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Rambaud J, Lidouren F, Sage M, et al. Hypothermic total liquid ventilation after experimental aspiration-associated acute respiratory distress syndrome. Ann Intensive Care. 2018;8(1):57doi: 10.1186/s13613-018-0404-8.
Rambaud, J., Lidouren, F., Sage, M., Kohlhauer, M., Nadeau, M., Fortin-Pellerin, �. �., Micheau, P., Zilberstein, L., Mongardon, N., Ricard, J. D., Terada, M., Bruneval, P., Berdeaux, A., Ghaleh, B., Walti, H., & Tissier, R. (2018). Hypothermic total liquid ventilation after experimental aspiration-associated acute respiratory distress syndrome. Annals of intensive care, 8(1), 57. https://doi.org/10.1186/s13613-018-0404-8
Rambaud, Jérôme, et al. "Hypothermic total liquid ventilation after experimental aspiration-associated acute respiratory distress syndrome." Annals of intensive care vol. 8,1 (2018): 57. doi: https://doi.org/10.1186/s13613-018-0404-8
Rambaud J, Lidouren F, Sage M, Kohlhauer M, Nadeau M, Fortin-Pellerin É, Micheau P, Zilberstein L, Mongardon N, Ricard JD, Terada M, Bruneval P, Berdeaux A, Ghaleh B, Walti H, Tissier R. Hypothermic total liquid ventilation after experimental aspiration-associated acute respiratory distress syndrome. Ann Intensive Care. 2018 May 02;8(1):57. doi: 10.1186/s13613-018-0404-8. PMID: 29721820; PMCID: PMC5931951.
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Ann Intensive Care. 2018 May 02;8(1):57. doi: 10.1186/s13613-018-0404-8.

Hypothermic total liquid ventilation after experimental aspiration-associated acute respiratory distress syndrome.

Annals of intensive care

Jérôme Rambaud, Fanny Lidouren, Michaël Sage, Matthias Kohlhauer, Mathieu Nadeau, Étienne Fortin-Pellerin, Philippe Micheau, Luca Zilberstein, Nicolas Mongardon, Jean-Damien Ricard, Megumi Terada, Patrick Bruneval, Alain Berdeaux, Bijan Ghaleh, Hervé Walti, Renaud Tissier

Affiliations

  1. U955 - IMRB, Inserm, UPEC, Ecole Nationale Vétérinaire d'Alfort, 7 avenue du Général de Gaulle, 94700, Maisons-Alfort, France.
  2. Paediatric and Neonatal Intensive Care Unit, Armand-Trousseau Hospital, UPMC, APHP, Paris, France.
  3. Université de Sherbrooke, Sherbrooke, QC, Canada.
  4. Service d'Anesthésie et des Réanimations Chirurgicales, DHU A-TVB, Hôpitaux Universitaires Henri Mondor, Assistance Publique des Hôpitaux de Paris, Créteil, France.
  5. UMR 1137, Inserm, Université Paris Diderot, Hôpital Louis Mourier, Réanimation Médico-chirurgicale, APHP, Colombes, France.
  6. UMR 970, Inserm, Paris Cardiovascular Research Center, Hôpital Européen Georges Pompidou, Paris, France.
  7. U955 - IMRB, Inserm, UPEC, Ecole Nationale Vétérinaire d'Alfort, 7 avenue du Général de Gaulle, 94700, Maisons-Alfort, France. [email protected].

PMID: 29721820 PMCID: PMC5931951 DOI: 10.1186/s13613-018-0404-8

Abstract

BACKGROUND: Ultrafast cooling by total liquid ventilation (TLV) provides potent cardio- and neuroprotection after experimental cardiac arrest. However, this was evaluated in animals with no initial lung injury, whereas out-of-hospital cardiac arrest is frequently associated with early-onset pneumonia, which may lead to acute respiratory distress syndrome (ARDS). Here, our objective was to determine whether hypothermic TLV could be safe or even beneficial in an aspiration-associated ARDS animal model.

METHODS: ARDS was induced in anesthetized rabbits through a two-hits model including the intra-tracheal administration of a pH = 1 solution mimicking gastric content and subsequent gaseous non-protective ventilation during 90 min (tidal volume [Vt] = 10 ml/kg with positive end-expiration pressure [PEEP] = 0 cmH

RESULTS: Eight rabbits were included in each group. Before randomization, all animals elicited ARDS with arterial oxygen partial pressure over inhaled oxygen fraction ratios (PaO

CONCLUSION: Hypothermic TLV can be safely induced in rabbits during aspiration-associated ARDS. It modified neither gas exchanges nor respiratory mechanics but reduced lung inflammation and hemodynamic failure in comparison with LPV. Since hypothermic TLV was previously shown to provide neuro- and cardio protective effects after cardiac arrest, these findings suggest a possible use of TLV in the settings of cardiac arrest-associated ARDS.

Keywords: ARDS; Aspiration; Cardiac arrest; Hypothermia; Pneumonia; Total liquid ventilation

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