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Azadbakht MK, Hassanshahi J, Nematbakhsh M. The Role of Angiotensin II Infusion on the Baroreflex Sensitivity and Renal Function in Intact and Bilateral Renal Denervation Rats. Adv Biomed Res. 2018;7:52doi: 10.4103/abr.abr_192_17.
Azadbakht, M. K., Hassanshahi, J., & Nematbakhsh, M. (2018). The Role of Angiotensin II Infusion on the Baroreflex Sensitivity and Renal Function in Intact and Bilateral Renal Denervation Rats. Advanced biomedical research, 752. https://doi.org/10.4103/abr.abr_192_17
Azadbakht, Mohammad Karim, et al. "The Role of Angiotensin II Infusion on the Baroreflex Sensitivity and Renal Function in Intact and Bilateral Renal Denervation Rats." Advanced biomedical research vol. 7 (2018): 52. doi: https://doi.org/10.4103/abr.abr_192_17
Azadbakht MK, Hassanshahi J, Nematbakhsh M. The Role of Angiotensin II Infusion on the Baroreflex Sensitivity and Renal Function in Intact and Bilateral Renal Denervation Rats. Adv Biomed Res. 2018 Mar 27;7:52. doi: 10.4103/abr.abr_192_17. eCollection 2018. PMID: 29657937; PMCID: PMC5887788.
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Adv Biomed Res. 2018 Mar 27;7:52. doi: 10.4103/abr.abr_192_17. eCollection 2018.

The Role of Angiotensin II Infusion on the Baroreflex Sensitivity and Renal Function in Intact and Bilateral Renal Denervation Rats.

Advanced biomedical research

Mohammad Karim Azadbakht, Jalal Hassanshahi, Mehdi Nematbakhsh

Affiliations

  1. Water and Electrolytes Research Center/Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.

PMID: 29657937 PMCID: PMC5887788 DOI: 10.4103/abr.abr_192_17

Abstract

BACKGROUND: The role of renin-angiotensin system (RAS) in communication between renal system and cardiovascular system is extremely important. Baroreflex sensitivity (BRS) index defines as heart rate (HR) alteration versus mean arterial pressure (MAP) change ratio . Sympathetic nerve is arm of the baroreflexes and any change in its activity will lead to change in the BRS. The role of angiotensin II (Ang II) infusion in systemic circulation accompanied with bilateral renal denervation (RDN) on BRS index and renal function was studied.

MATERIALS AND METHODS: Seventy-two male and female Wistar rats in 12 groups were anesthetized and catheterized. The alteration of MAP and HR responses to phenylephrine infusion compared to control groups was determined in bilateral RDN rats subjected to treat with Ang II (300 or 1000 ng/kg/min) administration.

RESULTS: The BRS index was elevated in Ang II-treated non-RDN (normal) male rats gradually and dose dependently (

CONCLUSION: The Ang II infusion could increase the BRS index in non-RDN (normal) male rats which is significantly greater than BRS index in RDN rats.

Keywords: Angiotensin II; baroreflex sensitivity; renal denervation

Conflict of interest statement

There are no conflicts of interest.

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