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Shi S, Nguyen PK, Cabral HJ, et al. Development of peptide inhibitors of HIV transmission. Bioact Mater. 2016;1(2):109-121doi: 10.1016/j.bioactmat.2016.09.004.
Shi, S., Nguyen, P. K., Cabral, H. J., Diez-Barroso, R., Derry, P. J., Kanahara, S. M., & Kumar, V. A. (2016). Development of peptide inhibitors of HIV transmission. Bioactive materials, 1(2), 109-121. https://doi.org/10.1016/j.bioactmat.2016.09.004
Shi, Siyu, et al. "Development of peptide inhibitors of HIV transmission." Bioactive materials vol. 1,2 (2016): 109-121. doi: https://doi.org/10.1016/j.bioactmat.2016.09.004
Shi S, Nguyen PK, Cabral HJ, Diez-Barroso R, Derry PJ, Kanahara SM, Kumar VA. Development of peptide inhibitors of HIV transmission. Bioact Mater. 2016 Sep 16;1(2):109-121. doi: 10.1016/j.bioactmat.2016.09.004. eCollection 2016 Dec. PMID: 29744399; PMCID: PMC5883972.
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Bioact Mater. 2016 Sep 16;1(2):109-121. doi: 10.1016/j.bioactmat.2016.09.004. eCollection 2016 Dec.

Development of peptide inhibitors of HIV transmission.

Bioactive materials

Siyu Shi, Peter K Nguyen, Henry J Cabral, Ramon Diez-Barroso, Paul J Derry, Satoko M Kanahara, Vivek A Kumar

Affiliations

  1. Department of Chemistry, Rice University, Houston, TX 77030, USA.
  2. Department of Biomedical Engineering, New Jersey Institute of Technology, University Heights, Newark, NJ 07102, USA.
  3. Department of Chemical, Biological and Pharmaceutical Engineering, New Jersey Institute of Technology, University Heights, Newark, NJ 07102, USA.
  4. Baylor College of Medicine, Houston, TX 77030, USA.
  5. Community Healthcare Network, New York, NY 10010, USA.

PMID: 29744399 PMCID: PMC5883972 DOI: 10.1016/j.bioactmat.2016.09.004

Abstract

Treatment of HIV has long faced the challenge of high mutation rates leading to rapid development of resistance, with ongoing need to develop new methods to effectively fight the infection. Traditionally, early HIV medications were designed to inhibit RNA replication and protein production through small molecular drugs. Peptide based therapeutics are a versatile, promising field in HIV therapy, which continues to develop as we expand our understanding of key protein-protein interactions that occur in HIV replication and infection. This review begins with an introduction to HIV, followed by the biological basis of disease, current clinical management of the disease, therapeutics on the market, and finally potential avenues for improved drug development.

Keywords: AIDS, acquired immunodeficiency syndrome; ART, antiretroviral therapy; CDC, Centers for Disease Control and Prevention; Drug development; FDA, US Food and Drug Administration; FY, fiscal year; HAART, highly active antiretroviral therapy; HCV, hepatitis C Virus; HIV; HIV treatment; HIV, human immunodeficiency virus; INSTI, Integrase strand transfer inhibitors; LEDGF, lens epithelium-derived growth factor; NNRTI, Non-nucleoside reverse transcriptase inhibitors; NRTI, Nucleoside/Nucleotide Reverse Transcriptase Inhibitors; Peptide inhibitor; Peptide therapeutic; R&D, research and development; RT, reverse transcriptase

References

  1. Methods Mol Biol. 2008;494:1-8 - PubMed
  2. MAbs. 2010 May-Jun;2(3):266-74 - PubMed
  3. Lancet. 2011 Jul 16;378(9787):279-81 - PubMed
  4. Curr Med Chem. 2003 Sep;10(18):1765-78 - PubMed
  5. Antimicrob Agents Chemother. 2009 Mar;53(3):1013-8 - PubMed
  6. Bioorg Med Chem. 2009 Feb 1;17(3):967-76 - PubMed
  7. JAMA. 1992 Nov 18;268(19):2662-6 - PubMed
  8. Top Antivir Med. 2013 Feb-Mar;21(1):6-14 - PubMed
  9. J Clin Invest. 1990 Oct;86(4):1142-50 - PubMed
  10. Curr HIV Res. 2011 Jan;9(1):1-5 - PubMed
  11. Antimicrob Agents Chemother. 2012 May;56(5):2347-56 - PubMed
  12. N Engl J Med. 2003 Feb 20;348(8):702-10 - PubMed
  13. Proc Natl Acad Sci U S A. 1989 Sep;86(18):7139-43 - PubMed
  14. Mol Ther. 2011 Dec;19(12):2228-38 - PubMed
  15. Org Biomol Chem. 2003 Jan 7;1(1):5-14 - PubMed
  16. FEBS J. 2012 Aug;279(16):2795-809 - PubMed
  17. N Engl J Med. 2014 Mar 6;370(10):901-10 - PubMed
  18. Rev Med Virol. 2016 Jan;26(1):4-20 - PubMed
  19. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):11931-6 - PubMed
  20. Antimicrob Agents Chemother. 2014 Sep;58(9):5125-35 - PubMed
  21. Emerg Infect Dis. 1997 Jul-Sep;3(3):253-9 - PubMed
  22. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1901-3 - PubMed
  23. Eur J Biochem. 1996 Sep 15;240(3):765-73 - PubMed
  24. Drug Discov Today. 2007 Sep;12(17-18):777-85 - PubMed
  25. Curr Pharm Des. 2002;8(8):615-57 - PubMed
  26. AIDS. 2008 Nov 12;22(17):2393-5 - PubMed
  27. Pharm Res. 2006 Nov;23(11):2638-45 - PubMed
  28. PLoS Pathog. 2011 May;7(5):e1002038 - PubMed
  29. J Biol Chem. 2003 Feb 21;278(8):6596-602 - PubMed
  30. Virology. 2015 Jan 15;475:179-86 - PubMed
  31. Int J Pharm. 2008 Mar 3;351(1-2):271-81 - PubMed
  32. AIDS. 2016 Jan 28;30(3):377-82 - PubMed
  33. J Mol Biol. 2007 Jun 22;369(5):1230-43 - PubMed
  34. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3727-32 - PubMed
  35. AIDS. 2014 Nov 28;28(18):2751-62 - PubMed
  36. Biochemistry. 2001 Nov 20;40(46):13840-8 - PubMed
  37. J Virol. 2012 Sep;86(18):10218-20 - PubMed
  38. J Virol. 2010 Jun;84(11):5842-5 - PubMed
  39. N Engl J Med. 2015 Aug 27;373(9):795-807 - PubMed
  40. Nucleic Acids Res. 2006;34(18):5157-65 - PubMed
  41. PLoS One. 2014 Jun 25;9(6):e98354 - PubMed
  42. Farmaco. 2001 Jan-Feb;56(1-2):3-12 - PubMed
  43. J Biol Chem. 1991 Aug 25;266(24):15591-4 - PubMed
  44. Antiviral Res. 2010 Jan;85(1):59-74 - PubMed
  45. Virology. 2012 Aug 15;430(1):53-62 - PubMed
  46. BMJ. 2009 Jan 26;338:a3172 - PubMed
  47. Curr HIV Res. 2004 Oct;2(4):323-32 - PubMed
  48. J Biol Chem. 2002 Dec 13;277(50):48816-26 - PubMed
  49. Curr Pharm Des. 2013;19(10):1810-7 - PubMed
  50. J Mol Biol. 2008 May 2;378(3):565-80 - PubMed
  51. Methods. 2011 Jun;54(2):284-94 - PubMed
  52. Lancet. 2014 Jul 19;384(9939):258-71 - PubMed
  53. PLoS Pathog. 2010 Oct 28;6(10):e1001067 - PubMed
  54. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11244-9 - PubMed
  55. Drug Discov Today. 2015 Jan;20(1):122-8 - PubMed
  56. Biochemistry. 2003 Dec 23;42(50):14711-9 - PubMed
  57. J Infect Dis. 2013 Jun 15;207 Suppl 2:S78-84 - PubMed
  58. Biophys Chem. 2012 Aug-Sep;170:9-16 - PubMed
  59. J Gen Virol. 1994 Jun;75 ( Pt 6):1469-74 - PubMed
  60. Nat Immunol. 2006 Nov;7(11):1209-16 - PubMed
  61. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1175-7 - PubMed
  62. JAMA. 1993 Feb 10;269(6):729-30 - PubMed
  63. Eur J Pharm Biopharm. 2009 Aug;72(3):502-8 - PubMed
  64. Curr Opin Virol. 2012 Oct;2(5):656-62 - PubMed
  65. Science. 2009 Mar 6;323(5919):1304-7 - PubMed
  66. AIDS Rev. 2004 Jan-Mar;6(1):61 - PubMed
  67. Med Chem. 2015;11(3):235-47 - PubMed
  68. N Engl J Med. 1997 Mar 27;336(13):919-22 - PubMed
  69. J Gen Virol. 1998 Apr;79 ( Pt 4):731-40 - PubMed
  70. Eur J Biochem. 2002 Nov;269(21):5103-11 - PubMed
  71. Eur J Biochem. 1999 Feb;260(1):145-55 - PubMed
  72. Blood. 2011 Mar 10;117(10):2791-9 - PubMed
  73. Ann Biomed Eng. 2015 Mar;43(3):641-56 - PubMed
  74. Adv Drug Deliv Rev. 2010 Mar 18;62(4-5):491-502 - PubMed
  75. AIDS Patient Care STDS. 2010 Feb;24(2):79-85 - PubMed
  76. J Med Chem. 2006 Jul 27;49(15):4657-64 - PubMed
  77. Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6 - PubMed
  78. Curr Opin Drug Discov Devel. 2003 Jul;6(4):451-61 - PubMed
  79. J Biol Chem. 2009 Jan 2;284(1):254-64 - PubMed
  80. Biophys J. 2010 Nov 17;99(10):3445-53 - PubMed
  81. Indian J Pharmacol. 2012 May;44(3):288-98 - PubMed
  82. Clin Infect Dis. 2016 Feb 1;62(3):392-6 - PubMed
  83. Pharmaceuticals (Basel). 2013 Aug 21;6(8):1055-81 - PubMed
  84. J Virol. 1993 Nov;67(11):6841-6 - PubMed
  85. Peptides. 2014 Jul;57:67-77 - PubMed
  86. PLoS One. 2015 Oct 30;10(11):e0139562 - PubMed
  87. Int J Pharm. 2007 Jun 29;338(1-2):198-206 - PubMed
  88. Adv Exp Med Biol. 2012;726:223-42 - PubMed
  89. J Virol. 2015 May;89(9):4827-36 - PubMed
  90. Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11052-6 - PubMed
  91. Chem Biol Drug Des. 2013 Jan;81(1):136-47 - PubMed
  92. Virology. 2013 Jan 5;435(1):102-9 - PubMed
  93. N Engl J Med. 2009 Feb 12;360(7):692-8 - PubMed
  94. J Med Chem. 2016 Jun 9;59(11):5172-208 - PubMed
  95. FEBS Lett. 2000 May 4;473(1):15-8 - PubMed
  96. ACS Chem Biol. 2016 Jan 15;11(1):88-94 - PubMed
  97. Clin Pharmacokinet. 2008;47(6):351-71 - PubMed
  98. Eur J Pharm Sci. 2008 Jul 3;34(2-3):181-9 - PubMed
  99. Clin Infect Dis. 2012 Jun;54(11):1660-9 - PubMed
  100. Antimicrob Agents Chemother. 2012 Dec;56(12):6272-83 - PubMed
  101. J Virol. 2010 Nov;84(21):11235-44 - PubMed
  102. Clin Infect Dis. 2015 Feb 15;60(4):627-38 - PubMed
  103. Curr Pharm Des. 2010;16(33):3716-28 - PubMed
  104. Biochem Pharmacol. 2003 Apr 1;65(7):1097-102 - PubMed
  105. Antiviral Res. 2010 Jan;85(1):91-100 - PubMed
  106. J Int AIDS Soc. 2013 Sep 04;16:1-14 - PubMed
  107. AIDS Res Hum Retroviruses. 2011 Aug;27(8):853-62 - PubMed
  108. Eur J Immunol. 2005 Feb;35(2):505-14 - PubMed
  109. J Virol. 2009 Oct;83(20):10358-65 - PubMed
  110. Trends Mol Med. 2015 Jun;21(6):341-53 - PubMed
  111. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5595-8 - PubMed
  112. Curr HIV Res. 2008 Sep;6(5):388-400 - PubMed
  113. J Biol Chem. 1999 Aug 27;274(35):24941-6 - PubMed
  114. J Biol Chem. 2007 May 25;282(21):15743-53 - PubMed
  115. Crit Care. 2003 Jun;7(3):226-32 - PubMed
  116. Biol Chem. 1999 May;380(5):593-6 - PubMed
  117. ACS Chem Biol. 2008 Dec 19;3(12):757-64 - PubMed
  118. J Acquir Immune Defic Syndr. 2008 Sep 1;49 Suppl 2:S79-85 - PubMed
  119. Retrovirology. 2009 Mar 05;6:25 - PubMed
  120. Antiviral Res. 2006 Nov;72(2):89-99 - PubMed
  121. Nat Struct Mol Biol. 2005 Aug;12(8):671-7 - PubMed
  122. Biophys J. 2011 Mar 2;100(5):1325-34 - PubMed
  123. Drugs. 2012 Jun 18;72(9):e1-25 - PubMed
  124. Biochem J. 2009 Apr 15;419(2):497-506 - PubMed
  125. Nat Rev Microbiol. 2012 Mar 16;10 (4):279-90 - PubMed
  126. AIDS Res Hum Retroviruses. 2012 May;28(5):425-34 - PubMed
  127. Oral Dis. 2016 Apr;22 Suppl 1:42-5 - PubMed
  128. J Mol Biol. 1998 Oct 23;283(2):475-88 - PubMed
  129. Chembiochem. 2011 Oct 17;12(15):2311-5 - PubMed
  130. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18921-5 - PubMed
  131. Rev Med Virol. 2004 Jul-Aug;14(4):255-70 - PubMed
  132. Antiviral Res. 2010 Jan;85(1):39-58 - PubMed
  133. J Pharm Sci. 2008 Dec;97(12):5421-33 - PubMed
  134. Cold Spring Harb Perspect Med. 2012 Apr;2(4):a007161 - PubMed
  135. Curr Pharm Des. 2009;15(21):2508-19 - PubMed
  136. Antiviral Res. 2010 Jan;85(1):75-90 - PubMed
  137. PLoS One. 2008 Jul 02;3(7):e2580 - PubMed
  138. ACS Nano. 2015 Jan 27;9(1):860-8 - PubMed
  139. Ther Clin Risk Manag. 2008 Apr;4(2):493-500 - PubMed
  140. ChemMedChem. 2010 Nov 8;5(11):1813-24 - PubMed
  141. J Med Chem. 2012 Aug 9;55(15):6762-75 - PubMed
  142. J Infect Dis. 2013 Jun 15;207 Suppl 2:S49-56 - PubMed
  143. Nat Rev Drug Discov. 2004 Mar;3(3):215-25 - PubMed
  144. N Engl J Med. 2010 Dec 30;363(27):2587-99 - PubMed
  145. J Biol Chem. 2014 Jul 18;289(29):20222-33 - PubMed
  146. Trends Microbiol. 2011 Apr;19(4):191-7 - PubMed
  147. Nat Mater. 2016 Jan;15(1):13-26 - PubMed
  148. Am J Epidemiol. 1995 Apr 1;141(7):645-51 - PubMed
  149. AIDS Res Hum Retroviruses. 2013 Jun;29(6):925-30 - PubMed
  150. J Virol. 2013 May;87(10):5868-81 - PubMed
  151. J Infect Dis. 2005 Apr 1;191(7):1155-63 - PubMed
  152. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6574-8 - PubMed
  153. Curr Opin Virol. 2015 Oct;14:24-9 - PubMed
  154. J Biol Chem. 1994 May 6;269(18):13080-3 - PubMed
  155. Antiviral Res. 2012 Dec;96(3):430-6 - PubMed
  156. J Basic Microbiol. 2015 Feb;55(2):269-75 - PubMed
  157. Chembiochem. 2010 Jul 26;11(11):1513-6 - PubMed
  158. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5199-202 - PubMed
  159. Nucleosides Nucleotides Nucleic Acids. 2015;34(1):1-15 - PubMed
  160. Antivir Chem Chemother. 2009 Oct 19;20(2):79-85 - PubMed
  161. Macromol Biosci. 2015 Jan;15(1):9-35 - PubMed
  162. Nature. 1988 Jan 21;331(6153):280-3 - PubMed
  163. J Antimicrob Chemother. 2009 Dec;64(6):1192-5 - PubMed
  164. Future Med Chem. 2015;7(8):1055-77 - PubMed
  165. J Mol Biol. 2007 Jun 15;369(4):1041-51 - PubMed
  166. J Int Assoc Provid AIDS Care. 2017 Jul/Aug;16(4):338-346 - PubMed
  167. Expert Opin Biol Ther. 2002 Oct;2(7):751-61 - PubMed
  168. Biomacromolecules. 2002 May-Jun;3(3):421-31 - PubMed
  169. Antimicrob Agents Chemother. 2015 Jul;59(7):3913-9 - PubMed
  170. AIDS Res Hum Retroviruses. 1996 Dec 10;12(18):1709-15 - PubMed
  171. Antiviral Res. 1996 May;30(2-3):155-70 - PubMed
  172. AIDS. 2010 Nov 13;24(17):2705-15 - PubMed
  173. PLoS One. 2012;7(5):e37381 - PubMed
  174. J Biol Chem. 2011 Feb 18;286(7):4978-90 - PubMed
  175. J Acquir Immune Defic Syndr. 2015 Aug 15;69(5):576-84 - PubMed
  176. Am J Epidemiol. 2015 Jan 1;181(1):40-53 - PubMed
  177. Clin Infect Dis. 2014 Jul 15;59(2):265-71 - PubMed
  178. Lancet. 2007 Jul 7;370(9581):81-8 - PubMed
  179. FEBS Lett. 2008 Apr 30;582(10):1425-30 - PubMed
  180. Peptides. 2015 Sep;71:296-303 - PubMed
  181. Appl Biochem Biotechnol. 2015 Mar;175(5):2456-67 - PubMed
  182. Nat Rev Drug Discov. 2003 Oct;2(10):812-22 - PubMed
  183. Mol Pharm. 2013 Oct 7;10(10):3531-43 - PubMed
  184. Cold Spring Harb Perspect Med. 2012 Aug 01;2(8):null - PubMed
  185. Protein Sci. 1992 Oct;1(10):1244-53 - PubMed
  186. PLoS One. 2013;8(1):e54908 - PubMed
  187. Mol Pharmacol. 2011 Oct;80(4):565-72 - PubMed
  188. Trends Pharmacol Sci. 2010 Feb;31(2):74-81 - PubMed
  189. Biochim Biophys Acta. 2016 Jun;1860(6):1139-48 - PubMed
  190. Virology. 2007 Feb 5;358(1):148-58 - PubMed
  191. Biochemistry. 2011 Mar 15;50(10):1567-81 - PubMed
  192. Exp Biol Med (Maywood). 2016 May;241(9):899-908 - PubMed
  193. J Biol Chem. 1995 Dec 1;270(48):28642-6 - PubMed
  194. Int J Pharm. 2009 Mar 31;370(1-2):167-74 - PubMed
  195. Curr Opin HIV AIDS. 2013 Nov;8(6):586-90 - PubMed
  196. N Engl J Med. 1993 Jan 28;328(4):288-9 - PubMed
  197. Antivir Ther. 2014;19 Suppl 3:5-14 - PubMed
  198. J Virol. 1998 Dec;72(12):9763-70 - PubMed
  199. Drug Deliv Transl Res. 2016 Jun;6(3):234-42 - PubMed
  200. PLoS One. 2011;6(7):e22020 - PubMed
  201. Exp Biol Med (Maywood). 2013 May;238(5):442-9 - PubMed
  202. Curr Top Med Chem. 2016;16(10 ):1074-90 - PubMed
  203. Sci Transl Med. 2010 Dec 22;2(63):63re3 - PubMed
  204. Biochim Biophys Acta. 2007 Apr;1770(4):681-6 - PubMed
  205. Bioorg Med Chem. 2010 Sep 15;18(18):6771-5 - PubMed
  206. J Acquir Immune Defic Syndr. 2015 Apr 1;68(4):425-31 - PubMed
  207. Antiviral Res. 2010 Jan;85(1):25-33 - PubMed
  208. Viruses. 2009 Dec;1(3):1209-39 - PubMed
  209. Science. 2013 Sep 20;341(6152):1387-90 - PubMed
  210. J Biol Chem. 2005 Jun 10;280(23):21987-96 - PubMed
  211. Biomacromolecules. 2014 Jul 14;15(7):2590-9 - PubMed
  212. JAMA. 2014 Jul 23-30;312(4):410-25 - PubMed
  213. J Formos Med Assoc. 2010 Feb;109(2):94-105 - PubMed
  214. ACS Chem Biol. 2008 Dec 19;3(12):745-7 - PubMed
  215. Bioorg Med Chem. 2010 Dec 1;18(23):8388-95 - PubMed
  216. Retrovirology. 2008 Aug 07;5:74 - PubMed
  217. J Virol. 2004 Apr;78(7):3387-97 - PubMed
  218. Pharmacotherapy. 2013 Jul;33(7):765-75 - PubMed
  219. J Virol. 2005 Sep;79(18):11598-606 - PubMed
  220. Biochemistry. 2009 Jan 20;48(2):379-87 - PubMed
  221. J Mol Biol. 2012 Sep 14;422(2):230-44 - PubMed
  222. HIV AIDS (Auckl). 2010;2:135-40 - PubMed
  223. Adv Drug Deliv Rev. 2008 Mar 1;60(4-5):548-58 - PubMed
  224. Adv Drug Deliv Rev. 2001 Mar 23;47(1):3-19 - PubMed
  225. Drug Discov Today. 2010 Jan;15(1-2):40-56 - PubMed
  226. Cell. 1991 Dec 20;67(6):1211-21 - PubMed
  227. J Med Chem. 2010 Jul 22;53(14):5356-60 - PubMed
  228. Curr Opin HIV AIDS. 2008 Nov;3(6):660-5 - PubMed
  229. Nature. 2007 Dec 13;450(7172):1001-9 - PubMed
  230. ChemMedChem. 2010 Nov 8;5(11):1899-906 - PubMed
  231. Biotechnol Adv. 2014 Nov 15;32(7):1269-1282 - PubMed
  232. Clin Infect Dis. 2005 Jul 1;41 Suppl 1:S96-100 - PubMed
  233. Lancet Infect Dis. 2009 Oct;9(10):637-49 - PubMed
  234. HIV AIDS (Auckl). 2015 Apr 08;7:95-104 - PubMed
  235. J Virol. 2012 Nov;86(22):12417-21 - PubMed
  236. Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40 - PubMed
  237. JAMA. 1993 Feb 10;269(6):733 - PubMed
  238. Antimicrob Agents Chemother. 2005 Nov;49(11):4721-32 - PubMed
  239. J Med Toxicol. 2014 Mar;10(1):26-39 - PubMed
  240. Biopolymers. 2016 Nov 4;106(4):476-83 - PubMed
  241. AIDS. 2014 Jun 1;28(9):1297-306 - PubMed
  242. Peptides. 2002 Jun;23(6):1025-9 - PubMed
  243. Ann Intern Med. 1991 Aug 1;115(3):184-9 - PubMed
  244. Science. 1992 Jun 26;256(5065):1783-90 - PubMed
  245. Bioconjug Chem. 2012 Aug 15;23(8):1648-60 - PubMed

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