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McCarty CA, Peissig P, Caldwell MD, et al. The Marshfield Clinic Personalized Medicine Research Project: 2008 scientific update and lessons learned in the first 6 years. Per Med. 2008;5(5):529-542doi: 10.2217/17410541.5.5.529.
McCarty, C. A., Peissig, P., Caldwell, M. D., & Wilke, R. A. (2008). The Marshfield Clinic Personalized Medicine Research Project: 2008 scientific update and lessons learned in the first 6 years. Personalized medicine, 5(5), 529-542. https://doi.org/10.2217/17410541.5.5.529
McCarty, Catherine A, et al. "The Marshfield Clinic Personalized Medicine Research Project: 2008 scientific update and lessons learned in the first 6 years." Personalized medicine vol. 5,5 (2008): 529-542. doi: https://doi.org/10.2217/17410541.5.5.529
McCarty CA, Peissig P, Caldwell MD, Wilke RA. The Marshfield Clinic Personalized Medicine Research Project: 2008 scientific update and lessons learned in the first 6 years. Per Med. 2008 Sep;5(5):529-542. doi: 10.2217/17410541.5.5.529. PMID: 29783440.
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Per Med. 2008 Sep;5(5):529-542. doi: 10.2217/17410541.5.5.529.

The Marshfield Clinic Personalized Medicine Research Project: 2008 scientific update and lessons learned in the first 6 years.

Personalized medicine

Catherine A McCarty, Peggy Peissig, Michael D Caldwell, Russell A Wilke

Affiliations

  1. Center for Human Genetics, Marshfield Clinic Research Foundation, 1000 N Oak Avenue (ML1), Marshfield, WI 54449, USA. [email protected].
  2. Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, 1000 N Oak Avenue (ML1), Marshfield, WI 54449, USA.
  3. Department of Surgery, Marshfield Clinic, 1000 N Oak Avenue (ML1), Marshfield, WI 54449, USA.
  4. Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee,WI, USA.
  5. Department of Pharmacology and Toxicology, Medical College of Wisconsin, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee,WI, USA.
  6. Human and Molecular Genetics Center, Medical College of Wisconsin, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee,WI, USA.

PMID: 29783440 DOI: 10.2217/17410541.5.5.529

Abstract

The Marshfield Clinic Personalized Medicine Research Project is the largest population-based biobank in the USA, with the ability to recontact subjects to obtain additional information to facilitate gene-environment studies. Nearly 20,000 adults have enrolled in the Personalized Medicine Research Project since 2001, after providing active written consent to access their Marshfield Clinic medical records to define phenotype and providing blood samples from which DNA, plasma and serum samples were stored. Numerous studies are underway in the area of pharmacogenetics and genetic epidemiology. In addition to the scientific discoveries being made, much has been learned regarding biobanking and the management of large amounts of data being generated. The purpose of this paper is to share the advice provided by the external Scientific Advisory Board and the scientific lessons learned along the way to build this research infrastructure and facilitate its use.

Keywords: biobank; genetic epidemiology; methods; pharmacogenetics

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