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Imaoka A, Abiru K, Akiyoshi T, et al. Food intake attenuates the drug interaction between new quinolones and aluminum. J Pharm Health Care Sci. 2018;4:11doi: 10.1186/s40780-018-0107-1.
Imaoka, A., Abiru, K., Akiyoshi, T., & Ohtani, H. (2018). Food intake attenuates the drug interaction between new quinolones and aluminum. Journal of pharmaceutical health care and sciences, 411. https://doi.org/10.1186/s40780-018-0107-1
Imaoka, Ayuko, et al. "Food intake attenuates the drug interaction between new quinolones and aluminum." Journal of pharmaceutical health care and sciences vol. 4 (2018): 11. doi: https://doi.org/10.1186/s40780-018-0107-1
Imaoka A, Abiru K, Akiyoshi T, Ohtani H. Food intake attenuates the drug interaction between new quinolones and aluminum. J Pharm Health Care Sci. 2018 May 14;4:11. doi: 10.1186/s40780-018-0107-1. eCollection 2018. PMID: 29785276; PMCID: PMC5950139.
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J Pharm Health Care Sci. 2018 May 14;4:11. doi: 10.1186/s40780-018-0107-1. eCollection 2018.

Food intake attenuates the drug interaction between new quinolones and aluminum.

Journal of pharmaceutical health care and sciences

Ayuko Imaoka, Kosuke Abiru, Takeshi Akiyoshi, Hisakazu Ohtani

Affiliations

  1. Division of Clinical Pharmacokinetics, Keio University Faculty of Pharmacy, 1-5-30, Shibakoen Minato-ku, Tokyo, 105-8512 Japan.

PMID: 29785276 PMCID: PMC5950139 DOI: 10.1186/s40780-018-0107-1

Abstract

BACKGROUND: Intestinal absorption of new quinolones is decreased by oral administration of polyvalent metal cations. Some clinical studies have demonstrated this drug - drug interaction is more prominent under fasted condition. However, the effect of food intake on the extent of drug - drug interaction between new quinolones and metal cations remains to be investigated quantitatively and systematically. The aim of this study was to develop an animal model that enables to evaluate the effect of food intake on the extent of drug - drug interaction in the gastrointestinal tract by chelation and to apply the model to evaluate quantitatively the effect of food intake on the drug - drug interaction between two new quinolones, ofloxacin or ciprofloxacin and sucralfate.

METHODS: The rats were orally administered new quinolones (5.3 mg/kg of ofloxacin or 10 mg/kg of ciprofloxacin) with or without 13.3 mg/kg of sucralfate under fasted or fed condition and plasma concentration profiles of new quinolones were monitored. To the fed group, standard breakfast used in human studies was pasted and administered at a dose of 8.8 g/kg.

RESULTS: The area under the plasma concentration - time curves (AUC

CONCLUSIONS: The developed animal model quantitatively reproduced the effect of food intake on the drug - drug interaction between ofloxacin and sucralfate. The similar influences were observed for the drug - drug interaction between ciprofloxacin and sucralfate, suggesting that the extent of drug - drug interaction caused by chelation is generally attenuated by food intake.

Keywords: Absorption; Aluminum; Chelation; Ciprofloxacin; Drug - drug interaction; Food; New quinolones; Ofloxacin

Conflict of interest statement

All animal experiments received approval from the Institutional Review Board and Animal Research Committee of the Keio University Faculty of Pharmacy. All experiments adhered to the university “Regula

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