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Lawrence BJ, Gasson N, Johnson AR, et al. Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson's Disease: A Randomized Controlled Trial. Parkinsons Dis. 2018;2018:4318475doi: 10.1155/2018/4318475.
Lawrence, B. J., Gasson, N., Johnson, A. R., Booth, L., & Loftus, A. M. (2018). Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson's Disease: A Randomized Controlled Trial. Parkinson's disease, 20184318475. https://doi.org/10.1155/2018/4318475
Lawrence, Blake J, et al. "Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson's Disease: A Randomized Controlled Trial." Parkinson's disease vol. 2018 (2018): 4318475. doi: https://doi.org/10.1155/2018/4318475
Lawrence BJ, Gasson N, Johnson AR, Booth L, Loftus AM. Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson's Disease: A Randomized Controlled Trial. Parkinsons Dis. 2018 Mar 26;2018:4318475. doi: 10.1155/2018/4318475. eCollection 2018. PMID: 29780572; PMCID: PMC5892209.
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Parkinsons Dis. 2018 Mar 26;2018:4318475. doi: 10.1155/2018/4318475. eCollection 2018.

Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson's Disease: A Randomized Controlled Trial.

Parkinson's disease

Blake J Lawrence, Natalie Gasson, Andrew R Johnson, Leon Booth, Andrea M Loftus

Affiliations

  1. Curtin Neuroscience Laboratory, School of Psychology and Speech Pathology, Curtin University, Bentley, WA 6102, Australia.
  2. ParkC Collaborative Research Group, Curtin University, Bentley, WA 6102, Australia.
  3. Ear Science Institute Australia, Subiaco, WA, Australia.
  4. Ear Sciences Centre, School of Surgery, The University of Western Australia, Crawley, WA, Australia.

PMID: 29780572 PMCID: PMC5892209 DOI: 10.1155/2018/4318475

Abstract

This study examined whether standard cognitive training, tailored cognitive training, transcranial direct current stimulation (tDCS), standard cognitive training + tDCS, or tailored cognitive training + tDCS improved cognitive function and functional outcomes in participants with PD and mild cognitive impairment (PD-MCI). Forty-two participants with PD-MCI were randomized to one of six groups: (1) standard cognitive training, (2) tailored cognitive training, (3) tDCS, (4) standard cognitive training + tDCS, (5) tailored cognitive training + tDCS, or (6) a control group. Interventions lasted 4 weeks, with cognitive and functional outcomes measured at baseline, post-intervention, and follow-up. The trial was registered with the Australian New Zealand Clinical Trials Registry (ANZCTR: 12614001039673). While controlling for moderator variables, Generalized Linear Mixed Models (GLMMs) showed that when compared to the control group, the intervention groups demonstrated variable statistically significant improvements across executive function, attention/working memory, memory, language, activities of daily living (ADL), and quality of life (QOL; Hedge's

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