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Son GH, Cha HK, Chung S, et al. Multimodal Regulation of Circadian Glucocorticoid Rhythm by Central and Adrenal Clocks. J Endocr Soc. 2018;2(5):444-459doi: 10.1210/js.2018-00021.
Son, G. H., Cha, H. K., Chung, S., & Kim, K. (2018). Multimodal Regulation of Circadian Glucocorticoid Rhythm by Central and Adrenal Clocks. Journal of the Endocrine Society, 2(5), 444-459. https://doi.org/10.1210/js.2018-00021
Son, Gi Hoon, et al. "Multimodal Regulation of Circadian Glucocorticoid Rhythm by Central and Adrenal Clocks." Journal of the Endocrine Society vol. 2,5 (2018): 444-459. doi: https://doi.org/10.1210/js.2018-00021
Son GH, Cha HK, Chung S, Kim K. Multimodal Regulation of Circadian Glucocorticoid Rhythm by Central and Adrenal Clocks. J Endocr Soc. 2018 Apr 06;2(5):444-459. doi: 10.1210/js.2018-00021. eCollection 2018 May 01. PMID: 29713692; PMCID: PMC5915959.
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J Endocr Soc. 2018 Apr 06;2(5):444-459. doi: 10.1210/js.2018-00021. eCollection 2018 May 01.

Multimodal Regulation of Circadian Glucocorticoid Rhythm by Central and Adrenal Clocks.

Journal of the Endocrine Society

Gi Hoon Son, Hyo Kyeong Cha, Sooyoung Chung, Kyungjin Kim

Affiliations

  1. Department of Biomedical Sciences, College of Medicine, Korea University, Seoul, Korea.
  2. Department of Brain and Cognitive Sciences, Scranton College, Ewha Womans University, Seoul, Korea.
  3. Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Korea.
  4. Korea Brain Research Institute, Daegu, Korea.

PMID: 29713692 PMCID: PMC5915959 DOI: 10.1210/js.2018-00021

Abstract

Adrenal glucocorticoids (GCs) control a wide range of physiological processes, including metabolism, cardiovascular and pulmonary activities, immune and inflammatory responses, and various brain functions. During stress responses, GCs are secreted through activation of the hypothalamic-pituitary-adrenal axis, whereas circulating GC levels in unstressed states follow a robust circadian oscillation with a peak around the onset of the active period of a day. A recent advance in chronobiological research has revealed that multiple regulatory mechanisms, along with classical neuroendocrine regulation, underlie this GC circadian rhythm. The hierarchically organized circadian system, with a central pacemaker in the suprachiasmatic nucleus of the hypothalamus and local oscillators in peripheral tissues, including the adrenal gland, mediates periodicities in physiological processes in mammals. In this review, we primarily focus on our understanding of the circadian regulation of adrenal GC rhythm, with particular attention to the cooperative actions of the suprachiasmatic nucleus central and adrenal local clocks, and the clinical implications of this rhythm in human diseases.

Keywords: adrenal gland; circadian clock; circadian rhythm; glucocorticoid; hypothalamic-pituitary-adrenal axis

Conflict of interest statement

The authors have nothing to disclose.

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