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Nanashima A, Tominaga T, Sumida Y, et al. Indocyanine green identification for tumor infiltration or metastasis originating from hepatocellular carcinoma. Int J Surg Case Rep. 2018;46:56-61doi: 10.1016/j.ijscr.2018.03.044.
Nanashima, A., Tominaga, T., Sumida, Y., Tobinaga, S., & Nagayasu, T. (2018). Indocyanine green identification for tumor infiltration or metastasis originating from hepatocellular carcinoma. International journal of surgery case reports, 4656-61. https://doi.org/10.1016/j.ijscr.2018.03.044
Nanashima, Atsushi, et al. "Indocyanine green identification for tumor infiltration or metastasis originating from hepatocellular carcinoma." International journal of surgery case reports vol. 46 (2018): 56-61. doi: https://doi.org/10.1016/j.ijscr.2018.03.044
Nanashima A, Tominaga T, Sumida Y, Tobinaga S, Nagayasu T. Indocyanine green identification for tumor infiltration or metastasis originating from hepatocellular carcinoma. Int J Surg Case Rep. 2018;46:56-61. doi: 10.1016/j.ijscr.2018.03.044. Epub 2018 Apr 16. PMID: 29684806; PMCID: PMC6000743.
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Int J Surg Case Rep. 2018;46:56-61. doi: 10.1016/j.ijscr.2018.03.044. Epub 2018 Apr 16.

Indocyanine green identification for tumor infiltration or metastasis originating from hepatocellular carcinoma.

International journal of surgery case reports

Atsushi Nanashima, Tetsuro Tominaga, Yorihisa Sumida, Shuichi Tobinaga, Takeshi Nagayasu

Affiliations

  1. Division of Hepato-biliary-pancreas and Digestive Surgery, Department of Surgery, University of Miyazaki Faculty of Medicine, Kiyotake 5200, Miyazaki, 889-1692, Japan; Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. Electronic address: [email protected].
  2. Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.

PMID: 29684806 PMCID: PMC6000743 DOI: 10.1016/j.ijscr.2018.03.044

Abstract

INTRODUCTION: The indocyanine green-photodynamic eye (ICG-PDE) system is useful to detect small hypervascular liver tumors, hepatocellular carcinoma (HCC), on the liver surface. This system may be also applied to improve determining the location of metastasis or tumor thrombus (TT). We herein report three case reports. ICG was administered preoperatively for functional testing and images of the tumor were observed during hepatectomy using a PDE camera.

CASE SERIES: The patient in case 1 exhibited advanced HCC with TT in the portal trunk. The TT in the right portal vein was clearly fluorescent by ICG-PDE and the right portal vein was adequately transected to remove TT. The patient in case 2 exhibited a large HCC in the right liver and the right adrenal gland was simultaneously swollen with enhancement. By confirming the fluorescent spot in the right adrenal gland, the metastasized lesion was completely resected. The patient in case 3 previously underwent central bi-segmentectomy, and lymph node metastasis and TT in the vena cava was observed during one-year follow-up. Although it was difficult to detect the definite margin of these lesions by the outline appearance, both lesions could be clearly observed with strong fluorescence and were completely resected.

DISCUSSION AND CONCLUSION: ICG-PDE is a useful tool for detecting the precise tumor location even in extrahepatic tumor lesions, such as metastases or tumor thrombus, which is useful for deciding which parts to resect.

Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Keywords: Hepatectomy; Hepatocellular carcinoma; Identification; Indocyanine green-photodynamic eye; Metastasis; Tumor thrombus

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