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Konugolu Venkata Sekar S, Mosca S, Tannert S, et al. Time domain diffuse Raman spectrometer based on a TCSPC camera for the depth analysis of diffusive media. Opt Lett. 2018;43(9):2134-2137doi: 10.1364/OL.43.002134.
Konugolu Venkata Sekar, S., Mosca, S., Tannert, S., Valentini, G., Martelli, F., Binzoni, T., Prokazov, Y., Turbin, E., Zuschratter, W., Erdmann, R., & Pifferi, A. (2018). Time domain diffuse Raman spectrometer based on a TCSPC camera for the depth analysis of diffusive media. Optics letters, 43(9), 2134-2137. https://doi.org/10.1364/OL.43.002134
Konugolu Venkata Sekar, S, et al. "Time domain diffuse Raman spectrometer based on a TCSPC camera for the depth analysis of diffusive media." Optics letters vol. 43,9 (2018): 2134-2137. doi: https://doi.org/10.1364/OL.43.002134
Konugolu Venkata Sekar S, Mosca S, Tannert S, Valentini G, Martelli F, Binzoni T, Prokazov Y, Turbin E, Zuschratter W, Erdmann R, Pifferi A. Time domain diffuse Raman spectrometer based on a TCSPC camera for the depth analysis of diffusive media. Opt Lett. 2018 May 01;43(9):2134-2137. doi: 10.1364/OL.43.002134. PMID: 29714764.
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Opt Lett. 2018 May 01;43(9):2134-2137. doi: 10.1364/OL.43.002134.

Time domain diffuse Raman spectrometer based on a TCSPC camera for the depth analysis of diffusive media.

Optics letters

S Konugolu Venkata Sekar, S Mosca, S Tannert, G Valentini, F Martelli, T Binzoni, Y Prokazov, E Turbin, W Zuschratter, R Erdmann, A Pifferi

PMID: 29714764 DOI: 10.1364/OL.43.002134

Abstract

We present a time domain diffuse Raman spectrometer for depth probing of highly scattering media. The system is based on, to the best of our knowledge, a novel time-correlated single-photon counting (TCSPC) camera that simultaneously acquires both spectral and temporal information of Raman photons. A dedicated non-contact probe was built, and time domain Raman measurements were performed on a tissue mimicking bilayer phantom. The fluorescence contamination of the Raman signal was eliminated by early time gating (0-212 ps) the Raman photons. Depth sensitivity is achieved by time gating Raman photons at different delays with a gate width of 106 ps. Importantly, the time domain can provide time-dependent depth sensitivity leading to a high contrast between two layers of Raman signal. As a result, an enhancement factor of 2170 was found for our bilayer phantom which is much higher than the values obtained by spatial offset Raman spectroscopy (SORS), frequency offset Raman spectroscopy (FORS), or hybrid FORS-SORS on a similar phantom.

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