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de Mattos-Shipley KMJ, Greco C, Heard DM, et al. The cycloaspeptides: uncovering a new model for methylated nonribosomal peptide biosynthesis. Chem Sci. 2018;9(17):4109-4117doi: 10.1039/c8sc00717a.
de Mattos-Shipley, K. M. J., Greco, C., Heard, D. M., Hough, G., Mulholland, N. P., Vincent, J. L., Micklefield, J., Simpson, T. J., Willis, C. L., Cox, R. J., & Bailey, A. M. (2018). The cycloaspeptides: uncovering a new model for methylated nonribosomal peptide biosynthesis. Chemical science, 9(17), 4109-4117. https://doi.org/10.1039/c8sc00717a
de Mattos-Shipley, Kate M J, et al. "The cycloaspeptides: uncovering a new model for methylated nonribosomal peptide biosynthesis." Chemical science vol. 9,17 (2018): 4109-4117. doi: https://doi.org/10.1039/c8sc00717a
de Mattos-Shipley KMJ, Greco C, Heard DM, Hough G, Mulholland NP, Vincent JL, Micklefield J, Simpson TJ, Willis CL, Cox RJ, Bailey AM. The cycloaspeptides: uncovering a new model for methylated nonribosomal peptide biosynthesis. Chem Sci. 2018 Apr 10;9(17):4109-4117. doi: 10.1039/c8sc00717a. eCollection 2018 May 07. PMID: 29780540; PMCID: PMC5941284.
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Chem Sci. 2018 Apr 10;9(17):4109-4117. doi: 10.1039/c8sc00717a. eCollection 2018 May 07.

The cycloaspeptides: uncovering a new model for methylated nonribosomal peptide biosynthesis.

Chemical science

Kate M J de Mattos-Shipley, Claudio Greco, David M Heard, Gemma Hough, Nicholas P Mulholland, Jason L Vincent, Jason Micklefield, Thomas J Simpson, Christine L Willis, Russell J Cox, Andrew M Bailey

Affiliations

  1. School of Chemistry , University of Bristol , Cantock's Close , Bristol , BS8 1TS , UK . Email: [email protected].
  2. Syngenta Ltd. , Jealott's Hill International Research Centre Bracknell , Berkshire , RG42 6EY , UK.
  3. School of Chemistry , University of Manchester , Oxford Road , Manchester , M1 7DN , UK.
  4. Institute für Organsche Chemie , Leibniz Universität Hannover , Schneiderberg 1A , 30167 Hannover , Germany.
  5. BMWZ , Leibniz Universität Hannover , Schneiderberg 38 , 30167 Hannover , Germany.
  6. School of Biological Sciences , University of Bristol , Life Sciences Building, 24 Tyndall Avenue , Bristol , BS8 1TQ , UK . Email: [email protected].

PMID: 29780540 PMCID: PMC5941284 DOI: 10.1039/c8sc00717a

Abstract

The cycloaspeptides are bioactive pentapeptides produced by various filamentous fungi, which have garnered interest from the agricultural industry due to the reported insecticidal activity of the minor metabolite, cycloaspeptide E. Genome sequencing, bioinformatics and heterologous expression confirmed that the cycloaspeptide gene cluster contains a minimal 5-module nonribosomal peptide synthetase (NRPS) and a new type of

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