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Middelveen MJ, Sapi E, Burke J, et al. Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease. Healthcare (Basel). 2018;6(2)doi: 10.3390/healthcare6020033.
Middelveen, M. J., Sapi, E., Burke, J., Filush, K. R., Franco, A., Fesler, M. C., & Stricker, R. B. (2018). Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease. Healthcare (Basel, Switzerland), 6(2), . https://doi.org/10.3390/healthcare6020033
Middelveen, Marianne J, et al. "Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease." Healthcare (Basel, Switzerland) vol. 6,2 (2018). doi: https://doi.org/10.3390/healthcare6020033
Middelveen MJ, Sapi E, Burke J, Filush KR, Franco A, Fesler MC, Stricker RB. Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease. Healthcare (Basel). 2018 Apr 14;6(2). doi: 10.3390/healthcare6020033. PMID: 29662016; PMCID: PMC6023324.
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Healthcare (Basel). 2018 Apr 14;6(2). doi: 10.3390/healthcare6020033.

Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease.

Healthcare (Basel, Switzerland)

Marianne J Middelveen, Eva Sapi, Jennie Burke, Katherine R Filush, Agustin Franco, Melissa C Fesler, Raphael B Stricker

Affiliations

  1. Atkins Veterinary Services, Calgary, AB T3B 4C9, Canada. [email protected].
  2. Department of Biology and Environmental Science, University of New Haven, West Haven, CT 06516, USA. [email protected].
  3. Australian Biologics, Sydney, NSW 2000, Australia. [email protected].
  4. Department of Biology and Environmental Science, University of New Haven, West Haven, CT 06516, USA. [email protected].
  5. School of Health Sciences, Universidad Catolica Santiago de Guayaquil, Guayaquil 090615, Ecuador. [email protected].
  6. Union Square Medical Associates, 450 Sutter Street, Suite 1504, San Francisco, CA 94108, USA. [email protected].
  7. Union Square Medical Associates, 450 Sutter Street, Suite 1504, San Francisco, CA 94108, USA. [email protected].

PMID: 29662016 PMCID: PMC6023324 DOI: 10.3390/healthcare6020033

Abstract

INTRODUCTION: Lyme disease is a tickborne illness that generates controversy among medical providers and researchers. One of the key topics of debate is the existence of persistent infection with the Lyme spirochete,

METHODS: In this pilot study, culture of body fluids and tissues was performed in a randomly selected group of 12 patients with persistent Lyme disease symptoms who had been treated or who were being treated with antibiotics. Cultures were also performed on a group of ten control subjects without Lyme disease. The cultures were subjected to corroborative microscopic, histopathological and molecular testing for

RESULTS: Motile spirochetes identified histopathologically as

CONCLUSIONS: Using multiple corroborative detection methods, we showed that patients with persistent Lyme disease symptoms may have ongoing spirochetal infection despite antibiotic treatment, similar to findings in non-human primates. The optimal treatment for persistent

Keywords: Borrelia burgdorferi; Lyme disease; chronic infection; spirochete culture; tickborne disease

Conflict of interest statement

The authors declare no conflict of interest.

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