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Vagapova ER, Spirin PV, Lebedev TD, et al. The Role of TAL1 in Hematopoiesis and Leukemogenesis. Acta Naturae. 2018;10(1):15-23
Vagapova, E. R., Spirin, P. V., Lebedev, T. D., & Prassolov, V. S. (2018). The Role of TAL1 in Hematopoiesis and Leukemogenesis. Acta naturae, 10(1), 15-23.
Vagapova, E R, et al. "The Role of TAL1 in Hematopoiesis and Leukemogenesis." Acta naturae vol. 10,1 (2018): 15-23.
Vagapova ER, Spirin PV, Lebedev TD, Prassolov VS. The Role of TAL1 in Hematopoiesis and Leukemogenesis. Acta Naturae. 2018 Jan-Mar;10(1):15-23. PMID: 29713515; PMCID: PMC5916730.
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Acta Naturae. 2018 Jan-Mar;10(1):15-23.

The Role of TAL1 in Hematopoiesis and Leukemogenesis.

Acta naturae

E R Vagapova, P V Spirin, T D Lebedev, V S Prassolov

Affiliations

  1. The Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova Str. 32, Moscow,119991, Russia.

PMID: 29713515 PMCID: PMC5916730

Abstract

TAL1 (SCL/TAL1, T-cell acute leukemia protein 1) is a transcription factor that is involved in the process of hematopoiesis and leukemogenesis. It participates in blood cell formation, forms mesoderm in early embryogenesis, and regulates hematopoiesis in adult organisms. TAL1 is essential in maintaining the multipotency of hematopoietic stem cells (HSC) and keeping them in quiescence (stage G0). TAL1 forms complexes with various transcription factors, regulating hematopoiesis (E2A/HEB, GATA1-3, LMO1-2, Ldb1, ETO

Keywords: T-cell acute lymphoblastic leukemia; acute myeloid leukemia; hematopoiesis; receptor tyrosine kinase C-KIT

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