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Carmody T, Greer TL, Walker R, et al. A Complier Average Causal Effect Analysis of the Stimulant Reduction Intervention using Dosed Exercise Study. Contemp Clin Trials Commun. 2018;10:1-8doi: 10.1016/j.conctc.2018.02.001.
Carmody, T., Greer, T. L., Walker, R., Rethorst, C. D., & Trivedi, M. H. (2018). A Complier Average Causal Effect Analysis of the Stimulant Reduction Intervention using Dosed Exercise Study. Contemporary clinical trials communications, 101-8. https://doi.org/10.1016/j.conctc.2018.02.001
Carmody, Thomas, et al. "A Complier Average Causal Effect Analysis of the Stimulant Reduction Intervention using Dosed Exercise Study." Contemporary clinical trials communications vol. 10 (2018): 1-8. doi: https://doi.org/10.1016/j.conctc.2018.02.001
Carmody T, Greer TL, Walker R, Rethorst CD, Trivedi MH. A Complier Average Causal Effect Analysis of the Stimulant Reduction Intervention using Dosed Exercise Study. Contemp Clin Trials Commun. 2018 Jun;10:1-8. doi: 10.1016/j.conctc.2018.02.001. PMID: 29682627; PMCID: PMC5898532.
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Contemp Clin Trials Commun. 2018 Jun;10:1-8. doi: 10.1016/j.conctc.2018.02.001.

A Complier Average Causal Effect Analysis of the Stimulant Reduction Intervention using Dosed Exercise Study.

Contemporary clinical trials communications

Thomas Carmody, Tracy L Greer, Robrina Walker, Chad D Rethorst, Madhukar H Trivedi

Affiliations

  1. University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.

PMID: 29682627 PMCID: PMC5898532 DOI: 10.1016/j.conctc.2018.02.001

Abstract

OBJECTIVE: Exercise is a promising treatment for substance use disorders, yet an intention-to-treat analysis of a large, multi-site study found no reduction in stimulant use for exercise versus health education. Exercise adherence was sub-optimal; therefore, secondary post-hoc complier average causal effects (CACE) analysis was conducted to determine the potential effectiveness of adequately dosed exercise.

METHOD: The STimulant use Reduction Intervention using Dosed Exercise study was a randomized controlled trial comparing a 12 kcal/kg/week (KKW) exercise dose versus a health education control conducted at nine residential substance use treatment settings across the U.S. that are affiliated with the National Drug Abuse Treatment Clinical Trials Network. Participants were sedentary but medically approved for exercise, used stimulants within 30 days prior to study entry, and received a DSM-IV stimulant abuse or dependence diagnosis within the past year. A CACE analysis adjusted to include only participants with a minimum threshold of adherence (at least 8.3 KKW) and using a negative-binomial hurdle model focused on 218 participants who were 36.2% female, mean age 39.4 years (

RESULTS: The CACE-adjusted analysis found a significantly lower probability of relapse to stimulant use in the exercise group versus the health education group (41.0% vs. 55.7%,

CONCLUSIONS: The CACE adjustment revealed significant, positive effects for exercise. Further research is warranted to develop strategies for exercise adherence that can ensure achievement of an exercise dose sufficient to produce a significant treatment effect.

Keywords: Clinical Trials Network; complier average causal effects; exercise intervention; health education; stimulant abuse or dependence

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