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Roy DG, Kaur U, Chawla YK, et al. Effect of isosorbide dinitrate on non-cirrhotic portal hypertension. Natl Med J India. 1991;4(1):5-9
Roy, D. G., Kaur, U., Chawla, Y. K., Singh, K., & Dilawari, J. B. (1991). Effect of isosorbide dinitrate on non-cirrhotic portal hypertension. The National medical journal of India, 4(1), 5-9.
Roy, D Ghosh, et al. "Effect of isosorbide dinitrate on non-cirrhotic portal hypertension." The National medical journal of India vol. 4,1 (1991): 5-9.
Roy DG, Kaur U, Chawla YK, Singh K, Dilawari JB. Effect of isosorbide dinitrate on non-cirrhotic portal hypertension. Natl Med J India. 1991 Jan-Feb;4(1):5-9. PMID: 29751471.
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Natl Med J India. 1991 Jan-Feb;4(1):5-9.

Effect of isosorbide dinitrate on non-cirrhotic portal hypertension.

The National medical journal of India

D Ghosh Roy, U Kaur, Y K Chawla, K Singh, J B Dilawari

Affiliations

  1. Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
  2. Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
  3. Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

PMID: 29751471

Abstract

Among the many drugs including propranolol that have been evaluated for the pharmacological control of portal hypertension, isosorbide dinitrate (ISDN) fulfils the criteria of patient acceptability, ease of administration and production of the desired effect. Forty-three consecutive patients with uncomplicated noncirrhotic portal hypertension (NCPH) caused by extrahepatic portal venous obstruction (EHO=32) and non-cirrhotic portal fibrosis (NCPF=l1) were given 20 mg of ISDN sublingually and in the supine position the intrasplenic pulp pressure (ISPP) was monitored for 10 minutes. The fall in mean ISPP became significant at 4 minutes in patients with EHO (p

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