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van Poppel MN, Eder M, Lang U, et al. Sex-specific associations of insulin-like peptides in cord blood with size at birth. Clin Endocrinol (Oxf). 2018;89(2):187-193doi: 10.1111/cen.13739.
van Poppel, M. N., Eder, M., Lang, U., & Desoye, G. (2018). Sex-specific associations of insulin-like peptides in cord blood with size at birth. Clinical endocrinology, 89(2), 187-193. https://doi.org/10.1111/cen.13739
van Poppel, Mireille Nm, et al. "Sex-specific associations of insulin-like peptides in cord blood with size at birth." Clinical endocrinology vol. 89,2 (2018): 187-193. doi: https://doi.org/10.1111/cen.13739
van Poppel MN, Eder M, Lang U, Desoye G. Sex-specific associations of insulin-like peptides in cord blood with size at birth. Clin Endocrinol (Oxf). 2018 Aug;89(2):187-193. doi: 10.1111/cen.13739. Epub 2018 May 29. PMID: 29751363.
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Clin Endocrinol (Oxf). 2018 Aug;89(2):187-193. doi: 10.1111/cen.13739. Epub 2018 May 29.

Sex-specific associations of insulin-like peptides in cord blood with size at birth.

Clinical endocrinology

Mireille Nm van Poppel, Martina Eder, Uwe Lang, Gernot Desoye

Affiliations

  1. Institute of Sport Science, University of Graz, Graz, Austria.
  2. Department of Public and Occupational Health, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.
  3. Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria.

PMID: 29751363 DOI: 10.1111/cen.13739

Abstract

OBJECTIVE: Insulin-like peptides (insulin, IGF-1, IGF-2) are essential regulators of foetal growth. We assessed the role of these peptides for birth size in a sex-specific manner.

DESIGN: Cross-sectional cohort analysis.

PATIENTS AND MEASUREMENTS: In 369 neonates, cord blood insulin, C-peptide, IGF-1 and IGF-2 levels were measured. Outcomes were placenta weight, birthweight, length and ponderal index. In linear regression models, the association of insulin-like peptides with growth outcomes was assessed, adjusted for gestational age and delivery mode. Interaction between insulin-like peptides and neonatal sex was assessed.

RESULTS: No sex differences in levels of insulin-like peptides were observed. Significant interactions were found of sex with IGF-1 for birthweight, and of sex with C-peptide for all outcomes, except ponderal index. The association of IGF-1 (ng/mL) with birthweight was stronger and only significant in males (beta coefficient 3.30 g; 95%CI 1.98-4.63 in males and 1.45 g; -0.09-2.99 in females). Associations of C-peptide (ng/mL) with growth outcomes were stronger and only significant in females (placenta weight females: 181.3 g; 109.3-253.3; P < .001, males: 29.8 g; -51.5-111.1; P = .47, birthweight females: 598.5 g; 358.3-838.7: P < .001, males: 113.7 g; -154.0-381.4; P = .40). Associations of IGF2 with birthweight were similar in males and females. No associations were found with ponderal index.

CONCLUSIONS: C-peptide and IGF-1 in cord blood associate with birthweight, length and placenta weight in a sex-specific manner, with stronger associations of C-peptide levels with placenta weight, birthweight and length in females and stronger associations of IGF-1 levels with birthweight in males.

© 2018 John Wiley & Sons Ltd.

Keywords: IGF ; birth length; birthweight; cord blood; insulin; neonatal growth; placenta weight

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