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Fazeli SA, Abbasi M, Jalali H, et al. Bullous Fixed Drug Eruption Following Ibuprofen Ingestion. J Res Pharm Pract. 2018;7(1):51-56doi: 10.4103/jrpp.JRPP_17_81.
Fazeli, S. A., Abbasi, M., Jalali, H., Eskandari, S., Shamshirgaran, F., Dehghani, Z., Golabchifard, R., Ghiyasvand, S., & Ghannad, K. (2018). Bullous Fixed Drug Eruption Following Ibuprofen Ingestion. Journal of research in pharmacy practice, 7(1), 51-56. https://doi.org/10.4103/jrpp.JRPP_17_81
Fazeli, Seyed Amirhossein, et al. "Bullous Fixed Drug Eruption Following Ibuprofen Ingestion." Journal of research in pharmacy practice vol. 7,1 (2018): 51-56. doi: https://doi.org/10.4103/jrpp.JRPP_17_81
Fazeli SA, Abbasi M, Jalali H, Eskandari S, Shamshirgaran F, Dehghani Z, Golabchifard R, Ghiyasvand S, Ghannad K. Bullous Fixed Drug Eruption Following Ibuprofen Ingestion. J Res Pharm Pract. 2018 Jan-Mar;7(1):51-56. doi: 10.4103/jrpp.JRPP_17_81. PMID: 29756000; PMCID: PMC5934989.
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J Res Pharm Pract. 2018 Jan-Mar;7(1):51-56. doi: 10.4103/jrpp.JRPP_17_81.

Bullous Fixed Drug Eruption Following Ibuprofen Ingestion.

Journal of research in pharmacy practice

Seyed Amirhossein Fazeli, Morteza Abbasi, Hadi Jalali, Sonia Eskandari, Farzaneh Shamshirgaran, Zahra Dehghani, Reza Golabchifard, Shahram Ghiyasvand, Kaveh Ghannad

Affiliations

  1. Department of Anatomy, Gorgan University of Medical Sciences, Gorgan, Iran.
  2. Department of Embryology and Histology, Gorgan University of Medical Sciences, Gorgan, Iran.
  3. Department of Internal Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
  4. Department of Nursing, Birjand University of Medical Sciences, Birjand, Iran.
  5. Department of Emergency, Sarbisheh Ali-Ebne-Abitaleb Hospital, Birjand University of Medical Sciences, Birjand, Iran.
  6. Department of Pathology, Birjand University of Medical Sciences, Birjand, Iran.
  7. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  8. Department of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.
  9. Department of Radiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  10. Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  11. Department of Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

PMID: 29756000 PMCID: PMC5934989 DOI: 10.4103/jrpp.JRPP_17_81

Abstract

Fixed drug eruption (FDE) is a drug reaction involving skin and less commonly mucosal membranes. The common manifestation is localized well-demarcated patches or plaques appeared following receiving of a culprit drug. When re-exposure occurs, the rashes will appear at areas involved in previous episodes. Limited reports on bullous FDE due to ibuprofen have been documented before. Herein, we described an elderly man who experienced multifocal lesions in his oral mucosa, penis, and multiple sites of skin following ibuprofen ingestion confirmed as FDE by pathological studies. The culprit drug had been discontinued. Systemic and topical glucocorticoids as well as supportive care had been instituted. The patient's outcome was favorable and his lesions had been recovered within the next weeks. Patient's follow-up showed that he had received ibuprofen again sometime later resulting in anal mucosal lesion and similar penile involvement. In routine clinical practice, mucocutaneous adverse drug reactions should be considered. A high index of suspicion, the detailed medication history, the course of the symptoms, and distributing pattern of the lesions are essential clues for the diagnosis. However, judicious and prompt pathological studies can help to differentiate multifocal bullous FDE from major skin drug reactions such as Stevens-Johnson syndrome/toxic epidermal necrolysis.

Keywords: Bullous; Ibuprofen; Stevens–Johnson syndrome; fixed drug eruption; toxic epidermal necrolysis

Conflict of interest statement

There are no conflicts of interest.

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