 - PubMed
  11. Vaccine. 2009 Jan 22;27(4):505-12 - PubMed
  12. J Immunol. 2007 Oct 1;179(7):4357-66 - PubMed
  13. AIDS. 2001 Jul 6;15(10):1225-37 - PubMed
  14. Vet Immunol Immunopathol. 1999 Nov 30;71(3-4):291-305 - PubMed
  15. Comp Immunol Microbiol Infect Dis. 2013 Dec;36(6):549-57 - PubMed
  16. J Transl Med. 2006 Oct 04;4:40 - PubMed
  17. Vet Immunol Immunopathol. 2008 May 15;123(1-2):3-13 - PubMed
  18. Vaccine. 2006 Nov 30;24(49-50):7095-108 - PubMed
  19. J Immunol. 1999 Dec 15;163(12):6448-54 - PubMed
  20. Antiviral Res. 1989 Apr;11(3):137-46 - PubMed
  21. J Virol. 2005 Jun;79(11):6957-68 - PubMed
  22. AIDS. 1990 Oct;4(10):961-5 - PubMed
  23. Curr HIV Res. 2010 Jan;8(1):73-80 - PubMed
  24. Clin Vaccine Immunol. 2006 Jan;13(1):106-15 - PubMed
  25. J Virol. 2008 Aug;82(16):7953-63 - PubMed
  26. J Virol. 2004 Sep;78(17):9132-43 - PubMed
  27. J Virol. 1994 Dec;68(12):8374-9 - PubMed
  28. J Virol. 1997 Dec;71(12):9640-9 - PubMed
  29. PLoS One. 2011;6(8):e24020 - PubMed
  30. Vet Rec. 2006 Apr 22;158(16):561-2 - PubMed
  31. PLoS One. 2016 Jan 04;11(1):e0145637 - PubMed
  32. J Virol. 1995 Jun;69(6):3704-11 - PubMed
  33. J Exp Med. 1995 Dec 1;182(6):1727-37 - PubMed
  34. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19980-5 - PubMed
  35. J Virol. 2006 Mar;80(6):3088-91 - PubMed
  36. J Exp Med. 1991 May 1;173(5):1151-8 - PubMed
  37. Annu Rev Immunol. 1999;17:657-700 - PubMed
  38. Vaccine. 2016 Sep 7;34(39):4752-4758 - PubMed
  39. Clin Vaccine Immunol. 2011 Mar;18(3):387-92 - PubMed
  40. Vet Immunol Immunopathol. 2002 Dec;90(3-4):113-32 - PubMed
  41. Viruses. 2011 Oct;3(10 ):1870-90 - PubMed
  42. J Gen Virol. 1999 Mar;80 ( Pt 3):761-5 - PubMed
  43. Am J Vet Res. 1995 Jun;56(6):764-8 - PubMed
  44. J Gen Virol. 2002 Oct;83(Pt 10):2515-21 - PubMed
  45. Vaccine. 1997 Aug;15(11):1183-93 - PubMed
  46. Curr HIV Res. 2003 Jan;1(1):15-29 - PubMed
  47. Vet Immunol Immunopathol. 2001 May 10;79(1-2):53-67 - PubMed
  48. Vaccine. 2014 Feb 3;32(6):746-54 - PubMed
  49. Virology. 2013 Feb 20;436(2):284-94 - PubMed
  50. J Virol. 2008 Sep;82(18):9134-42 - PubMed
  51. AIDS. 2001 Feb;15 Suppl 1:S34-5 - PubMed
  52. J Virol. 1990 Jan;64(1):113-9 - PubMed
  53. Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13044-9 - PubMed
  54. Virology. 2008 Jul 20;377(1):63-70 - PubMed
  55. AIDS. 1999 Oct 1;13(14):1841-9 - PubMed
  56. Curr Opin Virol. 2013 Dec;3(6):670-5 - PubMed
  57. J Virol. 2001 May;75(10):4528-39 - PubMed
  58. Vet Immunol Immunopathol. 1992 Dec;35(1-2):191-7 - PubMed
  59. Vet Immunol Immunopathol. 2008 May 15;123(1-2):65-80 - PubMed
  60. Clin Exp Immunol. 1985 Jul;61(1):143-51 - PubMed
  61. Nature. 2002 Dec 12;420(6916):678-82 - PubMed
  62. Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13026-31 - PubMed
  63. J Virol. 1995 Oct;69(10):6054-62 - PubMed
  64. J Virol. 1993 May;67(5):2699-706 - PubMed
  65. J Immunol Methods. 2013 Oct 31;396(1-2):74-86 - PubMed
  66. J Leukoc Biol. 1997 Jul;62(1):67-71 - PubMed
  67. Vaccine. 2015 Feb 18;33(8):977-84 - PubMed
  68. New Microbiol. 2013 Apr;36(2):145-51 - PubMed
  69. J Infect Dis. 1999 May;179 Suppl 3:S457-60 - PubMed
  70. Annu Rev Biochem. 1988;57:321-47 - PubMed
  71. J Virol. 2003 Mar;77(5):2859-65 - PubMed
  72. Nat Struct Mol Biol. 2005 Jan;12(1):60-6 - PubMed
  73. Immunol Lett. 1989 Aug;22(2):135-45 - PubMed
  74. J Virol. 1990 Oct;64(10):5223-5 - PubMed
  75. J Virol. 2013 Jul;87(14):7940-51 - PubMed
  76. AIDS Res Hum Retroviruses. 1991 Jul;7(7):579-85 - PubMed
  77. Curr HIV Res. 2010 Jan;8(1):14-25 - PubMed
  78. J Virol. 2002 Jul;76(14):6882-92 - PubMed
  79. J Med Primatol. 2001 Oct;30(5):254-9 - PubMed
  80. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6913-8 - PubMed
  81. Springer Semin Immunopathol. 1997;18(3):371-90 - PubMed
  82. J Virol. 1993 Sep;67(9):5175-86 - PubMed
  83. Retrovirology. 2011 Mar 14;8:16 - PubMed
  84. Clin Microbiol Rev. 2006 Oct;19(4):728-62 - PubMed
  85. J Virol. 1990 Nov;64(11):5301-5 - PubMed
  86. J Immunol. 2008 Jan 1;180(1):350-60 - PubMed

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