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Ytrehus K, Hulot JS, Perrino C, et al. Perivascular fibrosis and the microvasculature of the heart. Still hidden secrets of pathophysiology?. Vascul Pharmacol. 2018;doi: 10.1016/j.vph.2018.04.007.
Ytrehus, K., Hulot, J. S., Perrino, C., Schiattarella, G. G., & Madonna, R. (2018). Perivascular fibrosis and the microvasculature of the heart. Still hidden secrets of pathophysiology?. Vascular pharmacology, . https://doi.org/10.1016/j.vph.2018.04.007
Ytrehus, Kirsti, et al. "Perivascular fibrosis and the microvasculature of the heart. Still hidden secrets of pathophysiology?." Vascular pharmacology vol. (2018). doi: https://doi.org/10.1016/j.vph.2018.04.007
Ytrehus K, Hulot JS, Perrino C, Schiattarella GG, Madonna R. Perivascular fibrosis and the microvasculature of the heart. Still hidden secrets of pathophysiology?. Vascul Pharmacol. 2018 Apr 27; doi: 10.1016/j.vph.2018.04.007. Epub 2018 Apr 27. PMID: 29709645.
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Vascul Pharmacol. 2018 Apr 27; doi: 10.1016/j.vph.2018.04.007. Epub 2018 Apr 27.

Perivascular fibrosis and the microvasculature of the heart. Still hidden secrets of pathophysiology?.

Vascular pharmacology

Kirsti Ytrehus, Jean-Sébastien Hulot, Cinzia Perrino, Gabriele Giacomo Schiattarella, Rosalinda Madonna

Affiliations

  1. Cardiovascular Research Group, Dept of Medical Biology, UiT The Arctic University of Norway, Norway. Electronic address: [email protected].
  2. INSERM, U970, Paris Cardiovascular Research Center (PARCC), Université Paris Descartes, Paris, France.
  3. Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
  4. Center of Aging Sciences and Translational Medicine - CESI-MeT, Institute of Cardiology, "G. d'Annunzio" University, Chieti, Italy; The Texas Heart Institute and Center for Cardiovascular Biology and Atherosclerosis Research, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, United States.

PMID: 29709645 DOI: 10.1016/j.vph.2018.04.007

Abstract

Perivascular fibrosis, the deposition of connective tissue around the vessels, has been demonstrated crucially involved in the development of cardiac dysfunction. Although cardiac fibrosis has been shown to be reversible under certain experimental conditions, effective anti-fibrotic therapies remain largely elusive. Therefore, perivascular fibrosis currently represents a major therapeutic target for cardiovascular diseases. The main topic of this review will be to address the mechanisms underlying perivascular fibrosis of the vasculature within the myocardium, with a special focus on perivascular fibrosis of small vessels, microvascular dysfunction and disease.

Copyright © 2018. Published by Elsevier Inc.

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