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Leyens L, Horgan D, Lal JA, et al. Working towards personalization in medicine: main obstacles to reaching this vision from today's perspective. Per Med. 2014;11(7):641-649doi: 10.2217/pme.14.55.
Leyens, L., Horgan, D., Lal, J. A., Steinhausen, K., Satyamoorthy, K., & Brand, A. (2014). Working towards personalization in medicine: main obstacles to reaching this vision from today's perspective. Personalized medicine, 11(7), 641-649. https://doi.org/10.2217/pme.14.55
Leyens, Lada, et al. "Working towards personalization in medicine: main obstacles to reaching this vision from today's perspective." Personalized medicine vol. 11,7 (2014): 641-649. doi: https://doi.org/10.2217/pme.14.55
Leyens L, Horgan D, Lal JA, Steinhausen K, Satyamoorthy K, Brand A. Working towards personalization in medicine: main obstacles to reaching this vision from today's perspective. Per Med. 2014 Sep;11(7):641-649. doi: 10.2217/pme.14.55. PMID: 29764055.
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Per Med. 2014 Sep;11(7):641-649. doi: 10.2217/pme.14.55.

Working towards personalization in medicine: main obstacles to reaching this vision from today's perspective.

Personalized medicine

Lada Leyens, Denis Horgan, Jonathan A Lal, Kirsten Steinhausen, Kapaettu Satyamoorthy, Angela Brand

Affiliations

  1. Institute for Public Health Genomics, Department of Genetics & Cell Biology, School for Oncology & Developmental Biology (GROW), Faculty of Health Medicine & Life Sciences, Maastricht University, Maastricht, The Netherlands.
  2. European Alliance for Personalized Medicine, Brussels, Belgium.
  3. European Science Foundation & Furtwangen University, Furtwangen, Germany.
  4. Manipal Life Sciences Centre, Manipal University, Manipal, India.

PMID: 29764055 DOI: 10.2217/pme.14.55

Abstract

Rapid advances in 'omics' sciences and technologies have elevated the relevance of personalized medicine. This article reviews the current advances in the application of personalized medicine, outlines and summarizes the key areas that still need to be addressed and gives recommendations in this direction. Eighteen relevant high-level reports on personalized medicine were reviewed in order to identify the gaps and needs that are present for the implementation of personalized medicine. We identify 12 key areas that represent the main obstacles on the road towards the personalization of medicine and divide these 12 key areas into four domains, namely: scientific research and stakeholder collaboration; translational tools; regulations and systematic early dialog with regulators; and uptake into healthcare systems. All of the evaluated reports agree on the imperative need for intensive collaboration among all stakeholders with early active participation and changes in the current healthcare infrastructure.

Keywords: P4 health; cost–benefit analysis; genomics; healthcare systems; personalized medicine; public health genomics; stakeholder collaboration; systematic early dialog; technology transfer; translational research

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