Saudi J Biol Sci. 2018 Mar;25(3):487-492. doi: 10.1016/j.sjbs.2017.08.009. Epub 2017 Aug 18.

Effects of total flavonoids of raspberry on perimenopausal model in mice.

Saudi journal of biological sciences

Zhenna Fu, Zhenzhen Wei, Mingsan Miao

PMID: 29686512 PMCID: PMC5910651 DOI: 10.1016/j.sjbs.2017.08.009

Abstract

To study the effect of raspberry total flavonoids on perimenopausal model in mice. Blank group, sham operation, and the rest of the mice made the menopausal model. Choose 72 mice castrated completely random divided into 6 groups for the experiment, respectively: model group, gengnianan (GNA) capsule group, soybean isoflavone soft (SIS) capsule group, high, mid and low dose group of total flavonoids of raspberry (TFR). Animals in each group were given the corresponding drugs tenth days after operation, and were given intragastrical administration of once a day for continuous administration of 21 days. Each group of mice in the administration of 18 days to determine the number of autonomic activities within 5 min, in the administration of 19-20 days to determine the incubation of the mice first entry into the darkroom and the number of shocks into the darkroom within 5 min. At 2 h after the last administration (fasting for 12 h), mice were sacrificed and serum was collected. Serum levels of E2, T, LH and FSH were measured. Dissect the uterus, uterus, thymus and spleen. Weigh the wet weight and calculate the organ index, the morphological changes of uterus, thymus and spleen were observed. The results showed that the TFR had a good therapeutic effect on the perimenopausal model of mice after giving a high, mid and low dose of raspberry flavonoids for some time.

Keywords: Autonomic activity; Memory; Perimenopausal model; Sex hormone levels; Total flavonoids of raspberry (TFR)

References

1. Brain Res. 2011 Mar 16;1379:188-98 - PubMed
2. Zhongguo Zhong Yao Za Zhi. 2013 Dec;38(24):4351-6 - PubMed
3. Saudi Pharm J. 2017 May;25(4):548-555 - PubMed

Publication Types

• Journal Article