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J Arrhythm. 2017 Dec 14;34(1):36-45. doi: 10.1002/joa3.12010. eCollection 2018 Feb.

What factors lead to the acceleration of ventricular tachycardia during antitachycardia pacing?-Results from over 1000 episodes.

Journal of arrhythmia

Yin Fang, Kai Gu, Bing Yang, Weizhu Ju, Hongwu Chen, Mingfang Li, Hailei Liu, Jiaxian Wang, Gang Yang, Minglong Chen

Affiliations

  1. Department of Anesthesiology The First Affiliated Hospital of Nanjing Medical University Nanjing China.
  2. Department of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing China.

PMID: 29721112 PMCID: PMC5828264 DOI: 10.1002/joa3.12010

Abstract

INTRODUCTION: Ventricular tachycardia (VT) acceleration due to antitachycardia pacing (ATP) therapy could be often observed in patients with implantable cardioverter defibrillator (ICD), which usually results in additional shock. However, few studies focused on the risk factors for VT acceleration caused by ATP therapy. The purpose of this study was to investigate risk factors for VT acceleration due to ATP delivery.

METHODS: We retrospectively reviewed 1056 ATP episodes in 33 patients with structural heart diseases, of whom clinical characteristics and episodes details were evaluated.

RESULTS: At individual patient level, number of VT morphologies recorded in electrograms during follow-up was a risk factor with cutoff point of 1 (AUC 0.79, sensitivity 72.7%, specificity 77.3%,

CONCLUSIONS: Number of VT morphologies, VTCL, and mean variation in VTCL are risk factors predicting ATP acceleration. Burst stimulation with less pulse numbers should be performed in VTs with cycle length less than 347 ms.

Keywords: acceleration; antitachycardia pacing; degeneration; implantable cardioverter defibrillator; ventricular tachycardia

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