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Tkaczyk M, Tomczyk D, Jander A, et al. Glomerular filtration decrease after diagnostic cardiac catheterisation in children with congenital cardiac malformation - the role of serum creatinine, cystatin C, neutrophil gelatinase and urine output monitoring. Postepy Kardiol Interwencyjnej. 2018;14(1):67-74doi: 10.5114/aic.2018.74357.
Tkaczyk, M., Tomczyk, D., Jander, A., Góreczny, S., Moszura, T., Dryżek, P., Krajewski, W., Głowacka, E., & Wosiak, A. (2018). Glomerular filtration decrease after diagnostic cardiac catheterisation in children with congenital cardiac malformation - the role of serum creatinine, cystatin C, neutrophil gelatinase and urine output monitoring. Postepy w kardiologii interwencyjnej = Advances in interventional cardiology, 14(1), 67-74. https://doi.org/10.5114/aic.2018.74357
Tkaczyk, Marcin, et al. "Glomerular filtration decrease after diagnostic cardiac catheterisation in children with congenital cardiac malformation - the role of serum creatinine, cystatin C, neutrophil gelatinase and urine output monitoring." Postepy w kardiologii interwencyjnej = Advances in interventional cardiology vol. 14,1 (2018): 67-74. doi: https://doi.org/10.5114/aic.2018.74357
Tkaczyk M, Tomczyk D, Jander A, Góreczny S, Moszura T, Dryżek P, Krajewski W, Głowacka E, Wosiak A. Glomerular filtration decrease after diagnostic cardiac catheterisation in children with congenital cardiac malformation - the role of serum creatinine, cystatin C, neutrophil gelatinase and urine output monitoring. Postepy Kardiol Interwencyjnej. 2018;14(1):67-74. doi: 10.5114/aic.2018.74357. Epub 2018 Mar 22. PMID: 29743906; PMCID: PMC5939547.
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Postepy Kardiol Interwencyjnej. 2018;14(1):67-74. doi: 10.5114/aic.2018.74357. Epub 2018 Mar 22.

Glomerular filtration decrease after diagnostic cardiac catheterisation in children with congenital cardiac malformation - the role of serum creatinine, cystatin C, neutrophil gelatinase and urine output monitoring.

Postepy w kardiologii interwencyjnej = Advances in interventional cardiology

Marcin Tkaczyk, Daria Tomczyk, Anna Jander, Sebastian Góreczny, Tomasz Moszura, Paweł Dryżek, Wojciech Krajewski, Ewa Głowacka, Agnieszka Wosiak

Affiliations

  1. Department of Paediatrics, Immunology and Nephrology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
  2. Division of Didactics in Paediatrics, Medical University of Lodz, Lodz, Poland.
  3. Scientific Laboratory of Hypertension and Cardiovascular Diseases, Department of Paediatrics, Immunology and Nephrology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
  4. Department of Cardiology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
  5. Department of Anaesthesiology and Intensive Care, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
  6. Centre of Medical Diagnostics, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
  7. Institute of Information Technology, Lodz University of Technology, Lodz, Poland.

PMID: 29743906 PMCID: PMC5939547 DOI: 10.5114/aic.2018.74357

Abstract

INTRODUCTION: Diagnosis of contrast induced-nephropathy (CIN) by a classic renal biomarker such as creatinine concentration can be delayed because of various factors that can influence this marker. Changes in new biomarkers such as neutrophil-gelatinase associated lipocalin (NGAL) and cystatin C are postulated to be more sensitive for recognizing patients prone to CIN-acute kidney injury (AKI).

AIM: To investigate the role of NGAL and cystatin C as early biomarkers in the diagnosis of kidney injury after cardiac catheterisation.

MATERIAL AND METHODS: The study group consisted of 50 patients with congenital heart malformation admitted for scheduled cardiac catheterisation. The biomarkers serum creatinine, serum NGAL and serum cystatin C were tested at 5 time-points sequentially from start to 48 h after the procedure.

RESULTS: Significant changes were noted during the research in the serum creatinine concentration (

CONCLUSIONS: We observed a transient decrease in eGFR and a rise of serum NGAL after 2 h but NGAL was most pronounced at 6 h after the procedure. The potential role of cystatin C as a biomarker of CIN-AKI was not proved.

Keywords: cardiac catheterization; children; contrast-induced acute kidney injury

Conflict of interest statement

The authors declare no conflict of interest.

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