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Stefaniak P, Kwiatkowski P, Kozielec Z, et al. Recanalization and remodeling of the great saphenous vein caused by the large melanoma's cutaneous metastasis. Contemp Oncol (Pozn). 2018;22(1):54-59doi: 10.5114/wo.2018.74396.
Stefaniak, P., Kwiatkowski, P., Kozielec, Z., & Godlewski, J. (2018). Recanalization and remodeling of the great saphenous vein caused by the large melanoma's cutaneous metastasis. Contemporary oncology (Poznan, Poland), 22(1), 54-59. https://doi.org/10.5114/wo.2018.74396
Stefaniak, Przemysław, et al. "Recanalization and remodeling of the great saphenous vein caused by the large melanoma's cutaneous metastasis." Contemporary oncology (Poznan, Poland) vol. 22,1 (2018): 54-59. doi: https://doi.org/10.5114/wo.2018.74396
Stefaniak P, Kwiatkowski P, Kozielec Z, Godlewski J. Recanalization and remodeling of the great saphenous vein caused by the large melanoma's cutaneous metastasis. Contemp Oncol (Pozn). 2018;22(1):54-59. doi: 10.5114/wo.2018.74396. Epub 2018 Apr 03. PMID: 29692666; PMCID: PMC5909732.
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Contemp Oncol (Pozn). 2018;22(1):54-59. doi: 10.5114/wo.2018.74396. Epub 2018 Apr 03.

Recanalization and remodeling of the great saphenous vein caused by the large melanoma's cutaneous metastasis.

Contemporary oncology (Poznan, Poland)

Przemysław Stefaniak, Przemysław Kwiatkowski, Zygmunt Kozielec, Janusz Godlewski

Affiliations

  1. Department of Surgical Oncology Hospital Ministry of Internal Affairs with Warmia and Mazury Oncology Centre, Olsztyn, Poland.
  2. Department of Human Histology and Embryology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Poland.
  3. Department of Pathomorphology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.

PMID: 29692666 PMCID: PMC5909732 DOI: 10.5114/wo.2018.74396

Abstract

AIM OF THE STUDY: Large melanoma tumour caused arterial remodelling of the distal part of the great saphenous vein. The metastasis occurred at the site where inguinal lymphadenectomy was previously performed and the proximal part of the great saphenous vein was resected.The aim of this study is the presentation of such a rare observation and literature overview concerning melanoma metastasis and possible stimuli causing remodelling of veins.

MATERIAL AND METHODS: Macroscopic and microscopic analyses of the large blood vessel that supplies melanoma were made. The size and structure of the blood vessel was compared with the regular great saphenous vein.

RESULTS: The macroscopic examinations allowed us to ascertain that the blood vessel that was identified intraoperatively as the great saphenous vein, has a thick, stiff wall. The microscopic analysis allowed demonstrated that the tunica media was typical for a muscular artery morphology. The morphometric analysis revealed that the blood vessel wall in the area of metastatic tumour was much thicker than the wall of a regular great saphenous vein.

CONCLUSIONS: This malignant melanoma skin metastases caused the recanalisation of the great saphenous vein the lumen of which was obliterated during the initial surgical treatment. The metastatic tumour supplied by large blood vessels grew extensively and caused arterial remodelling of the venous wall.

Keywords: great saphenous vein remodelling; melanoma malignum; melanoma metastases; muscular artery

Conflict of interest statement

The authors declare no conflict of interest.

References

  1. J Surg Oncol. 2004 Jul 1;86(4):172-8 - PubMed
  2. Science. 2005 Jan 7;307(5706):58-62 - PubMed
  3. Expert Opin Biol Ther. 2001 Jul;1(4):683-91 - PubMed
  4. J Appl Physiol (1985). 2001 Oct;91(4):1574-81 - PubMed
  5. Int J Cancer. 1999 Oct 22;84(5):494-501 - PubMed
  6. Cancers (Basel). 2010 Dec 30;3(1):126-63 - PubMed
  7. Cancer Microenviron. 2014 Dec;7(3):139-52 - PubMed
  8. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9462-7 - PubMed
  9. Dermatol Surg. 2010 Jul;36(7):1200-2 - PubMed
  10. Biochim Biophys Acta. 2004 Mar 4;1654(1):79-94 - PubMed
  11. Ann Surg. 1986 Apr;203(4):339-45 - PubMed
  12. Nat Rev Cancer. 2002 Mar;2(3):161-74 - PubMed
  13. Arterioscler Thromb Vasc Biol. 1998 Feb;18(2):227-34 - PubMed
  14. Cancers (Basel). 2010 Feb 25;2(1):114-32 - PubMed
  15. Exp Cell Res. 2010 May 1;316(8):1397-407 - PubMed
  16. J Pathol. 2001 Dec;195(5):537-42 - PubMed
  17. Histopathology. 2012 Nov;61(5):889-98 - PubMed
  18. Arch Surg. 1991 Dec;126(12):1461-8 - PubMed
  19. Nat Rev Cancer. 2003 Jun;3(6):411-21 - PubMed
  20. Br J Dermatol. 2002 Jul;147(1):62-70 - PubMed
  21. Recenti Prog Med. 2000 Nov;91(11):581-7 - PubMed

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