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Korevaar TIM, Tiemeier H, Peeters RP. Clinical associations of maternal thyroid function with foetal brain development: Epidemiological interpretation and overview of available evidence. Clin Endocrinol (Oxf). 2018;89(2):129-138doi: 10.1111/cen.13724.
Korevaar, T. I. M., Tiemeier, H., & Peeters, R. P. (2018). Clinical associations of maternal thyroid function with foetal brain development: Epidemiological interpretation and overview of available evidence. Clinical endocrinology, 89(2), 129-138. https://doi.org/10.1111/cen.13724
Korevaar, Tim I M, et al. "Clinical associations of maternal thyroid function with foetal brain development: Epidemiological interpretation and overview of available evidence." Clinical endocrinology vol. 89,2 (2018): 129-138. doi: https://doi.org/10.1111/cen.13724
Korevaar TIM, Tiemeier H, Peeters RP. Clinical associations of maternal thyroid function with foetal brain development: Epidemiological interpretation and overview of available evidence. Clin Endocrinol (Oxf). 2018 Aug;89(2):129-138. doi: 10.1111/cen.13724. Epub 2018 May 16. PMID: 29693263.
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Clin Endocrinol (Oxf). 2018 Aug;89(2):129-138. doi: 10.1111/cen.13724. Epub 2018 May 16.

Clinical associations of maternal thyroid function with foetal brain development: Epidemiological interpretation and overview of available evidence.

Clinical endocrinology

Tim I M Korevaar, Henning Tiemeier, Robin P Peeters

Affiliations

  1. Rotterdam Thyroid Center, Erasmus Medical Center, Rotterdam, The Netherlands.
  2. Child and Adolescent Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands.

PMID: 29693263 DOI: 10.1111/cen.13724

Abstract

Thyroid hormone is an important regulator of early brain development, particularly during early stages of gestation during which foetal thyroid hormone availability depends on the maternal transfer of thyroid hormones. There is a wide range of experimental studies showing that low maternal thyroid hormone availability is associated with suboptimal brain development parameters. While few clinical studies have shown that overt maternal hypothyroidism is associated with lower child IQ, the question whether more subclinical changes in maternal thyroid function could also lead to suboptimal foetal brain development. In this review, we put the latter studies in perspective and discuss their interpretation from an epidemiological and clinical perspective. Furthermore, we extend this discussion to also include future perspective and identify important knowledge gaps in the field.

© 2018 John Wiley & Sons Ltd.

Keywords: autism; brain; intelligence quotient; pregnancy; thyroid

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