Display options
Cite
Di Rita A, D'Acunzo P, Simula L, et al. AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells. Front Cell Neurosci. 2018;12:92doi: 10.3389/fncel.2018.00092.
Di Rita, A., D'Acunzo, P., Simula, L., Campello, S., Strappazzon, F., & Cecconi, F. (2018). AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells. Frontiers in cellular neuroscience, 1292. https://doi.org/10.3389/fncel.2018.00092
Di Rita, Anthea, et al. "AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells." Frontiers in cellular neuroscience vol. 12 (2018): 92. doi: https://doi.org/10.3389/fncel.2018.00092
Di Rita A, D'Acunzo P, Simula L, Campello S, Strappazzon F, Cecconi F. AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells. Front Cell Neurosci. 2018 Apr 18;12:92. doi: 10.3389/fncel.2018.00092. eCollection 2018. PMID: 29755319; PMCID: PMC5932353.
Copy Download .nbib Format: NLM
Share it on

Front Cell Neurosci. 2018 Apr 18;12:92. doi: 10.3389/fncel.2018.00092. eCollection 2018.

AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells.

Frontiers in cellular neuroscience

Anthea Di Rita, Pasquale D'Acunzo, Luca Simula, Silvia Campello, Flavie Strappazzon, Francesco Cecconi

Affiliations

  1. IRCCS Fondazione Santa Lucia, Rome, Italy.
  2. Department of Biology, University of Rome Tor Vergata, Rome, Italy.
  3. Department of Paediatric Haematology and Oncology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
  4. Unit of Cell Stress and Survival, Danish Cancer Society Research Center, Copenhagen, Denmark.

PMID: 29755319 PMCID: PMC5932353 DOI: 10.3389/fncel.2018.00092

Abstract

Therapeutic strategies are needed to protect dopaminergic neurons in Parkinson's disease (PD) patients. Oxidative stress caused by dopamine may play an important role in PD pathogenesis. Selective autophagy of mitochondria (mitophagy), mainly regulated by PINK1 and PARKIN, plays an important role in the maintenance of cell homeostasis. Mutations in those genes cause accumulation of damaged mitochondria, leading to nigral degeneration and early-onset PD. AMBRA1

Keywords: Parkinson’s disease; cell death; in vitro models; mitophagy; oxidative stress

References

  1. J Microsc. 2006 Dec;224(Pt 3):213-32 - PubMed
  2. J Exp Med. 1991 Oct 1;174(4):881-9 - PubMed
  3. J Biol Chem. 2007 Aug 17;282(33):24131-45 - PubMed
  4. Nat Neurosci. 2000 Dec;3(12):1301-6 - PubMed
  5. J Biol Chem. 2006 Mar 3;281(9):5373-82 - PubMed
  6. Nature. 2006 Oct 19;443(7113):787-95 - PubMed
  7. Nature. 2016 Apr 14;532(7598):255-8 - PubMed
  8. J Neurosci. 2011 Jul 13;31(28):10249-61 - PubMed
  9. Sci Rep. 2017 Mar 10;7:44373 - PubMed
  10. EMBO J. 2000 Nov 1;19(21):5720-8 - PubMed
  11. Nature. 2015 Aug 20;524(7565):309-314 - PubMed
  12. EMBO J. 2011 Apr 6;30(7):1195-208 - PubMed
  13. J Cell Biol. 2010 May 17;189(4):671-9 - PubMed
  14. FEBS Lett. 1997 Oct 13;416(1):15-8 - PubMed
  15. J Neural Transm Suppl. 1997;50:55-66 - PubMed
  16. Nature. 2008 Jul 10;454(7201):232-5 - PubMed
  17. Mol Cell Biochem. 2013 Dec;384(1-2):59-69 - PubMed
  18. Biochem Biophys Res Commun. 1993 Feb 15;190(3):1090-6 - PubMed
  19. Exp Neurol. 1996 Sep;141(1):32-9 - PubMed
  20. Rejuvenation Res. 2005 Spring;8(1):3-5 - PubMed
  21. Neuropharmacology. 2001 Jun;40(8):959-75 - PubMed
  22. Nat Biotechnol. 2002 Jan;20(1):87-90 - PubMed
  23. J Bioenerg Biomembr. 2000 Apr;32(2):153-62 - PubMed
  24. Neurobiol Dis. 2014 Oct;70:214-23 - PubMed
  25. J Mol Neurosci. 2002 Jun;18(3):229-38 - PubMed
  26. Front Cell Neurosci. 2015 Apr 10;9:124 - PubMed
  27. Cell Death Differ. 2015 Mar;22(3):419-32 - PubMed
  28. Neurosci Lett. 2003 May 1;341(2):87-90 - PubMed
  29. Autophagy. 2016 Jun 2;12 (6):963-75 - PubMed
  30. J Biol Chem. 2003 Mar 7;278(10):8516-25 - PubMed

Publication Types