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Mbangiwa T, Kasvosve I, Anderson M, et al. Chronic and Occult Hepatitis B Virus Infection in Pregnant Women in Botswana. Genes (Basel). 2018;9(5)doi: 10.3390/genes9050259.
Mbangiwa, T., Kasvosve, I., Anderson, M., Thami, P. K., Choga, W. T., Needleman, A., Phinius, B. B., Moyo, S., Leteane, M., Leidner, J., Blackard, J. T., Mayondi, G., Kammerer, B., Musonda, R. M., Essex, M., Lockman, S., & Gaseitsiwe, S. (2018). Chronic and Occult Hepatitis B Virus Infection in Pregnant Women in Botswana. Genes, 9(5), . https://doi.org/10.3390/genes9050259
Mbangiwa, Tshepiso, et al. "Chronic and Occult Hepatitis B Virus Infection in Pregnant Women in Botswana." Genes vol. 9,5 (2018). doi: https://doi.org/10.3390/genes9050259
Mbangiwa T, Kasvosve I, Anderson M, Thami PK, Choga WT, Needleman A, Phinius BB, Moyo S, Leteane M, Leidner J, Blackard JT, Mayondi G, Kammerer B, Musonda RM, Essex M, Lockman S, Gaseitsiwe S. Chronic and Occult Hepatitis B Virus Infection in Pregnant Women in Botswana. Genes (Basel). 2018 May 17;9(5). doi: 10.3390/genes9050259. PMID: 29772814; PMCID: PMC5977199.
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Genes (Basel). 2018 May 17;9(5). doi: 10.3390/genes9050259.

Chronic and Occult Hepatitis B Virus Infection in Pregnant Women in Botswana.

Genes

Tshepiso Mbangiwa, Ishmael Kasvosve, Motswedi Anderson, Prisca K Thami, Wonderful T Choga, Austen Needleman, Bonolo B Phinius, Sikhulile Moyo, Melvin Leteane, Jean Leidner, Jason T Blackard, Gloria Mayondi, Betsy Kammerer, Rosemary M Musonda, Max Essex, Shahin Lockman, Simani Gaseitsiwe

Affiliations

  1. Botswana Harvard AIDS Institute Partnership, Gaborone BO320, Botswana. [email protected].
  2. Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Botswana, Gaborone 0022, Botswana. [email protected].
  3. Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Botswana, Gaborone 0022, Botswana. [email protected].
  4. Botswana Harvard AIDS Institute Partnership, Gaborone BO320, Botswana. [email protected].
  5. Department of Biological Sciences, Faculty of Science, University of Botswana, Gaborone 0022, Botswana. [email protected].
  6. Botswana Harvard AIDS Institute Partnership, Gaborone BO320, Botswana. [email protected].
  7. Department of Biological Sciences, Faculty of Science, University of Botswana, Gaborone 0022, Botswana. [email protected].
  8. Botswana Harvard AIDS Institute Partnership, Gaborone BO320, Botswana. [email protected].
  9. Harvard College, Cambridge, MA 02138, USA. [email protected].
  10. Botswana Harvard AIDS Institute Partnership, Gaborone BO320, Botswana. [email protected].
  11. Botswana Harvard AIDS Institute Partnership, Gaborone BO320, Botswana. [email protected].
  12. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. [email protected].
  13. Department of Biological Sciences, Faculty of Science, University of Botswana, Gaborone 0022, Botswana. [email protected].
  14. Goodtables Data Consulting, Norman, OK 73019, USA. [email protected].
  15. University of Cincinnati College of Medicine, Cincinnati, OH 45627, USA. [email protected].
  16. Botswana Harvard AIDS Institute Partnership, Gaborone BO320, Botswana. [email protected].
  17. Department of Psychiatry, Boston Children's Hospital, Boston, MA 02115, USA. [email protected].
  18. Brigham and Women's Hospital, Boston, MA 02115, USA. [email protected].
  19. Botswana Harvard AIDS Institute Partnership, Gaborone BO320, Botswana. [email protected].
  20. Botswana Harvard AIDS Institute Partnership, Gaborone BO320, Botswana. [email protected].
  21. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. [email protected].
  22. Botswana Harvard AIDS Institute Partnership, Gaborone BO320, Botswana. [email protected].
  23. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. [email protected].
  24. Brigham and Women's Hospital, Boston, MA 02115, USA. [email protected].
  25. Botswana Harvard AIDS Institute Partnership, Gaborone BO320, Botswana. [email protected].
  26. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. [email protected].

PMID: 29772814 PMCID: PMC5977199 DOI: 10.3390/genes9050259

Abstract

The hepatitis B virus (HBV) is a global problem; however, the burden of HBV infection in pregnant women in Botswana is unknown. We sought to determine the prevalence of chronic and occult HBV infection in human immunodeficiency virus (HIV)-infected and -uninfected pregnant women in Botswana. Samples from 752 pregnant women were tested for hepatitis B surface antigen (HBsAg), and HBsAg-positive samples were tested for hepatitis B e antigen (HBeAg) and HBV DNA load. Samples that were HBsAg negative were screened for occult HBV infection by determining the HBV DNA load. HBV genotypes were determined based on a 415-base-pair fragment of the surface gene. Among the 752 women tested during pregnancy or early postpartum, 16 (2.1%) (95% confidence interval (CI): 2.0⁻2.2) were HBsAg-positive. The prevalence of chronic HBV infection was higher (3.1%) among HIV-infected (95% CI: 3.0⁻3.2) compared with HIV-uninfected women (1.1%) (95% CI: 1.07⁻1.1,

Keywords: Botswana; hepatitis B virus (HBV); human immunodeficiency virus (HIV); pregnant women

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