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Bontidean I, Kumar A, Csöregi E, et al. Highly Sensitive Novel Biosensor Based on an Immobilized lac Repressor. Angew Chem Int Ed Engl. 2001;40(14):2676-2678doi: 10.1002/1521-3773(20010716)40:14<2676::AID-ANIE2676>3.0.CO;2-5.
Bontidean, I., Kumar, A., Csöregi, E., Galaev, I. Y., & Mattiasson, B. (2001). Highly Sensitive Novel Biosensor Based on an Immobilized lac Repressor. Angewandte Chemie (International ed. in English), 40(14), 2676-2678. https://doi.org/10.1002/1521-3773(20010716)40:14<2676::AID-ANIE2676>3.0.CO;2-5
Bontidean, Ibolya, et al. "Highly Sensitive Novel Biosensor Based on an Immobilized lac Repressor." Angewandte Chemie (International ed. in English) vol. 40,14 (2001): 2676-2678. doi: https://doi.org/10.1002/1521-3773(20010716)40:14<2676::AID-ANIE2676>3.0.CO;2-5
Bontidean I, Kumar A, Csöregi E, Galaev IY, Mattiasson B. Highly Sensitive Novel Biosensor Based on an Immobilized lac Repressor. Angew Chem Int Ed Engl. 2001 Jul 16;40(14):2676-2678. doi: 10.1002/1521-3773(20010716)40:14<2676::AID-ANIE2676>3.0.CO;2-5. PMID: 29712325.
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Angew Chem Int Ed Engl. 2001 Jul 16;40(14):2676-2678. doi: 10.1002/1521-3773(20010716)40:14<2676::AID-ANIE2676>3.0.CO;2-5.

Highly Sensitive Novel Biosensor Based on an Immobilized lac Repressor.

Angewandte Chemie (International ed. in English)

Ibolya Bontidean, Ashok Kumar, Elisabeth Csöregi, Igor Yu Galaev, Bo Mattiasson

Affiliations

  1. Department of Biotechnology Center for Chemistry and Chemical Engineering Lund University 22100, Lund (Sweden) Fax: (+46)?46-222-4713.

PMID: 29712325 DOI: 10.1002/1521-3773(20010716)40:14<2676::AID-ANIE2676>3.0.CO;2-5

Abstract

Sensitive repressors: The conformational change that occurs in the lac repressor protein when it binds to an inducer molecule has been used to develop a biosensor that permits the detection of the corresponding operator sequence or specific inducer molecules. A capacitive signal transducer was used to translate the conformational change of the lac repressor protein, covalently immobilized on a gold electrode (see schematic representation, A=bound inducer molecule or DNA), into a measurable signal.

© 2001 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.

Keywords: DNA recognition; biosensors; capacitance measurement; proteins

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