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Lashkari M, Noori A, Oveisi S, et al. Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study. Electron Physician. 2018;10(3):6500-6505doi: 10.19082/6500.
Lashkari, M., Noori, A., Oveisi, S., & Kheirkhah, M. (2018). Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study. Electronic physician, 10(3), 6500-6505. https://doi.org/10.19082/6500
Lashkari, Mahin, et al. "Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study." Electronic physician vol. 10,3 (2018): 6500-6505. doi: https://doi.org/10.19082/6500
Lashkari M, Noori A, Oveisi S, Kheirkhah M. Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study. Electron Physician. 2018 Mar 25;10(3):6500-6505. doi: 10.19082/6500. eCollection 2018 Mar. PMID: 29765575; PMCID: PMC5942571.
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Electron Physician. 2018 Mar 25;10(3):6500-6505. doi: 10.19082/6500. eCollection 2018 Mar.

Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study.

Electronic physician

Mahin Lashkari, Akram Noori, Sonia Oveisi, Mohammadreza Kheirkhah

Affiliations

  1. M.D., Rheumatologist, Assistant Professor, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
  2. M.D., MPH, Ph.D. of Maternal and Child Health, Associate Professor, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
  3. M.D., Pathologist, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

PMID: 29765575 PMCID: PMC5942571 DOI: 10.19082/6500

Abstract

BACKGROUND: It is supposed that hypoandrogenism may be involved in the pathogenesis of rheumatoid arthritis (RA). Testosterone and dehydroepiandrosterone sulfate (DHEAs) levels decrease in body fluids of patients with RA.

OBJECTIVE: The aim of this study was to determine the association of serum testosterone and DHEAs with RA.

METHODS: This case-control study was conducted on 59 patients with RA and 61 healthy gender- and age-matched controls at Qazvin University of Medical Sciences, Qazvin, Iran, in 2014. Serum free testosterone and DHEAs levels were measured and compared between two groups. Serum testosterone levels lower than 0.029 ng/ml in females and 2.49 ng/ml in males were considered as abnormal. DHEAs levels lower than 18.9 μg/dl in females and 88.9 μg/dl in males were considered as abnormal. Data were analyzed using independent sample T-test, Chi-square test, and logistic regression analysis by SPSS software, version 19.

RESULTS: The mean testosterone level in females of the control group was significantly higher than females in the case group. The mean DHEAs in the control group was significantly higher than the case group. Abnormal testosterone and DHEAs level in the case group was significantly higher than the control group. Logistic regression analysis showed independent association only between DHEAs levels and RA, after adjusting for age and gender (OR: 0.966, 95% CI: 0.953-0.979; p<0.001).

CONCLUSION: With regard to the results, abnormal testosterone and DHEAs level in patients with RA was significantly higher than the control group. This shows the anti-inflammatory effects of gonadal and adrenal androgens in RA.

Keywords: Androgens; Cellular immunity; Dehydroepiandrosterone sulfate; Humoral immunity; Rheumatoid arthritis

Conflict of interest statement

Conflict of Interest: There is no conflict of interest to be declared.

References

  1. Rheum Dis Clin North Am. 2000 Nov;26(4):881-95 - PubMed
  2. Clin Exp Rheumatol. 1993 Nov-Dec;11(6):597-601 - PubMed
  3. J Clin Endocrinol Metab. 2004 Jul;89(7):3313-8 - PubMed
  4. Ann Rheum Dis. 2010 Sep;69(9):1580-8 - PubMed
  5. Cell Immunol. 2008 Mar-Apr;252(1-2):57-67 - PubMed
  6. Curr Rheumatol Rep. 2011 Oct;13(5):421-30 - PubMed
  7. Ann N Y Acad Sci. 2006 Jun;1069:77-97 - PubMed
  8. Drugs. 2014 Jul;74(11):1195-207 - PubMed
  9. J Rheumatol. 2009 May;36(5):887-92 - PubMed
  10. Biol Sex Differ. 2011 Jan 04;2(1):1 - PubMed
  11. Endocr Regul. 2009 Apr;43(2):65-73 - PubMed
  12. Arthritis Res Ther. 2009;11(2):218 - PubMed
  13. Ann Rheum Dis. 2014 Mar;73(3):573-9 - PubMed
  14. Caspian J Intern Med. 2011 Winter;2(1):161-70 - PubMed
  15. J Rheumatol. 2010 Jan;37(1):32-7 - PubMed
  16. Autoimmune Dis. 2013;2013:593493 - PubMed
  17. Arthritis Res. 2001;3(3):183-8 - PubMed
  18. Br J Rheumatol. 1996 Jun;35(6):568-73 - PubMed
  19. Immunogenetics. 2011 Aug;63(8):459-66 - PubMed
  20. Arch Med Sci. 2011 Apr;7(2):189-94 - PubMed
  21. Ann N Y Acad Sci. 2006 Jun;1069:391-400 - PubMed
  22. Curr Med Chem. 2010;17(11):1039-47 - PubMed
  23. Arthritis Rheum. 1991 Jan;34(1):1-5 - PubMed
  24. J Steroid Biochem Mol Biol. 2010 May 31;120(2-3):105-15 - PubMed
  25. Clin Immunol. 2013 Nov;149(2):251-64 - PubMed
  26. Hand Clin. 2011 Feb;27(1):11-20 - PubMed
  27. Rheum Dis Clin North Am. 2000 Nov;26(4):825-39 - PubMed
  28. Swiss Med Wkly. 2013 Sep 19;143:w13865 - PubMed
  29. Aging Male. 2015 Mar;18(1):5-15 - PubMed
  30. Ann N Y Acad Sci. 2002 Jun;966:158-65 - PubMed
  31. Ann Rheum Dis. 2000 Sep;59(9):657-61 - PubMed
  32. Br J Rheumatol. 1988 Dec;27(6):440-4 - PubMed
  33. Drug Des Devel Ther. 2013 Aug 22;7:849-60 - PubMed
  34. Dis Markers. 2013;35(6):727-34 - PubMed
  35. Arthritis Res Ther. 2009;11(3):R97 - PubMed

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