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Oakley P, Kisely S, Baxter A, et al. Increased mortality among people with schizophrenia and other non-affective psychotic disorders in the community: A systematic review and meta-analysis. J Psychiatr Res. 2018;102:245-253doi: 10.1016/j.jpsychires.2018.04.019.
Oakley, P., Kisely, S., Baxter, A., Harris, M., Desoe, J., Dziouba, A., & Siskind, D. (2018). Increased mortality among people with schizophrenia and other non-affective psychotic disorders in the community: A systematic review and meta-analysis. Journal of psychiatric research, 102245-253. https://doi.org/10.1016/j.jpsychires.2018.04.019
Oakley, Padraig, et al. "Increased mortality among people with schizophrenia and other non-affective psychotic disorders in the community: A systematic review and meta-analysis." Journal of psychiatric research vol. 102 (2018): 245-253. doi: https://doi.org/10.1016/j.jpsychires.2018.04.019
Oakley P, Kisely S, Baxter A, Harris M, Desoe J, Dziouba A, Siskind D. Increased mortality among people with schizophrenia and other non-affective psychotic disorders in the community: A systematic review and meta-analysis. J Psychiatr Res. 2018 Jul;102:245-253. doi: 10.1016/j.jpsychires.2018.04.019. Epub 2018 Apr 26. PMID: 29723811.
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J Psychiatr Res. 2018 Jul;102:245-253. doi: 10.1016/j.jpsychires.2018.04.019. Epub 2018 Apr 26.

Increased mortality among people with schizophrenia and other non-affective psychotic disorders in the community: A systematic review and meta-analysis.

Journal of psychiatric research

Padraig Oakley, Steve Kisely, Amanda Baxter, Meredith Harris, Jocelyne Desoe, Alyona Dziouba, Dan Siskind

Affiliations

  1. Queensland Centre for Mental Health Research, Brisbane, Australia.
  2. Metro South Addiction and Mental Health Service, Brisbane, Australia; University of Queensland School of Medicine, Brisbane, Australia; Departments of Psychiatry, Community Health and Epidemiology, Dalhousie University, Canada.
  3. Queensland Centre for Mental Health Research, Brisbane, Australia; School of Public Health, The University of Queensland, Brisbane, Australia.
  4. University of Queensland School of Medicine, Brisbane, Australia.
  5. Queensland Centre for Mental Health Research, Brisbane, Australia; Metro South Addiction and Mental Health Service, Brisbane, Australia; University of Queensland School of Medicine, Brisbane, Australia. Electronic address: [email protected].

PMID: 29723811 DOI: 10.1016/j.jpsychires.2018.04.019

Abstract

INTRODUCTION: There is increasing evidence of excess mortality in schizophrenia but less information on other non-affective psychoses. We therefore generated standardised mortality ratios (SMRs) for community-dwelling people with schizophrenia and other non-affective psychoses, relative to the general population, and examined changes to the SMR over time.

METHODS: We conducted a systematic review in which Pubmed, CINAHL, EMBASE, Google Scholar and PsycINFO were searched for publications that reported SMRs for all-cause mortality among community-dwelling people with schizophrenia and psychotic disorders. Meta-analyses of SMRs were conducted, pooled across genders and then separately by gender. Sub-group analyses were conducted for diagnostic group, global region, decade and risk of study bias.

RESULTS: We were able to include 34 studies covering 1,724,906 participants. The gender pooled SMR for schizophrenia and psychotic disorders was 3.08 (95%CI 2.88-3.31). Schizophrenia and broader psychotic disorders had similar SMRs. Stratification by decade of observation suggests that the difference in SMR is not declining and may possibly be widening. Analyses showed high levels of heterogeneity.

CONCLUSIONS: The appearance of a static or widening mortality gap over time between people with schizophrenia and psychotic disorders and the general population is of concern. However, whether it is an increase over time is unclear, as there are insufficient studies to confirm this.

Copyright © 2018 Elsevier Ltd. All rights reserved.

Keywords: Mortality; Non-affective psychoses; Schizophrenia

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